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AB106083

Anti-ospC antibody

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(1 Publication)

Rabbit Polyclonal OSPC antibody. Suitable for WB and reacts with Recombinant fragment - Borreliella burgdorferi samples. Cited in 1 publication. Immunogen corresponding to Recombinant Protein within Borreliella burgdorferi B31 ospC.

View Alternative Names

BB_B19, ospC, Outer surface protein C, pC, P23, Outer surface protein C

1 Images
Western blot - Anti-ospC antibody (AB106083)
  • WB

Supplier Data

Western blot - Anti-ospC antibody (AB106083)

4-20% gel.

All lanes:

Western blot - Anti-ospC antibody (ab106083) at 1/1000 dilution

Lane 1:

MBP-ospC fusion protein at 0.1 µg

Lane 2:

MBP alone at 0.1 µg

Secondary

All lanes:

Goat-anti-Rabbit HRP at 1/40000 dilution

Predicted band size: 22 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Borreliella burgdorferi

Applications

WB

applications

Immunogen

Recombinant Protein within Borreliella burgdorferi B31 ospC. The exact immunogen used to generate this antibody is proprietary information.

Q07337

Specificity

This antibody is specific for Borrelia burgdorferi OspC protein. A BLAST analysis was used to suggest cross-reactivity with p39 from B. burgdorferi, afzelii, and valaisiana sources based on 100% homology with the immunizing sequence. Partial reactivity is expected against B. japonica and americana sources based on 94% homology. Cross-reactivity with OspC from other sources has not been determined.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Borreliella burgdorferi": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Recombinant fragment - Borreliella burgdorferi": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Purification notes
ab106083 is cross-adsorbed against MBP from monospecific antiserum by chromatography.
Storage buffer
Preservative: 0.01% Sodium azide Constituents: 0.88% Sodium chloride, 0.424% Potassium phosphate solution
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The 'OspC' also known as 'OspC Borrelia' is an outer surface protein with a molecular mass of approximately 22 kDa. It is expressed on the surface of Borrelia species including Borrelia burgdorferi which is the bacterium responsible for Lyme disease. OspC plays a mechanical role in the early stages of Borrelia infection and is important for the survival of the bacterium in the host.
Biological function summary

This protein is essential for Borrelia to establish infection within a mammalian host. OspC belongs to a group of proteins that facilitate the evasion of the host's immune response. It operates as part of a complex that interacts with host factors enhancing the bacterium's ability to disseminate through the host tissue. By enabling the pathogen to adhere to host cells OspC promotes the successful colonization of the host.

Pathways

OspC interacts with factors involved in host immune pathways including evasion mechanisms. It is linked to the complement evasion pathway helping Borrelia to resist destruction by the host's complement system. Additionally OspC shares pathway interactions with other surface proteins like OspA and DbpA (decorin-binding protein A) which also aid in immune evasion and tissue adherence.

OspC is directly associated with Lyme disease where its expression leads to the early stages of infection and symptom development. By masking the bacterium from the immune system OspC allows Borrelia to spread leading to the multisystemic symptoms typical in Lyme disease. Additionally OspC interacts with proteins such as fibronectin-binding proteins which might contribute to the severity of the disease's manifestations. This relationship emphasizes the potential of OspC as a target for diagnostic and therapeutic strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

A major immunodominant protein in mammalian hosts (PubMed : 8098841, PubMed : 8225587, PubMed : 8478109). Required for the initial stages of mammalian infection (PubMed : 14970347, PubMed : 16714588, PubMed : 20199597, PubMed : 28873507). Interaction with tick I.ricinus salivary protein Salp15 protects the bacteria from antibody-mediated killing in vitro and in vivo (PubMed : 18752445). Inhibits macrophage-mediated phagocytosis of the bacteria (PubMed : 26438793). Binds human plasminogen; this probably confers an extracellular protease activity on the bacteria that allows it to traverse tissue (PubMed : 20199597, PubMed : 22433849). Binds human complement C4-B, which may inhibit the complement cascade (Probable) (PubMed : 28873507). Experiments in mice suggest it may play another role after initial infection (Probable) (PubMed : 27611840).
See full target information ospC
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The journal of gene medicine 25:e3552 PubMed37337736

2023

B4GALNT1 promotes carcinogenesis by regulating epithelial-mesenchymal transition in hepatocellular carcinoma based on pan-cancer analysis.

Applications

Unspecified application

Species

Unspecified reactive species

Wenli Liu,Yutong Chen,Jinqiang Yang,Mingliang Guo,Li Wang
View all publications
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