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AB96286

Anti-OSBPL6 antibody

1

(1 Review)

|

(2 Publications)

Rabbit Polyclonal OSBPL6 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human OSBPL6 aa 850 to C-terminus.

View Alternative Names

ORP6, OSBPL6, Oxysterol-binding protein-related protein 6, ORP-6, OSBP-related protein 6

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-OSBPL6 antibody (AB96286)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-OSBPL6 antibody (AB96286)

Immunofluorescence analysis of HeLa cells fixed in 4% paraformaldehyde at RT for 15 min labelling OSBPL6 protein at cytoplasm using ab96286 at a 1/200 dilution (Green).
Hoechst 33342 was used for nuclear staining (Blue).

Western blot - Anti-OSBPL6 antibody (AB96286)
  • WB

Supplier Data

Western blot - Anti-OSBPL6 antibody (AB96286)

Samples were separated by 7.5% SDS-PAGE.

All lanes:

Western blot - Anti-OSBPL6 antibody (ab96286) at 1/1000 dilution

All lanes:

U87-MG whole cell lysate at 30 µg

Predicted band size: 106 kDa

false

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OSBPL6 antibody (AB96286)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OSBPL6 antibody (AB96286)

1/100 ab96286 staining OSBPL6 in paraffin-embedded SCC15 tissue by immunohistochemistry.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF, IHC-P

applications

Immunogen

Synthetic Peptide within Human OSBPL6 aa 850 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9BZF3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/1000", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein OSBPL6 also known as ORP6 belongs to the oxysterol-binding protein (OSBP) family. It weighs approximately 99 kDa. OSBPL6 is ubiquitously expressed in various tissues with noticeable levels found in the brain and liver. Mechanically OSBPL6 plays a role in lipid binding and transport. Through its mechanism it regulates lipid homeostasis and may function in intracellular lipid dynamics.
Biological function summary

OSBPL6 impacts lipid metabolism and cellular signaling. It associates with membranes and may form part of a larger protein complex involved in lipid transfer between organelles. This activity impacts the way cells handle lipids and contributes to maintaining lipid balance within the cell. The identification of OSBPL6 in various cell types indicates its broad involvement in cellular activities related to lipids.

Pathways

OSBPL6 engages in lipid metabolism and regulation pathways. It is notably linked with cholesterol homeostasis and phosphoinositide signaling. OSBPL6 interacts with other members of the OSBP family potentially facilitating collaboration or competition among these proteins. These interactions highlight its significance in regulating cellular lipid environments and influencing related biological pathways.

OSBPL6's involvement shines in metabolic and neurodegenerative conditions. Altered expression or dysfunction of OSBPL6 may contribute to cholesterol-related disorders such as atherosclerosis. Furthermore disruptions in lipid regulation connected to OSBPL6 could have implications for conditions like Alzheimer's disease. In these diseases OSBPL6 might interact with proteins involved in lipid metabolism and signaling adding complexity to its role in disease contexts.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Regulates cellular transport and efflux of cholesterol (PubMed : 26941018). Plays a role in phosphatidylinositol-4-phophate (PI4P) turnover at the neuronal membrane (By similarity). Binds via its PH domain PI4P, phosphatidylinositol-4,5-diphosphate, phosphatidylinositol-3,4,5-triphosphate, and phosphatidic acid (By similarity). Weakly binds 25-hydroxycholesterol (PubMed : 17428193).
See full target information OSBPL6
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:30008 PubMed40819095

2025

Exploring the role of lipid metabolism related genes and immune microenvironment in periodontitis by integrating machine learning and bioinformatics analysis.

Applications

Unspecified application

Species

Unspecified reactive species

Lulu Wei,Miaomiao Chen,Xin Shi,Yibing Wang,Shengwei Yang

American journal of physiology. Lung cellular and molecular physiology 320:L892-L902 PubMed33355521

2020

A neutrophil subset defined by intracellular olfactomedin 4 is associated with mortality in sepsis.

Applications

Unspecified application

Species

Unspecified reactive species

Kirsten N Kangelaris,Regina Clemens,Xiaohui Fang,Alejandra Jauregui,Tom Liu,Kathryn Vessel,Thomas Deiss,Pratik Sinha,Aleksandra Leligdowicz,Kathleen D Liu,Hanjing Zhuo,Matthew N Alder,Hector R Wong,Carolyn S Calfee,Clifford Lowell,Michael A Matthay
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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