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AB106082

Anti-OspB antibody

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(1 Publication)

Rabbit Polyclonal OSPB antibody. Suitable for WB and reacts with Recombinant fragment - Borreliella burgdorferi samples. Cited in 1 publication. Immunogen corresponding to Recombinant Protein within Borreliella burgdorferi B31 ospB.

View Alternative Names

BB_A16, ospB, Outer surface protein B, Outer surface protein B

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Borreliella burgdorferi

Applications

WB

applications

Immunogen

Recombinant Protein within Borreliella burgdorferi B31 ospB. The exact immunogen used to generate this antibody is proprietary information.

P17739

Specificity

<p>A BLAST analysis was used to suggest cross-reactivity with OspB from B. burgdorferi, afzelii, spielmanii, and garinii sources based on 100% homology with the immunizing sequence, and with B. valaisiana based on 99% homology. Cross-reactivity with OspB from other sources has not been determined.</p>

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Complementary Products

Primary Antibodies

AB106083

Anti-ospC antibody

Western blot - Anti-ospC antibody (AB106083)

  • 0
  • 0
Primary Antibodies

AB106081

Anti-ospA antibody

Western blot - Anti-ospA antibody (AB106081)

  • 0
  • 0
Primary Antibodies

AB69219

Anti-Borrelia burgdorferi antibody

  • 0
  • 0
Sample Prep & Detection Kits

AB201808

Gold Conjugation Kit (10 nm, 20 OD)

Conjugation - Gold Conjugation Kit (10 nm, 20 OD) (AB201808)

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  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Borreliella burgdorferi": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Recombinant fragment - Borreliella burgdorferi": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Purification notes
This product was Protein-A purified and cross-adsorbed against MBP from monospecific antiserum by chromatography.
Storage buffer
Preservative: 0.01% Sodium azide Constituents: 0.88% Sodium chloride, 0.424% Potassium phosphate solution
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

OspB also known as Outer Surface Protein B is an important component of certain bacterial membranes particularly distinguished in Borrelia burgdorferi the causative agent of Lyme disease. The protein has a molecular mass of approximately 43 kDa. It is expressed predominantly on the outer surface of these spirochetes which serves as a physical barrier and an interaction point between the bacterium and its host environment. Its structural role is significant in the integrity and function of the bacterial outer membrane.
Biological function summary

This protein plays a significant role in promoting bacterial adhesion and immune evasion. OspB forms part of a complex with other outer surface proteins such as OspA which cooperatively assists the bacteria to persist within the tick vector and mammalian host. By forming these protein complexes OspB contributes to the pathogen's ability to resist removal by host immune mechanisms facilitating long-term survival and transmission.

Pathways

OspB interacts closely with immune modulation and pathogen adhesion pathways. These interactions include the inhibition of the host's complement activation pathway an important process for immune defense. By bypassing this pathway the protein helps the bacteria avoid phagocytosis and clearance. OspB displays functional links with proteins like OspC another surface protein which together enhance the survival and colonization efficiency of Borrelia burgdorferi.

OspB is critically linked to Lyme disease. The protein's role in immune evasion and adhesion significantly impacts the disease's progression particularly in the establishment and persistence of infection. OspB's interactions with proteins such as decorin-binding proteins and integrins on host cells highlight its contributions to disease mechanisms. These interactions influence inflammation and tissue invasion core aspects of Lyme disease pathology.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information ospB

Additional targets

OspB
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The journal of gene medicine 25:e3552 PubMed37337736

2023

B4GALNT1 promotes carcinogenesis by regulating epithelial-mesenchymal transition in hepatocellular carcinoma based on pan-cancer analysis.

Applications

Unspecified application

Species

Unspecified reactive species

Wenli Liu,Yutong Chen,Jinqiang Yang,Mingliang Guo,Li Wang
View all publications
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Product promise

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