Anti-OTUD3 Antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

OTUD3 also known as OTU Domain-Containing Protein 3 is a deubiquitinating enzyme that belongs to the OTU family. It has a molecular mass of approximately 48 kDa. OTUD3 is involved in removing ubiquitin from specific protein substrates impacting their degradation activity or localization. This protein is widely expressed in various tissues including the liver kidney and brain suggesting its roles in multiple physiological processes.

Biological function summary

OTUD3 is essential in regulating protein homeostasis and cellular signaling. It is part of protein complexes that modulate ubiquitination pathways maintaining proper protein turnover and function. By deubiquitinating target proteins OTUD3 can influence processes like cell cycle progression apoptosis and DNA repair. The enzyme's regulation of these pathways highlights its role in maintaining cellular health.

Pathways

OTUD3 influences key signaling cascades such as the NF-kB and p53 pathways. In the NF-kB pathway OTUD3 interacts with proteins like TRAF3 modulating inflammation and immune responses. Similarly in the p53 pathway it can impact the stability and activity of p53 protein which is critical for cell cycle regulation and apoptosis. The relationship of OTUD3 with these pathways indicates its importance in cell signaling and stress responses.

Associated diseases and disorders

OTUD3 is connected to cancer and neurodegenerative diseases. Altered expression or activity of OTUD3 can contribute to tumorigenesis with changes seen in cancers like breast and lung cancer. OTUD3 is also linked to neurodegenerative conditions through its interaction with proteins like Parkin an important player in Parkinson's disease. Understanding the roles of OTUD3 in these diseases can guide therapeutic strategies and target designs.