Rabbit Polyclonal OVGP1/OGP antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human OVGP1.
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- PloS one 17:e02715842022Single-cell analysis of a high-grade serous ovarian cancer cell line reveals transcriptomic changes and cell subpopulations sensitive to epigenetic combination treatment.Applications:Unspecified applicationReactive species:Unspecified reactive speciesShruthi Sriramkumar,Tara X Metcalfe,Tim Lai,Xingyue Zong,Fang Fang,Heather M O'Hagan,Kenneth P NephewPubMed 35921335
- Histology and histopathology 34:1243-12542019Unique expression profiles of mucin proteins in interstitial pneumonia-associated lung adenocarcinomas.Applications:Unspecified applicationReactive species:Unspecified reactive speciesToshiaki Kataoka et. al.PubMed 30964151
- Journal of assisted reproduction and genetics 35:1419-14292018Oviductal glycoprotein 1 (OVGP1) is expressed by endometrial epithelium that regulates receptivity and trophoblast adhesion.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSaniya Laheri et. al.PubMed 29968069
- PloS one 13:e01988432018Influence of elevated temperature on bovine oviduct epithelial cells (BOECs).Applications:Unspecified applicationReactive species:Unspecified reactive speciesŁukasz Rąpała,Rafał R Starzyński,Piotr Z Trzeciak,Sebastian Dąbrowski,Małgorzata Gajewska,Piotr Jurka,Roman Smolarczyk,Anna M DuszewskaPubMed 29906278
- PloS one 8:e650672013Conditional inactivation of p53 in mouse ovarian surface epithelium does not alter MIS driven Smad2-dominant negative epithelium-lined inclusion cysts or teratomas.
- Human reproduction (Oxford, England) 26:1422-302011Ovarian surface epitheliectomy in the non-human primate: continued cyclic ovarian function and limited epithelial replacement.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJay W Wright,Tanja Pejovic,Leigh Jurevic,Cecily V Bishop,Theodore Hobbs,Richard L StoufferPubMed 21421661
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS- Form
Liquid
- Clonality
Polyclonal
Immunogen
- Synthetic Peptide within Human OVGP1. The exact immunogen used to generate this antibody is proprietary information. Database link Q12889
Reactivity data
Select an application| WB | ICC/IF | |
|---|---|---|
| Human | Tested | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1 µg/mL | Notes - |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 20 µg/mL | Notes - |
Associated Products
Select an associated product type
1 product for Alternative Product
Target data
Function
Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development.
Alternative names
MUC9, OGP, OGP, MUC9, OVGP1, Oviduct-specific glycoprotein, Estrogen-dependent oviduct protein, Mucin-9, Oviductal glycoprotein, Oviductin
Recommended products
Rabbit Polyclonal OVGP1/OGP antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human OVGP1.
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS- Form
Liquid
- Clonality
Polyclonal
- Immunogen
- Synthetic Peptide within Human OVGP1. The exact immunogen used to generate this antibody is proprietary information. Database link Q12889
- Purification technique
Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
+4°C
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
OVGP1 also known as oviductal glycoprotein or OGP is a glycoprotein with a molecular mass around 120 kDa. This protein is expressed mainly in the oviduct epithelium in mammals. It is secreted during the peri-ovulatory phase and associates with the zona pellucida and the oocyte. OGP products are studied extensively due to their role in reproductive biology especially concerning fertilization and early embryonic development.
- Biological function summary
OVGP1 plays an important role in reproduction. It interacts with the zona pellucida and helps facilitate sperm binding and penetration enhancing fertilization potential. The protein is not part of a large complex but is known for modifying the environment in the oviduct to support fertility. It also maintains the stability and permeability of the oocyte and embryo matrix impacting early stages of embryo development.
- Pathways
OVGP1 influences reproductive pathways that involve sperm-egg interaction and embryo transport. The glycoprotein acts along pathways connected to fertilization affecting the zona pellucida's structural and functional properties which are also influenced by proteins like ZP3 (zona pellucida glycoprotein 3). These pathways ensure that the conditions in the oviduct are optimal for successful conception and embryo support.
- Associated diseases and disorders
OVGP1 has been linked to infertility and reproductive challenges. Altered expression or dysfunction of this protein can affect fertility contributing to conditions like fallopian tube disorders and ectopic pregnancies. It might also interact with other proteins related to infertility such as inhibin affecting its pathways and mechanisms. Understanding these interactions provides insight into the treatment and management of reproductive health issues.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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3 product images
Immunocytochemistry/ Immunofluorescence - Anti-OVGP1/OGP antibody (ab74544)
PFA-fixed, Triton X-100 permeabilized HEK-293 (human epithelial cell line from embryonic kidney) cells stained for OVGP1/OGP (green) using ab74544 at 5 μg/ml in ICC/IF.
Western blot - Anti-OVGP1/OGP antibody (ab74544)
All lanes: Western blot - Anti-OVGP1/OGP antibody (ab74544) at 1 µg/mL
All lanes: human placenta tissue lysate
Predicted band size: 75 kDa
Observed band size: 150 kDa
Immunocytochemistry/ Immunofluorescence - Anti-OVGP1/OGP antibody (ab74544)
PFA-fixed, Triton X-100 permeabilized HEK-293 (human epithelial cell line from embryonic kidney) cells stained for OVGP1/OGP using ab74544 at 2.5 μg/ml in ICC/IF.
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