AB193338

Anti-Ornithine Decarboxylase/ODC antibody [ODC1/485]

Name: Anti-Ornithine Decarboxylase/ODC antibody [ODC1/485] (ab193338) | Abcam
Brand: Abcam Limited
SKU: AB193338

Be the first to review this product! Submit a review

(5 Publications)

Mouse Monoclonal Ornithine Decarboxylase/ODC antibody. Suitable for IHC-P, ICC/IF, WB and reacts with Rat, Mouse, Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ODC1.

View Alternative Names

Ornithine decarboxylase, ODC, ODC1

6 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ornithine Decarboxylase/ODC antibody [ODC1/485] (AB193338)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ornithine Decarboxylase/ODC antibody [ODC1/485] (AB193338)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human prostate carcinoma tissue section labeling Ornithine Decarboxylase / ODC with ab193338 at 1 µg/mL.

Immunocytochemistry/ Immunofluorescence - Anti-Ornithine Decarboxylase/ODC antibody [ODC1/485] (AB193338)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Ornithine Decarboxylase/ODC antibody [ODC1/485] (AB193338)

Immunocytochemistry analysis of LNCaP cells labelling Ornithine Decarboxylase/ODC with ab193338 at 2 µg/mL. Nuclear DNA was labelled with DAPI (blue).

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ornithine Decarboxylase/ODC antibody [ODC1/485] (AB193338)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human testicular carcinoma tissue section labeling Ornithine Decarboxylase / ODC with ab212690 at 1 μg/mL.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ornithine Decarboxylase/ODC antibody [ODC1/485] (AB193338)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Rat pancreas tissue section labeling Ornithine Decarboxylase / ODC with ab193338 at 1 µg/mL.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ornithine Decarboxylase/ODC antibody [ODC1/485] (AB193338)

Immunohistochemical analysis of formalin fixed paraffin embedded mouse pancreas labeling Ornithine Decarboxylase/ODC with ab193338 at 0.5 μg/ml.

Supplier Data

Western blot - Anti-Ornithine Decarboxylase/ODC antibody [ODC1/485] (AB193338)

All lanes:

Western blot - Anti-Ornithine Decarboxylase/ODC antibody [ODC1/485] (ab193338) at 1 µg/mL

All lanes:

Human placenta tissue lysate

Predicted band size: 51 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

ODC1/485

Isotype

IgG1

Light chain type

kappa

Carrier free

Reacts with

Mouse, Rat, Human

Applications

WB, IHC-P, ICC/IF

applications

Immunogen

Recombinant Full Length Protein corresponding to Human ODC1.

P11926

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "0.5-1 µg/mL", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1-2 µg/mL", "ICCIF-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-1 µg/mL", "WB-species-notes": "" }, "Mouse": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "0.5-1 µg/mL", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "0.5-1 µg/mL", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Chinese hamster": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

style

left-column

style

left-column

Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

style

left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Ornithine Decarboxylase also known as ODC or ODC1 is an enzyme that plays an important role in polyamine biosynthesis. This enzyme catalyzes the decarboxylation of ornithine to form putrescine a precursor for spermidine and spermine. ODC is a small protein with a molecular mass around 48 kDa. It is expressed in various tissues including the liver kidney and brain. ODC expression tends to be highest in rapidly growing tissues due to its involvement in cell growth and differentiation.

Biological function summary

ODC actively participates in cell proliferation and differentiation by regulating the levels of polyamines which are essential for DNA stabilization and cellular processes. While ODC does not form part of a larger protein complex its activity requires the presence of cofactor pyridoxal 5'-phosphate. By controlling polyamine synthesis ODC influences gene expression ion channel functions and protein synthesis impacting cell cycle progression and apoptosis.

Pathways

Ornithine decarboxylation connects with important biological processes such as the urea cycle and polyamine biosynthetic pathway. In these pathways enzymes like arginase and S-adenosylmethionine decarboxylase work closely with ODC. ODC's role in regulating polyamine levels makes it an important component of cellular metabolism and growth pathways. Through these pathways ODC coordinates with other proteins to ensure proper cellular function and response to growth signals.

