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Mouse Monoclonal OVOL1 antibody. Suitable for WB and reacts with Recombinant fragment - Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Putative transcription factor Ovo-like 1.

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Images

Western blot - Anti-OVOL1 antibody [460C1a] (AB74520), expandable thumbnail

Publications

Key facts

Isotype

IgG1

Host species

Mouse

Storage buffer

pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: PBS, 1% BSA

Form

Liquid

Clonality

Monoclonal

Immunogen

  • Recombinant Fragment Protein within Human Putative transcription factor Ovo-like 1. The exact immunogen used to generate this antibody is proprietary information. Database link O14753

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WB
Recombinant fragment - Human
Tested

Tested
Tested

Species

Recombinant fragment - Human

Dilution info

-

Notes

-

Associated Products

Select an associated product type

2 products for Alternative Product

Target data

Function

Putative transcription factor. Involved in hair formation and spermatogenesis. May function in the differentiation and/or maintenance of the urogenital system (By similarity).

Alternative names

Recommended products

Mouse Monoclonal OVOL1 antibody. Suitable for WB and reacts with Recombinant fragment - Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Putative transcription factor Ovo-like 1.

Key facts

Isotype

IgG1

Form

Liquid

Clonality

Monoclonal

Immunogen
  • Recombinant Fragment Protein within Human Putative transcription factor Ovo-like 1. The exact immunogen used to generate this antibody is proprietary information. Database link O14753
Clone number

460C1a

Purification technique

Affinity purification Protein G

Concentration
Loading...
Purification notes

ab74520 was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum and then filtered through a 0.22µm membrane.

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

OVOL1 also known as Ovo1 or VOV1 is a zinc finger transcription factor with a molecular weight of approximately 33 kDa. It plays an essential role in regulating gene expression during development and differentiation. OVOL1 is expressed primarily in epithelial tissues including skin kidney and testis. It functions by binding to specific DNA sequences and altering the transcriptional activity of target genes involved in growth and maturation processes.

Biological function summary

OVOL1 acts as a regulator of epithelial cell fate and morphogenesis. It influences proliferation differentiation and apoptosis facilitating normal tissue homeostasis and development. OVOL1 does not form a complex with other proteins but acts as a node in controlling transcription factors. Its function is tightly controlled by various signaling pathways which orchestrate the balance between cell growth and differentiation. OVOL1's role emphasizes its importance in epithelial tissue development and repair.

Pathways

The regulation of OVOL1 integrates into the Wnt/β-catenin and BMP signaling pathways. These pathways are important for cell fate determination and tissue patterning during development. OVOL1 modulates the activity of related proteins like c-Myc and LEF1 providing a connection between transcriptional regulation and signal transduction. It acts as a gatekeeper ensuring cells follow appropriate developmental cues within the overall signaling network.

Associated diseases and disorders

Mutations and dysregulation of OVOL1 have been implicated in hair loss disorders and certain cancers including bladder and colorectal cancers. Altered expression of OVOL1 can lead to disrupted epithelial cell differentiation contributing to pathologies characterized by abnormal cell proliferation and invasion. In particular OVOL1's interaction with proteins like β-catenin and TCF4 highlights its involvement in oncogenic pathways that drive cancer progression.

Product promise

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1 product image

  • Western blot - Anti-OVOL1 antibody [460C1a] (ab74520), expandable thumbnail

    Western blot - Anti-OVOL1 antibody [460C1a] (ab74520)

    The molecular weight of the band on the western blot does not correspond to the molecular weight of the natural protein because only a fragment of the protein was used.

    All lanes: Western blot - Anti-OVOL1 antibody [460C1a] (ab74520)

    All lanes: Immunising recombinant peptide

    Predicted band size: 30 kDa

    Observed band size: 37 kDa

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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