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Rabbit Polyclonal OVGP1/OGP antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human OVGP1.


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Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 99% PBS

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Synthetic Peptide within Human OVGP1. The exact immunogen used to generate this antibody is proprietary information. Database link Q12889
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Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
IHC-P
Human
Tested
Rat
Predicted

Tested
Tested

Species

Human

Dilution info

5 µg/mL

Notes

-

Predicted
Predicted

Species

Rat

Dilution info

-

Notes

-

Target data

Function

Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development.

Alternative names

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Rabbit Polyclonal OVGP1/OGP antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human OVGP1.

Alternative names

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen

Synthetic Peptide within Human OVGP1. The exact immunogen used to generate this antibody is proprietary information.Database link Q12889

Purification technique

Affinity purification Immunogen

Concentration
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Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

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Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

Biological summary

OVGP1 plays an important role in reproduction. It interacts with the zona pellucida and helps facilitate sperm binding and penetration enhancing fertilization potential. The protein is not part of a large complex but is known for modifying the environment in the oviduct to support fertility. It also maintains the stability and permeability of the oocyte and embryo matrix impacting early stages of embryo development.

Mechanical summary

OVGP1 also known as oviductal glycoprotein or OGP is a glycoprotein with a molecular mass around 120 kDa. This protein is expressed mainly in the oviduct epithelium in mammals. It is secreted during the peri-ovulatory phase and associates with the zona pellucida and the oocyte. OGP products are studied extensively due to their role in reproductive biology especially concerning fertilization and early embryonic development.

Pathway

OVGP1 influences reproductive pathways that involve sperm-egg interaction and embryo transport. The glycoprotein acts along pathways connected to fertilization affecting the zona pellucida's structural and functional properties which are also influenced by proteins like ZP3 (zona pellucida glycoprotein 3). These pathways ensure that the conditions in the oviduct are optimal for successful conception and embryo support.

Disease

OVGP1 has been linked to infertility and reproductive challenges. Altered expression or dysfunction of this protein can affect fertility contributing to conditions like fallopian tube disorders and ectopic pregnancies. It might also interact with other proteins related to infertility such as inhibin affecting its pathways and mechanisms. Understanding these interactions provides insight into the treatment and management of reproductive health issues.

Product promise

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1 product image

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OVGP1/OGP antibody (ab118590), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OVGP1/OGP antibody (ab118590)

    ab118590, at 5 μg/ml, staining OVGP1/OGP in formalin fixed, paraffin embedded Human fallopian tube by Immunohistochemistry.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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