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AB68793

Anti-OSGIN1 antibody

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(2 Publications)

Mouse Polyclonal OSGIN1 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human OSGIN1.

View Alternative Names

BDGI, OKL38, OSGIN1, Oxidative stress-induced growth inhibitor 1, Bone marrow stromal cell-derived growth inhibitor, Pregnancy-induced growth inhibitor OKL38, BMSC-derived growth inhibitor, huOKL38

1 Images
Western blot - Anti-OSGIN1 antibody (AB68793)
  • WB

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Western blot - Anti-OSGIN1 antibody (AB68793)

All lanes:

Western blot - Anti-OSGIN1 antibody (ab68793) at 1/500 dilution

Lane 1:

OSGIN1 transfected 293T cell lysate at 25 µg

Lane 2:

Non-transfected 293T cell lysate at 25 µg

Secondary

All lanes:

Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Predicted band size: 61 kDa

Observed band size: 52 kDa

false

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human OSGIN1.

Q9UJX0

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The OSGIN1 gene also known as Oxidative Stress Induced Growth Inhibitor 1 encodes a protein that weighs approximately 56 kDa. This protein plays an important role in cellular response to oxidative stress. It is expressed in various tissues including the liver kidney and brain. The OSGIN1 protein functions by inducing apoptosis when oxidative stress is detected aiding the cell in managing damage from reactive oxygen species.
Biological function summary

The ability of OSGIN1 to regulate cell death allows it to maintain cellular homeostasis. This protein does not operate as part of a complex but performs its functions by altering the transcription of specific genes involved in cell growth and death. By modulating genes linked to oxidative damage OSGIN1 controls balance between cell survival and apoptosis thereby influencing cell fate in stressful environments.

Pathways

OSGIN1 plays a significant role in the oxidative stress response pathway by interacting with key proteins such as p53 and Nrf2. These interactions facilitate the antioxidant responses of cells. By promoting p53-mediated apoptosis and Nrf2-related antioxidant gene expression OSGIN1 helps in protecting cells from oxidative damage contributing to the proper functioning of related pathways.

The dysregulation of OSGIN1 is associated with conditions like cancer and neurodegenerative diseases. Aberrant expression of OSGIN1 can lead to either excessive cell death or survival contributing to tumorigenesis in various cancers. Additionally in neurodegenerative disorders OSGIN1 dysfunction can disrupt neuronal survival. The protein connects with dysregulated p53 activity in cancer and Nrf2 pathway alterations in neurodegenerative diseases influencing disease progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Regulates the differentiation and proliferation through the regulation of cell death.
See full target information OSGIN1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

NPJ precision oncology 9:15 PubMed39809873

2025

A targetable OSGIN1 - AMPK - SLC2A3 axis controls the vulnerability of ovarian cancer to ferroptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Mengqi Deng,Fan Tang,Xiangyu Chang,Yanqin Zhang,Penglin Liu,Xuechao Ji,Yubo Zhang,Ruiye Yang,Junyi Jiang,Junqi He,Jinwei Miao

Nucleic acids research 40:8721-32 PubMed22735705

2012

Structural analysis and dimerization profile of the SCAN domain of the pluripotency factor Zfp206.

Applications

Unspecified application

Species

Unspecified reactive species

Yu Liang,Felicia Huimei Hong,Pugalenthi Ganesan,Sizun Jiang,Ralf Jauch,Lawrence W Stanton,Prasanna R Kolatkar
View all publications
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