Rabbit Polyclonal OSBPL6 antibody. Suitable for WB, IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human OSBPL6 aa 850 to C-terminus.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human OSBPL6 aa 850 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q9BZF3
Reactivity data
Select an application| WB | IHC-P | |
|---|---|---|
| Human | Tested | Tested |
| Mouse | Predicted | Predicted |
| Rat | Predicted | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100.00000 - 1/254.00000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
Target data
Function
Regulates cellular transport and efflux of cholesterol (PubMed:26941018). Plays a role in phosphatidylinositol-4-phophate (PI4P) turnover at the neuronal membrane (By similarity). Binds via its PH domain PI4P, phosphatidylinositol-4,5-diphosphate, phosphatidylinositol-3,4,5-triphosphate, and phosphatidic acid (By similarity). Weakly binds 25-hydroxycholesterol (PubMed:17428193).
Alternative names
ORP6, OSBPL6, Oxysterol-binding protein-related protein 6, ORP-6, OSBP-related protein 6
Recommended products
Rabbit Polyclonal OSBPL6 antibody. Suitable for WB, IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human OSBPL6 aa 850 to C-terminus.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human OSBPL6 aa 850 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q9BZF3
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The protein OSBPL6 also known as ORP6 belongs to the oxysterol-binding protein (OSBP) family. It weighs approximately 99 kDa. OSBPL6 is ubiquitously expressed in various tissues with noticeable levels found in the brain and liver. Mechanically OSBPL6 plays a role in lipid binding and transport. Through its mechanism it regulates lipid homeostasis and may function in intracellular lipid dynamics.
- Biological function summary
OSBPL6 impacts lipid metabolism and cellular signaling. It associates with membranes and may form part of a larger protein complex involved in lipid transfer between organelles. This activity impacts the way cells handle lipids and contributes to maintaining lipid balance within the cell. The identification of OSBPL6 in various cell types indicates its broad involvement in cellular activities related to lipids.
- Pathways
OSBPL6 engages in lipid metabolism and regulation pathways. It is notably linked with cholesterol homeostasis and phosphoinositide signaling. OSBPL6 interacts with other members of the OSBP family potentially facilitating collaboration or competition among these proteins. These interactions highlight its significance in regulating cellular lipid environments and influencing related biological pathways.
- Associated diseases and disorders
OSBPL6's involvement shines in metabolic and neurodegenerative conditions. Altered expression or dysfunction of OSBPL6 may contribute to cholesterol-related disorders such as atherosclerosis. Furthermore disruptions in lipid regulation connected to OSBPL6 could have implications for conditions like Alzheimer's disease. In these diseases OSBPL6 might interact with proteins involved in lipid metabolism and signaling adding complexity to its role in disease contexts.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Western blot - Anti-OSBPL6 antibody (ab96286)
7.5% SDS PAGE
All lanes: Western blot - Anti-OSBPL6 antibody (ab96286) at 1/1000 dilution
All lanes: A431 whole cell lysate at 30 µg
Predicted band size: 106 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OSBPL6 antibody (ab96286)
1/100 ab96286 staining OSBPL6 in paraffin-embedded SCC15 tissue by immunohistochemistry.
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