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AB88975

Anti-OXA1L antibody

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(3 Publications)

Mouse Polyclonal OXA1L antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Mitochondrial inner membrane protein OXA1L.

View Alternative Names

Mitochondrial inner membrane protein OXA1L, OXA1Hs, Oxidase assembly 1-like protein, OXA1-like protein, OXA1L

2 Images
Western blot - Anti-OXA1L antibody (AB88975)
  • WB

Unknown

Western blot - Anti-OXA1L antibody (AB88975)

All lanes:

Western blot - Anti-OXA1L antibody (ab88975) at 1/500 dilution

All lanes:

Human liver lysate at 50 µg

Predicted band size: 49 kDa

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Western blot - Anti-OXA1L antibody (AB88975)
  • WB

Unknown

Western blot - Anti-OXA1L antibody (AB88975)

All lanes:

Western blot - Anti-OXA1L antibody (ab88975) at 1/500 dilution

Lane 1:

OXA1L-transfected 293T cell lysate at 25 µg

Lane 2:

non transfected lysate at 25 µg

Predicted band size: 49 kDa

Observed band size: 48 kDa

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Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human Mitochondrial inner membrane protein OXA1L.

Q15070

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

OXA1L also known as mitochondrial inner membrane protein OXA1L functions mechanically in the insertion and assembly of proteins in the mitochondrial inner membrane. This protein with a mass of approximately 45 kDa localizes to the mitochondria and exhibits broad tissue expression. OXA1L plays a role in protein translocation specifically contributing to the insertion of multi-spanning membrane proteins coming from the mitochondrial ribosomes.
Biological function summary

OXA1L facilitates the integration of proteins into the mitochondrial inner membrane essential for maintaining mitochondrial function and biogenesis. OXA1L operates as part of a larger complex that assists protein assembly and stabilization. Such interactions highlight its role in mitochondrial respiratory chain assembly necessary for maintaining cellular energy balance.

Pathways

OXA1L integrates specifically into the pathway of mitochondrial oxidative phosphorylation. This target works alongside important proteins like COX1 and COX2 shaping the proper assembly of components of the electron transport chain. Additionally OXA1L interacts with the mitochondrial import machinery vital for maintaining the efficiency of protein import pathways that regulate cellular respiration.

Mutations or dysregulation of OXA1L correlate with mitochondrial disorders and neurological diseases including sensorineural hearing loss and mitochondrial complex I deficiency. NDUFAF2 involved in complex I assembly shows interaction with OXA1L in these conditions highlighting a shared pathway that can lead to disrupted energy production and neurological symptoms.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Mitochondrial membrane insertase that mediates the cotranslational insertion of integral membrane proteins into the mitochondrial inner membrane (PubMed : 17936786, PubMed : 33602856, PubMed : 7991568). Essential for the activity and assembly of cytochrome oxidase (PubMed : 17936786, PubMed : 7991568). Required for the correct biogenesis of ATP synthase and complex I in mitochondria (PubMed : 17936786, PubMed : 7991568).
See full target information Mitochondrial inner membrane protein OXA1L
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Biochemical pharmacology 218:115925 PubMed37981173

2023

A novel gene signature to diagnose MASLD in metabolically unhealthy obese individuals.

Applications

Unspecified application

Species

Unspecified reactive species

Marica Meroni,Federica Chiappori,Erika Paolini,Miriam Longo,Emilia De Caro,Ettore Mosca,Alice Chiodi,Ivan Merelli,Sara Badiali,Marco Maggioni,Alessandra Mezzelani,Luca Valenti,Anna Ludovica Fracanzani,Paola Dongiovanni

Bio-protocol 11:e4110 PubMed34458404

2021

Purification of Mitochondrial Ribosomes with the Translocase Oxa1L from HEK Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Hanting Yang,Nirupa Desai

The Journal of neuroscience : the official journal of the Society for Neuroscience 31:16369-86 PubMed22072688

2011

Quantitative and integrative proteome analysis of peripheral nerve myelin identifies novel myelin proteins and candidate neuropathy loci.

Applications

Unspecified application

Species

Unspecified reactive species

Julia Patzig,Olaf Jahn,Stefan Tenzer,Sven P Wichert,Patricia de Monasterio-Schrader,Susanne Rosfa,Jörg Kuharev,Kuo Yan,Ingo Bormuth,Juliane Bremer,Adriano Aguzzi,Foteini Orfaniotou,Dörte Hesse,Markus H Schwab,Wiebke Möbius,Klaus-Armin Nave,Hauke Bernhard Werner
View all publications
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Product promise

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