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AB235949

Anti-OVOL1 antibody

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(2 Publications)

Rabbit Polyclonal OVOL1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Putative transcription factor Ovo-like 1 aa 1 to C-terminus.

View Alternative Names

Putative transcription factor Ovo-like 1, hOvo1, OVOL1

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OVOL1 antibody (AB235949)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OVOL1 antibody (AB235949)

Paraffin-embedded human kidney tissue stained for OVOL1 using ab235949 at 1/100 dilution in immunohistochemical analysis.

Western blot - Anti-OVOL1 antibody (AB235949)
  • WB

Supplier Data

Western blot - Anti-OVOL1 antibody (AB235949)

All lanes:

Western blot - Anti-OVOL1 antibody (ab235949) at 1/1000 dilution

All lanes:

K562 (human chronic myelogenous leukemia cell line from bone marrow) whole cell lysate

Secondary

All lanes:

Goat polyclonal to rabbit at 1/10000 dilution

Predicted band size: 30 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human Putative transcription factor Ovo-like 1 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O14753

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

OVOL1 also known as Ovo1 or VOV1 is a zinc finger transcription factor with a molecular weight of approximately 33 kDa. It plays an essential role in regulating gene expression during development and differentiation. OVOL1 is expressed primarily in epithelial tissues including skin kidney and testis. It functions by binding to specific DNA sequences and altering the transcriptional activity of target genes involved in growth and maturation processes.
Biological function summary

OVOL1 acts as a regulator of epithelial cell fate and morphogenesis. It influences proliferation differentiation and apoptosis facilitating normal tissue homeostasis and development. OVOL1 does not form a complex with other proteins but acts as a node in controlling transcription factors. Its function is tightly controlled by various signaling pathways which orchestrate the balance between cell growth and differentiation. OVOL1's role emphasizes its importance in epithelial tissue development and repair.

Pathways

The regulation of OVOL1 integrates into the Wnt/β-catenin and BMP signaling pathways. These pathways are important for cell fate determination and tissue patterning during development. OVOL1 modulates the activity of related proteins like c-Myc and LEF1 providing a connection between transcriptional regulation and signal transduction. It acts as a gatekeeper ensuring cells follow appropriate developmental cues within the overall signaling network.

Mutations and dysregulation of OVOL1 have been implicated in hair loss disorders and certain cancers including bladder and colorectal cancers. Altered expression of OVOL1 can lead to disrupted epithelial cell differentiation contributing to pathologies characterized by abnormal cell proliferation and invasion. In particular OVOL1's interaction with proteins like β-catenin and TCF4 highlights its involvement in oncogenic pathways that drive cancer progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Putative transcription factor. Involved in hair formation and spermatogenesis. May function in the differentiation and/or maintenance of the urogenital system (By similarity).
See full target information Putative transcription factor Ovo-like 1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:27417 PubMed40721855

2025

Unveiling the impact of OVOL1 on prognosis, immune microenvironment, and proliferation in pancreatic cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Jinping Li,Zhenyan Deng,Zhaofang Yan,Shuxian Huang,Jiamin Jin,Chichu Xie,Jinfeng Gan

Cell cycle (Georgetown, Tex.) 19:3277-3288 PubMed33121324

2020

Long noncoding RNA MEG3 suppresses cell proliferation, migration and invasion, induces apoptosis and paclitaxel-resistance via miR-4513/PBLD axis in breast cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Mingzhi Zhu,Fang Wang,Hailong Mi,Lin Li,Jing Wang,Mingli Han,Yuanting Gu
View all publications
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