Mouse Monoclonal OVOL1 antibody. Suitable for WB and reacts with Recombinant fragment - Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Putative transcription factor Ovo-like 1.
IgG1
Mouse
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: PBS, 1% BSA
Liquid
Monoclonal
WB | |
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Recombinant fragment - Human | Tested |
Species | Dilution info | Notes |
---|---|---|
Species Recombinant fragment - Human | Dilution info - | Notes - |
Select an associated product type
Putative transcription factor. Involved in hair formation and spermatogenesis. May function in the differentiation and/or maintenance of the urogenital system (By similarity).
Putative transcription factor Ovo-like 1, hOvo1, OVOL1
Mouse Monoclonal OVOL1 antibody. Suitable for WB and reacts with Recombinant fragment - Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Putative transcription factor Ovo-like 1.
IgG1
Mouse
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: PBS, 1% BSA
Liquid
Monoclonal
460C1a
Affinity purification Protein G
ab74520 was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum and then filtered through a 0.22µm membrane.
Blue Ice
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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This supplementary information is collated from multiple sources and compiled automatically.
OVOL1 also known as Ovo1 or VOV1 is a zinc finger transcription factor with a molecular weight of approximately 33 kDa. It plays an essential role in regulating gene expression during development and differentiation. OVOL1 is expressed primarily in epithelial tissues including skin kidney and testis. It functions by binding to specific DNA sequences and altering the transcriptional activity of target genes involved in growth and maturation processes.
OVOL1 acts as a regulator of epithelial cell fate and morphogenesis. It influences proliferation differentiation and apoptosis facilitating normal tissue homeostasis and development. OVOL1 does not form a complex with other proteins but acts as a node in controlling transcription factors. Its function is tightly controlled by various signaling pathways which orchestrate the balance between cell growth and differentiation. OVOL1's role emphasizes its importance in epithelial tissue development and repair.
The regulation of OVOL1 integrates into the Wnt/β-catenin and BMP signaling pathways. These pathways are important for cell fate determination and tissue patterning during development. OVOL1 modulates the activity of related proteins like c-Myc and LEF1 providing a connection between transcriptional regulation and signal transduction. It acts as a gatekeeper ensuring cells follow appropriate developmental cues within the overall signaling network.
Mutations and dysregulation of OVOL1 have been implicated in hair loss disorders and certain cancers including bladder and colorectal cancers. Altered expression of OVOL1 can lead to disrupted epithelial cell differentiation contributing to pathologies characterized by abnormal cell proliferation and invasion. In particular OVOL1's interaction with proteins like β-catenin and TCF4 highlights its involvement in oncogenic pathways that drive cancer progression.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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Terms & Conditions.
The molecular weight of the band on the western blot does not correspond to the molecular weight of the natural protein because only a fragment of the protein was used.
All lanes: Western blot - Anti-OVOL1 antibody [460C1a] (ab74520)
All lanes: Immunising recombinant peptide
Predicted band size: 30 kDa
Observed band size: 37 kDa
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