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AB167167

Anti-OTOP2 antibody [EPR9484]

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(1 Publication)

Rabbit Recombinant Monoclonal OTOP2 antibody. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.

View Alternative Names

Proton channel OTOP2, Otopetrin-2, OTOP2

2 Images
Flow Cytometry (Intracellular) - Anti-OTOP2 antibody [EPR9484] (AB167167)
  • Flow Cyt (Intra)

Unknown

Flow Cytometry (Intracellular) - Anti-OTOP2 antibody [EPR9484] (AB167167)

Intracellular flow cytometric analysis of permeabilized U-87 MG cells labeling OTOP2 with ab167167 (red) or a rabbit IgG (negative) (green).

Western blot - Anti-OTOP2 antibody [EPR9484] (AB167167)
  • WB

Unknown

Western blot - Anti-OTOP2 antibody [EPR9484] (AB167167)

All lanes:

Western blot - Anti-OTOP2 antibody [EPR9484] (ab167167) at 1/1000 dilution

Lane 1:

Human fetal heart lysates at 10 µg

Lane 2:

Human spleen lysates at 10 µg

Lane 3:

U-87MG cell lysates at 10 µg

Lane 4:

Human fetal thymus lysates at 10 µg

Secondary

All lanes:

Goat anti-rabbit HRP at 1/2000 dilution

Predicted band size: 62 kDa

false

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR9484

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

Flow Cyt (Intra), WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "FlowCytIntra" : {"fullname" : "Flow Cytometry (Intracellular)", "shortname":"Flow Cyt (Intra)"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "FlowCytIntra-species-checked": "testedAndGuaranteed", "FlowCytIntra-species-dilution-info": "1/10 - 1/100", "FlowCytIntra-species-notes": "<p><a href='/en-us/products/primary-antibodies/rabbit-igg-monoclonal-epr25a-isotype-control-ab172730'>ab172730</a> - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.</p>" }, "Mouse": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "FlowCytIntra-species-checked": "predicted", "FlowCytIntra-species-dilution-info": "", "FlowCytIntra-species-notes": "" }, "Rat": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "FlowCytIntra-species-checked": "predicted", "FlowCytIntra-species-dilution-info": "", "FlowCytIntra-species-notes": "" } } }
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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purity
Tissue culture supernatant
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein OTOP2 also known as Otopetrin 2 is involved in proton channel activity. It has an approximate molecular mass of 70 kDa. OTOP2 expresses in various tissues including the vestibular system and other sensory organs. Its role involves contributing to chemical gradients helping with cellular processes within these systems. This expression pattern points to its relevance in sensory functions mainly in maintaining balance and spatial orientation.
Biological function summary

OTOP2 influences ion balance in cells. This protein participates in cellular activities by modulating pH and ionic concentrations. OTOP2 often functions on its own without being part of larger protein complexes to achieve its regulatory roles. Its activity ensures cells maintain an environment that supports normal cellular operations and signaling particularly in response to external stimuli.

Pathways

OTOP2 plays a role in ion transport and sensory perception pathways. It aligns with key proteins involved in sensory signaling such as OTOP1 and OTOP3 which participate in similar sensory activities. This association indicates that OTOP2 functions in the contribution to sensory signal transduction. The involvement in these pathways highlights its importance in the body's response to sensory input and environmental changes.

OTOP2 connects to balance disorders like vestibular dysfunctions. Such conditions are due to the malfunction of sensory signaling related to balance. Proteins such as OTOP1 are similarly linked in these disorders emphasizing their collective importance in vestibular health. Additionally understanding how OTOP2 works can inform research into improved treatments for these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Proton-selective ion channel open at neutral pH. Actives at neutral and alkaline extracellular pH, likely participates in some alkali-related physiological activities.
See full target information Proton channel OTOP2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Human molecular genetics 32:1922-1931 PubMed36881658

2023

Nicotinamide riboside rescues dysregulated glycolysis and fatty acid β-oxidation in a human hepatic cell model of citrin deficiency.

Applications

Unspecified application

Species

Unspecified reactive species

Winifred W Yau,Gao Bin Chen,Jin Zhou,Joel Celio Francisco,Nivetha Kanakaram Thimmukonda,Shang Li,Brijesh Kumar Singh,Paul Michael Yen
View all publications
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Product promise

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For full details, please see our Terms & Conditions

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