AB122481

Anti-OTUD1 antibody

Name: Anti-OTUD1 antibody (ab122481) | Abcam
Brand: Abcam Limited
SKU: AB122481
Price: 645 USD
Availability: InStock

(1 Review)

(17 Publications)

Rabbit Polyclonal OTUD1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 17 publications. Immunogen corresponding to Recombinant Fragment Protein within Human OTUD1 aa 250-400.

View Alternative Names

DUBA7, OTDC1, OTUD1, OTU domain-containing protein 1, DUBA-7

4 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OTUD1 antibody (AB122481)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OTUD1 antibody (AB122481)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of liver tissue labelling OTUD1 with ab122481 at 1/50 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OTUD1 antibody (AB122481)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of lung tissue labelling OTUD1 with ab122481 at 1/50 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OTUD1 antibody (AB122481)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of lymph node tissue labelling OTUD1 with ab122481 at 1/50 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OTUD1 antibody (AB122481)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of duodenum tissue labelling OTUD1 with ab122481 at 1/50 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human OTUD1 aa 250-400. The exact immunogen used to generate this antibody is proprietary information.

Q5VV17

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/50", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

OTUD1 also known as OTU domain-containing protein 1 functions as a deubiquitinating enzyme. This protein exhibits a mass of approximately 50 kDa and importantly removes ubiquitin molecules from specific protein targets. Expression of OTUD1 occurs in various tissues with significant levels detected in the liver pancreas and lung. The presence in different tissues suggests its versatile roles in cellular processes.

Biological function summary

OTUD1 stabilizes proteins involved in cell signaling and immune responses. It participates in complexes that regulate cell proliferation and apoptosis indicating its importance in maintaining cellular homeostasis. Through its deubiquitinating action OTUD1 influences the degradation of proteins by the proteasome affecting key cellular pathways. Its interactions in these complexes highlight its regulatory significance in cellular dynamics.

Pathways

The function of OTUD1 integrates into the NF-kB signaling and DNA damage repair pathways. It interacts with proteins like TRAF6 and p53 modulating their stability and activity. The connection to NF-kB signaling implicates OTUD1 in regulating inflammatory responses while involvement in DNA damage repair associates it with genomic integrity maintenance. These interactions emphasize its role in significant cellular pathways.

Implications of OTUD1 relate to cancer and autoimmune diseases. Alterations in OTUD1 expression or function could contribute to tumor progression potentially through disrupted regulation of proteins like p53. Additionally its role in inflammatory responses has potential links to autoimmune disorders. Understanding its interaction with proteins involved in these conditions may provide insights into therapeutic strategies.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
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Target data

Deubiquitinating enzyme that specifically hydrolyzes 'Lys-63'-linked polyubiquitin to monoubiquitin (PubMed : 23827681). Required for the stability and translation of a subset mRNAs with a high abundance of rare codons by mediating deubiquitination of 40S ribosomal protein RPS10/eS10, thereby antagonizing ZNF598-mediated 40S ubiquitination (PubMed : 36445135). The abundance of rare codons in mRNAs can limit the translation rate and can lead to ribosome collisions that trigger activation of ribosome quality control (RQC) pathway by ZNF598 (PubMed : 36445135). OTUD1-mediated deubiquitination prevents activation of the RQC and subsequent dissociation of ribosomes and stimulates formation of polysomes and translation (PubMed : 36445135).

See full target information OTUD1

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Publications (17)

Recent publications for all applications. Explore the full list and refine your search

Journal of neuroinflammation 22:154 PubMed40500776

2025

OTUD1 exacerbates sepsis-associated encephalopathy by promoting HK2 mitochondrial release to drive microglia pyroptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Guoqing Jing,Hailong Gong,Han Wang,Jing Zuo,Die Wu,Huifan Liu,Xing Wang,Min Yuan,Yun Xia,Tongtong Du,Wanhong Liu,Xiaojing Wu,Xuemin Song

Oncogene 44:1731-1745 PubMed40108305

2025

A positive feedback loop of OTUD1 and c-Jun driven by leptin expedites stemness maintenance in ovarian cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Jingtao Wang,Fan Yang,Yurou Chen,Yuzhu Xing,Juyuan Huang,Jing Cao,Jiaqiang Xiong,Yanyan Liu,Qiuyan Zhao,Manwen Luo,Jie Xiong,Guanlan Fan,Qiongying Lyu,Feng Li,Wei Zhang

Viruses 17: PubMed40007014

2025

The Deubiquitinase OTUD1 Influences HIV-1 Release by Regulating the Host Restriction Factor BST-2.

