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AB74520

Anti-OVOL1 antibody [460C1a]

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(2 Publications)

Mouse Monoclonal OVOL1 antibody. Suitable for WB and reacts with Recombinant fragment - Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Putative transcription factor Ovo-like 1.

View Alternative Names

Putative transcription factor Ovo-like 1, hOvo1, OVOL1

1 Images
Western blot - Anti-OVOL1 antibody [460C1a] (AB74520)
  • WB

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Western blot - Anti-OVOL1 antibody [460C1a] (AB74520)

The molecular weight of the band on the western blot does not correspond to the molecular weight of the natural protein because only a fragment of the protein was used.

All lanes:

Western blot - Anti-OVOL1 antibody [460C1a] (ab74520)

All lanes:

Immunising recombinant peptide

Predicted band size: 30 kDa

Observed band size: 37 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

460C1a

Isotype

IgG1

Carrier free

No

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human Putative transcription factor Ovo-like 1. The exact immunogen used to generate this antibody is proprietary information.

O14753

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
ab74520 was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum and then filtered through a 0.22µm membrane.
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

OVOL1 also known as Ovo1 or VOV1 is a zinc finger transcription factor with a molecular weight of approximately 33 kDa. It plays an essential role in regulating gene expression during development and differentiation. OVOL1 is expressed primarily in epithelial tissues including skin kidney and testis. It functions by binding to specific DNA sequences and altering the transcriptional activity of target genes involved in growth and maturation processes.
Biological function summary

OVOL1 acts as a regulator of epithelial cell fate and morphogenesis. It influences proliferation differentiation and apoptosis facilitating normal tissue homeostasis and development. OVOL1 does not form a complex with other proteins but acts as a node in controlling transcription factors. Its function is tightly controlled by various signaling pathways which orchestrate the balance between cell growth and differentiation. OVOL1's role emphasizes its importance in epithelial tissue development and repair.

Pathways

The regulation of OVOL1 integrates into the Wnt/β-catenin and BMP signaling pathways. These pathways are important for cell fate determination and tissue patterning during development. OVOL1 modulates the activity of related proteins like c-Myc and LEF1 providing a connection between transcriptional regulation and signal transduction. It acts as a gatekeeper ensuring cells follow appropriate developmental cues within the overall signaling network.

Mutations and dysregulation of OVOL1 have been implicated in hair loss disorders and certain cancers including bladder and colorectal cancers. Altered expression of OVOL1 can lead to disrupted epithelial cell differentiation contributing to pathologies characterized by abnormal cell proliferation and invasion. In particular OVOL1's interaction with proteins like β-catenin and TCF4 highlights its involvement in oncogenic pathways that drive cancer progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Putative transcription factor. Involved in hair formation and spermatogenesis. May function in the differentiation and/or maintenance of the urogenital system (By similarity).
See full target information Putative transcription factor Ovo-like 1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of clinical medicine 9: PubMed32106476

2020

OVOL2-Mediated ZEB1 Downregulation May Prevent Promotion of Actinic Keratosis to Cutaneous Squamous Cell Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Maho Murata,Takamichi Ito,Yuka Tanaka,Kazuhiko Yamamura,Kazuhisa Furue,Masutaka Furue

Cell death & disease 8:e2931 PubMed28703805

2017

Aryl hydrocarbon receptor activation restores filaggrin expression via OVOL1 in atopic dermatitis.

Applications

Unspecified application

Species

Unspecified reactive species

Gaku Tsuji,Akiko Hashimoto-Hachiya,Mari Kiyomatsu-Oda,Masaki Takemura,Fumitaka Ohno,Takamichi Ito,Saori Morino-Koga,Chikage Mitoma,Takeshi Nakahara,Hiroshi Uchi,Masutaka Furue
View all publications
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Product promise

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