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AB169469

Anti-OVOL2 antibody

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(4 Publications)

Mouse Polyclonal OVOL2 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human OVOL2.

View Alternative Names

ZNF339, OVOL2, Transcription factor Ovo-like 2, hOvo2, Zinc finger protein 339

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-OVOL2 antibody (AB169469)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-OVOL2 antibody (AB169469)

Immunofluorescent analysis of HeLa cells labeling OVOL2 with ab169469 at 10 µg/ml.

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Full Length Protein corresponding to Human OVOL2.

Q9BRP0

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

OVOL2 also known as Ovo-like zinc finger 2 is a transcription factor with a molecular weight of approximately 32 kDa. It plays a mechanical role in regulating gene expression by binding to specific DNA sequences. OVOL2 is expressed in various tissues most notably in the skin and hair follicles as well as epithelial tissues. Its function is connected to development processes such as differentiation and proliferation.
Biological function summary

OVOL2 influences epithelial-mesenchymal transition (EMT) which is important for embryogenesis and wound healing. It often interacts with other factors to stabilize epithelial cell identity. OVOL2 does not function alone; it forms a part of a network of transcription factors allowing it to modulate a wide range of downstream effects. This integrated action reflects its importance in maintaining the balance between cell states for example during development.

Pathways

The protein is essential in the Wnt signaling pathway and the TGF-beta pathway. These pathways play an integral role in controlling cell growth differentiation and migration. OVOL2 interacts with other proteins like beta-catenin and Smad proteins within these pathways. This interaction ensures precise control over cellular behavior and responses thereby influencing actively the development and progression of cells.

OVOL2 is relevant to cancer development particularly in breast and prostate cancers. The protein's activity can influence tumor progression due to its role in EMT and regulation of cell proliferation. It is connected to other proteins such as E-cadherin and Snail which are involved in cancer progression. Dysregulation of OVOL2 can lead to aberrant cell behavior and contribute to the oncogenic process.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Zinc-finger transcription repressor factor (PubMed : 19700410). Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer (By similarity). Positively regulates neuronal differentiation (By similarity). Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1 (PubMed : 19700410). Important for the correct development of primordial germ cells in embryos (By similarity). Plays dual functions in thermogenesis and adipogenesis to maintain energy balance. Essential for brown/beige adipose tissue-mediated thermogenesis, is necessary for the development of brown adipocytes. In white adipose tissues, limits adipogenesis by blocking CEBPA binding to its transcriptional targets and inhibiting its transcription factor activity (By similarity).
See full target information OVOL2
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

EMBO molecular medicine 15:e17836 PubMed37766669

2023

Propionate reinforces epithelial identity and reduces aggressiveness of lung carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Vignesh Ramesh,Paradesi Naidu Gollavilli,Luisa Pinna,Mohammad Aarif Siddiqui,Adriana Martinez Turtos,Francesca Napoli,Yasmin Antonelli,Aldo Leal-Egaña,Jesper Foged Havelund,Simon Toftholm Jakobsen,Elisa Le Boiteux,Marco Volante,Nils Joakim Faergeman,Ole N Jensen,Rasmus Siersbaek,Kumar Somyajit,Paolo Ceppi

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 9:e2200705 PubMed35896951

2022

Transcriptional Repression of Aerobic Glycolysis by OVOL2 in Breast Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Xiujuan Zhang,Fei Luo,Shaliu Luo,Ling Li,Xinxin Ren,Jing Lin,Yingchun Liang,Chao Ma,Lihua Ding,Deyu Zhang,Tianxing Ye,Yanni Lin,Bilian Jin,Shan Gao,Qinong Ye

Cell biology international 46:1409-1422 PubMed35842772

2022

LMCD1 facilitates the induction of pluripotency via cell proliferation, metabolism, and epithelial-mesenchymal transition.

Applications

Unspecified application

Species

Unspecified reactive species

Zhikai Ye,Ge Chen,Cuicui Hou,Zhenlong Jiang,Erkang Wang,Jin Wang

Journal of cellular biochemistry : PubMed30417553

2018

Long noncoding RNA MEG3 inhibits proliferation and migration but induces autophagy by regulation of Sirt7 and PI3K/AKT/mTOR pathway in glioma cells.

Applications

Unspecified application

Species

Unspecified reactive species

Dong-Hui Xu,Guo-Nan Chi,Cong-Hai Zhao,Dong-Yuan Li
View all publications
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Product promise

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