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AB251678

Anti-OSCP antibody

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(1 Publication)

Rabbit Polyclonal OSCP antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ITGBL1 aa 200-400.

View Alternative Names

OSCP, TIED, ITGBL1, Integrin beta-like protein 1, Osteoblast-specific cysteine-rich protein, Ten integrin EGF-like repeat domain-containing protein

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OSCP antibody (AB251678)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OSCP antibody (AB251678)

Paraffin-embedded human lung tissue stained for OSCP using ab251678 at 1/200 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OSCP antibody (AB251678)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OSCP antibody (AB251678)

Paraffin-embedded human colorectal cancer tissue stained for OSCP using ab251678 at 1/200 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OSCP antibody (AB251678)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OSCP antibody (AB251678)

Paraffin-embedded human placenta tissue stained for OSCP using ab251678 at 1/200 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OSCP antibody (AB251678)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OSCP antibody (AB251678)

Paraffin-embedded human testis tissue stained for OSCP using ab251678 at 1/200 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human ITGBL1 aa 200-400. The exact immunogen used to generate this antibody is proprietary information.

O95965

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

OSCP also known as ATP synthase subunit O is a component of the ATP synthase complex specifically part of the F0 assembly. With a mass of approximately 23 kDa it is expressed mainly in the mitochondria where it plays an important role in energy production. By binding to the F1 domain of ATP synthase OSCP helps stabilize the complex and contribute to its function in synthesizing ATP during cellular respiration.
Biological function summary

In cellular respiration OSCP acts as a stabilizing unit within the larger ATP synthase complex. This complex is essential for the production of ATP the energy currency of the cell converting ADP and inorganic phosphate into ATP using the proton gradient generated across the mitochondrial membrane. By ensuring the structural integrity of ATP synthase OSCP facilitates efficient energy conversion necessary for cell survival and function.

Pathways

OSCP plays a role in the oxidative phosphorylation pathway which is vital for ATP production. This process involves electron transport coupled with ATP synthesis with OSCP interacting with other proteins in the complex. Notably OSCP associates with other subunits such as ATP5F1A within the same complex contributing to the regulation and maintenance of mitochondrial energy dynamics.

Faulty OSCP interactions can lead to mitochondrial dysfunctions which are connected to neurodegenerative disorders such as Alzheimer's disease. In this context OSCP's relationship with other mitochondrial proteins like Cytochrome c oxidase subunits becomes significant as such interactions might influence disease pathways and progression. Understanding OSCP's contributions offers potential pathways for targeted therapies in addressing mitochondrial-related diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information ITGBL1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell death & disease 11:151 PubMed32102992

2020

SET7/9 promotes multiple malignant processes in breast cancer development via RUNX2 activation and is negatively regulated by TRIM21.

Applications

Unspecified application

Species

Unspecified reactive species

Wenzhe Si,Jiansuo Zhou,Yang Zhao,Jiajia Zheng,Liyan Cui
View all publications
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Product promise

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