ODC activity has been linked to cancer and neurological disorders. Overexpression and dysregulation of ODC can lead to increased polyamine levels which associate with tumor development and proliferation particularly in colorectal cancer. ODC also connects with proteins like c-Myc which regulates its expression and is often dysregulated in cancer. In neurological disorders abnormal ODC function affects neurodegeneration influencing proteins involved in neuronal survival and plasticity.

style

left-column

style

left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

Target data

Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.

See full target information ODC1

style

left-column

Publications (5)

Recent publications for all applications. Explore the full list and refine your search

NPJ Parkinson's disease 11:237 PubMed40790122

2025

Urea cycle dysregulation drives metabolic stress and neurodegeneration in Parkinson's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Shengyao Zhang,Guoran Wan,Yu Qiu,Meng Zhang,Hongmei Deng,Qiongfang Wang,Junyi Hu,Jie Gui,Dilong Chen,Boyue Huang,Jianhua Ran

Journal of the National Cancer Center 5:57-74 PubMed40040873

2025

Overexpression of ornithine decarboxylase 1 mediates the immune-deserted microenvironment and poor prognosis in diffuse large B-cell lymphoma.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaojie Liang,Jia Guo,Xiaofang Wang,Baiwei Luo,Ruiying Fu,Haiying Chen,Yunong Yang,Zhihao Jin,Chaoran Lin,Aimin Zang,Youchao Jia,Lin Feng,Liang Wang

Nucleic acids research 50:2872-2888 PubMed35150276

2022

Genome-wide RNAi screen identifies novel players in human 60S subunit biogenesis including key enzymes of polyamine metabolism.

Applications

Unspecified application

Species

Unspecified reactive species

Kerstin Dörner,Lukas Badertscher,Bianka Horváth,Réka Hollandi,Csaba Molnár,Tobias Fuhrer,Roger Meier,Marie Sárazová,Jasmin van den Heuvel,Nicola Zamboni,Peter Horvath,Ulrike Kutay

Journal of the American Society of Nephrology : JA 29:2310-2325 PubMed30042193

2018

Interactions between Macrophages and Cyst-Lining Epithelial Cells Promote Kidney Cyst Growth in -Deficient Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Yang Yang,Meihan Chen,Jie Zhou,Jiayi Lv,Shuwei Song,LiLi Fu,Jiejian Chen,Ming Yang,Changlin Mei

Carcinogenesis 36:1245-53 PubMed26246425

2015

Black raspberries suppress colonic adenoma development in ApcMin/+ mice: relation to metabolite profiles.

Applications

Unspecified application

Species

Unspecified reactive species

Pan Pan,Chad W Skaer,Hsin-Tzu Wang,Steven M Stirdivant,Matthew R Young,Kiyoko Oshima,Gary D Stoner,John F Lechner,Yi-Wen Huang,Li-Shu Wang

View all publications

style

left-column

style

left-column

style

right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Ornithine Decarboxylase/ODC antibody [ODC1/485]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ornithine Decarboxylase/ODC antibody [ODC1/485] (AB193338)

Immunocytochemistry/ Immunofluorescence - Anti-Ornithine Decarboxylase/ODC antibody [ODC1/485] (AB193338)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ornithine Decarboxylase/ODC antibody [ODC1/485] (AB193338)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ornithine Decarboxylase/ODC antibody [ODC1/485] (AB193338)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ornithine Decarboxylase/ODC antibody [ODC1/485] (AB193338)

Western blot - Anti-Ornithine Decarboxylase/ODC antibody [ODC1/485] (AB193338)

Key facts

Host species

Clonality

Clone number

Isotype

Light chain type

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (5)

Alternative Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Complementary Products

Primary Antibodies

Primary Antibodies

Secondary Antibodies

Primary Antibodies

Product promise