Applications

Unspecified application

Species

Unspecified reactive species

Man-Di Zhang,Fan Chen,Wen-Qiang He,Ying Lu,Feng-Liang Liu,Hong-Guang Zhang,Liu-Meng Yang,Chun-Sheng Dong,Si-Dong Xiong,Yong-Tang Zheng

Poultry science 103:104382 PubMed39437555

2024

OTUD1 regulates cytokine expression and related pathways in goose fatty liver by promoting deubiquitination of its target proteins.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoyi Zhou,Ya Xing,Yuqing Wang,Mengqing Lv,Pei Zhang,Suyan Zhu,Jing Ge,Long Liu,Minmeng Zhao,Haizhou Gong,Daoqing Gong,Tuoyu Geng

Redox biology 75:103287 PubMed39079388

2024

The deubiquitinase OTUD1 stabilizes NRF2 to alleviate hepatic ischemia/reperfusion injury.

Applications

Unspecified application

Species

Unspecified reactive species

Qi Zhang,Zihan Chen,Jinglei Li,Kunpeng Huang,Zhihao Ding,Biao Chen,Tianxing Ren,Peng Xu,Guoliang Wang,Hongji Zhang,Xiao-Dong Zhang,Jinxiang Zhang,Hui Wang

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 10:e2303207 PubMed37639212

2023

The Deubiquitinase OTUD1 Suppresses Secretory Neutrophil Polarization And Ameliorates Immunopathology of Periodontitis.

Applications

Unspecified application

Species

Unspecified reactive species

Jia Song,Yuning Zhang,Yunyang Bai,Xiaowen Sun,Yanhui Lu,Yusi Guo,Ying He,Min Gao,Xiaopei Chi,Boon Chin Heng,Xin Zhang,Wenjing Li,Mingming Xu,Yan Wei,Fuping You,Xuehui Zhang,Dan Lu,Xuliang Deng

Cellular oncology (Dordrecht) 46:1001-1014 PubMed36929488

2023

VE-822 upregulates the deubiquitinase OTUD1 to stabilize FHL1 to inhibit the progression of lung adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Qi Zhang,Jinglei Li,Zihan Chen,Ke Jiang,Kunyu Yang,Fang Huang,Ai Huang,Xiaodong Zhang,Jinxiang Zhang,Hui Wang

Molecular and cellular biology 42:e0026522 PubMed36445135

2022

Deubiquitinase OTUD1 Resolves Stalled Translation on polyA and Rare Codon Rich mRNAs.

Applications

Unspecified application

Species

Unspecified reactive species

Renata Snaurova,Alexander Vdovin,Michal Durech,Jakub Nezval,David Zihala,Tomas Jelinek,Roman Hajek,Michal Simicek

Cell research 32:897-913 PubMed35821088

2022

Depression compromises antiviral innate immunity via the AVP-AHI1-Tyk2 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Hong-Guang Zhang,Bin Wang,Yong Yang,Xuan Liu,Junjie Wang,Ning Xin,Shifeng Li,Ying Miao,Qiuyu Wu,Tingting Guo,Yukang Yuan,Yibo Zuo,Xiangjie Chen,Tengfei Ren,Chunsheng Dong,Jun Wang,Hang Ruan,Miao Sun,Xingshun Xu,Hui Zheng

Thoracic cancer 13:761-770 PubMed35098684

2022

The deubiquitinase OTUD1 inhibits non-small cell lung cancer progression by deubiquitinating and stabilizing KLF4.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoyan Ma,Liming Wang,Guifang Shi,Shuqing Sun

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-OTUD1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OTUD1 antibody (AB122481)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OTUD1 antibody (AB122481)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OTUD1 antibody (AB122481)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OTUD1 antibody (AB122481)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (17)

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Primary Antibodies

Primary Antibodies

Primary Antibodies

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