AB198781

Anti-Otoraplin antibody - C-terminal

Name: Anti-Otoraplin antibody - C-terminal (ab198781) | Abcam
Brand: Abcam Limited
SKU: AB198781

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(1 Publication)

Rabbit Polyclonal Otoraplin antibody. C-terminal. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human OTOR.

View Alternative Names

FDP, MIAL, UNQ3054/PRO9873, OTOR, Otoraplin, Fibrocyte-derived protein, Melanoma inhibitory activity-like protein

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Otoraplin antibody - C-terminal (AB198781)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Otoraplin antibody - C-terminal (AB198781)

Immunohistochemical analysis of paraffin-embedded Human ovarian cancer tissue labeling Otoraplin with ab198781 at 1/30 dilution.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Otoraplin antibody - C-terminal (AB198781)

Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue labeling Otoraplin with ab198781 at 1/30 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human OTOR. The exact immunogen used to generate this antibody is proprietary information.

Q9NRC9

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Otoraplin also known as Otoraplin A is a protein with a molecular mass of approximately 14 kDa. It belongs to the fibroblast growth factor (FGF) family and is mainly expressed in the ear especially in the cochlear and vestibular tissues. Otoraplin acts mechanically through its involvement in cellular signaling processes. Although studied less extensively its presence in neural tissues indicates that it might contribute to the developing auditory and equilibrium systems.

Biological function summary

This protein assists in cell proliferation survival and differentiation within ear tissues. The precise role is not fully determined yet but its membership in the protein family suggests that it might interact with others in similar contexts. Otoraplin does not seem part of a large complex but likely still has interactions as part of signaling networks important to tissue maintenance and function.

Pathways

Otoraplin appears implicated in the fibroblast growth factor signaling pathway. This pathway is essential for various cellular processes including development and wound healing. In this pathway proteins like FGFR1 (Fibroblast Growth Factor Receptor 1) interact closely with Otoraplin indicating a potential collaborative role in signal cascade events which lead to desired cellular outcomes.

Research so far associates Otoraplin with otosclerosis a condition affecting bone growth in the ear and hearing loss. Abnormal regulation or expression of Otoraplin might disrupt normal ear tissue processes potentially causing these conditions. The involvement of FGFR1 in similar disorders further suggests that Otoraplin might play a relevant role in the pathological development associated with these auditory impairments.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

See full target information OTOR

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cancers 13: PubMed34885090

2021

MiR-195 and Its Target SEMA6D Regulate Chemoresponse in Breast Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Diana E Baxter,Lisa M Allinson,Waleed S Al Amri,James A Poulter,Arindam Pramanik,James L Thorne,Eldo T Verghese,Thomas A Hughes

View all publications

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Product promise

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For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-Otoraplin antibody - C-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Otoraplin antibody - C-terminal (AB198781)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Otoraplin antibody - C-terminal (AB198781)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

Complementary Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

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