AB74544

Anti-OVGP1/OGP antibody

Name: Anti-OVGP1/OGP antibody (ab74544) | Abcam
Brand: Abcam Limited
SKU: AB74544
Price: 525 USD
Availability: InStock

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(6 Publications)

Rabbit Polyclonal OVGP1/OGP antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human OVGP1.

View Alternative Names

MUC9, OGP, OVGP1, Oviduct-specific glycoprotein, Estrogen-dependent oviduct protein, Mucin-9, Oviductal glycoprotein, Oviductin

3 Images

Immunocytochemistry/ Immunofluorescence - Anti-OVGP1/OGP antibody (AB74544)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-OVGP1/OGP antibody (AB74544)

PFA-fixed, Triton X-100 permeabilized HEK-293 (human epithelial cell line from embryonic kidney) cells stained for OVGP1/OGP using ab74544 at 2.5 μg/ml in ICC/IF.

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-OVGP1/OGP antibody (AB74544)

PFA-fixed, Triton X-100 permeabilized HEK-293 (human epithelial cell line from embryonic kidney) cells stained for OVGP1/OGP (green) using ab74544 at 5 μg/ml in ICC/IF.

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Western blot - Anti-OVGP1/OGP antibody (AB74544)

All lanes:

Western blot - Anti-OVGP1/OGP antibody (ab74544) at 1 µg/mL

All lanes:

human placenta tissue lysate

Predicted band size: 75 kDa

Observed band size: 150 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Synthetic Peptide within Human OVGP1. The exact immunogen used to generate this antibody is proprietary information.

Q12889

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "20 µg/mL", "ICCIF-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

OVGP1 also known as oviductal glycoprotein or OGP is a glycoprotein with a molecular mass around 120 kDa. This protein is expressed mainly in the oviduct epithelium in mammals. It is secreted during the peri-ovulatory phase and associates with the zona pellucida and the oocyte. OGP products are studied extensively due to their role in reproductive biology especially concerning fertilization and early embryonic development.

Biological function summary

OVGP1 plays an important role in reproduction. It interacts with the zona pellucida and helps facilitate sperm binding and penetration enhancing fertilization potential. The protein is not part of a large complex but is known for modifying the environment in the oviduct to support fertility. It also maintains the stability and permeability of the oocyte and embryo matrix impacting early stages of embryo development.

Pathways

OVGP1 influences reproductive pathways that involve sperm-egg interaction and embryo transport. The glycoprotein acts along pathways connected to fertilization affecting the zona pellucida's structural and functional properties which are also influenced by proteins like ZP3 (zona pellucida glycoprotein 3). These pathways ensure that the conditions in the oviduct are optimal for successful conception and embryo support.

OVGP1 has been linked to infertility and reproductive challenges. Altered expression or dysfunction of this protein can affect fertility contributing to conditions like fallopian tube disorders and ectopic pregnancies. It might also interact with other proteins related to infertility such as inhibin affecting its pathways and mechanisms. Understanding these interactions provides insight into the treatment and management of reproductive health issues.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development.

See full target information OVGP1

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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

PloS one 17:e0271584 PubMed35921335

2022

Single-cell analysis of a high-grade serous ovarian cancer cell line reveals transcriptomic changes and cell subpopulations sensitive to epigenetic combination treatment.

Applications

Unspecified application

Species

Unspecified reactive species

Shruthi Sriramkumar,Tara X Metcalfe,Tim Lai,Xingyue Zong,Fang Fang,Heather M O'Hagan,Kenneth P Nephew

Histology and histopathology 34:1243-1254 PubMed30964151

2019

Unique expression profiles of mucin proteins in interstitial pneumonia-associated lung adenocarcinomas.

Applications

Unspecified application

Species

Unspecified reactive species

Toshiaki Kataoka,Koji Okudela,Yu Nakashima,Hideaki Mitsui,Mai Matsumura,Shigeaki Umeda,Hiromasa Arai,Tomohisa Baba,Takehisa Suzuki,Chihiro Koike,Yoko Tateishi,Michihiko Tajiri,Tamiko Takemura,Takashi Ogura,Munetaka Masuda,Kenichi Ohashi

Journal of assisted reproduction and genetics 35:1419-1429 PubMed29968069

2018

Oviductal glycoprotein 1 (OVGP1) is expressed by endometrial epithelium that regulates receptivity and trophoblast adhesion.

Applications

Unspecified application

Species

Unspecified reactive species

Saniya Laheri,Nancy Ashary,Purvi Bhatt,Deepak Modi

PloS one 13:e0198843 PubMed29906278

2018

Influence of elevated temperature on bovine oviduct epithelial cells (BOECs).

Applications

Unspecified application

Species

Unspecified reactive species

Łukasz Rąpała,Rafał R Starzyński,Piotr Z Trzeciak,Sebastian Dąbrowski,Małgorzata Gajewska,Piotr Jurka,Roman Smolarczyk,Anna M Duszewska

PloS one 8:e65067 PubMed23741457

2013

Conditional inactivation of p53 in mouse ovarian surface epithelium does not alter MIS driven Smad2-dominant negative epithelium-lined inclusion cysts or teratomas.

Applications

IHC-P

Species

Mouse

Suzanne M Quartuccio,Daniel D Lantvit,Maarten C Bosland,Joanna E Burdette

Human reproduction (Oxford, England) 26:1422-30 PubMed21421661

2011

Ovarian surface epitheliectomy in the non-human primate: continued cyclic ovarian function and limited epithelial replacement.

Applications

Unspecified application

Species

Unspecified reactive species

Jay W Wright,Tanja Pejovic,Leigh Jurevic,Cecily V Bishop,Theodore Hobbs,Richard L Stouffer

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-OVGP1/OGP antibody

Immunocytochemistry/ Immunofluorescence - Anti-OVGP1/OGP antibody (AB74544)

Immunocytochemistry/ Immunofluorescence - Anti-OVGP1/OGP antibody (AB74544)

Western blot - Anti-OVGP1/OGP antibody (AB74544)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

Primary Antibodies

Complementary Products

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (6)

Product promise