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AB67351

Anti-OXGR1/GPR99 antibody

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(1 Publication)

Rabbit Polyclonal OXGR1/GPR99 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human OXGR1 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

GPR80, GPR99, P2RY15, P2Y15, OXGR1, 2-oxoglutarate receptor 1, Alpha-ketoglutarate receptor 1, G-protein coupled receptor 80, G-protein coupled receptor 99, P2Y purinoceptor 15, P2Y-like GPCR, P2Y-like nucleotide receptor

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OXGR1/GPR99 antibody (AB67351)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OXGR1/GPR99 antibody (AB67351)

ab67351 at 20μg/ml staining OXGR1/GPR99 in human kidney by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human OXGR1 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q96P68

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "20 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

OXGR1 also known as GPR99 is a G protein-coupled receptor with a molecular mass of approximately 40 kDa. This receptor is expressed in various tissues including the kidney placenta liver and brain. It functions as a receptor for alpha-ketoglutarate playing a role in cellular signaling. The activation of OXGR1 influences cellular responses by interacting with intracellular G proteins initiating signaling cascades that modulate biological processes.
Biological function summary

OXGR1 plays roles in the regulation of renal function and blood pressure homeostasis. It is not part of a larger protein complex but interacts with intracellular signaling molecules. Through its affinity for alpha-ketoglutarate OXGR1 participates in energy metabolism and cellular response to changes in metabolic conditions. Its expression and activity influence how cells adapt to fluctuating energy demands by modulating signal transduction pathways.

Pathways

Research shows that OXGR1 integrates into the tricarboxylic acid (TCA) cycle and might engage in signaling pathways including the renin-angiotensin system. It may influence blood pressure and fluid balance through this system. OXGR1 also shares pathways with other G protein-coupled receptors such as angiotensin II receptor type 1 which further implicates its role in maintaining cardiovascular stability and energy homeostasis.

Studies link OXGR1 to hypertension and chronic kidney disease. Dysfunction in its signaling can contribute to abnormalities in blood pressure regulation and kidney function. It is connected to proteins like angiotensin-converting enzyme which play roles in cardiovascular diseases. Understanding OXGR1's function and involvement in these contexts can help develop therapeutic strategies aimed at modulating its activity for disease management.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor for alpha-ketoglutarate. Seems to act exclusively through a G(q)-mediated pathway.
See full target information OXGR1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of clinical investigation 123:3166-71 PubMed23934124

2013

α-Ketoglutarate regulates acid-base balance through an intrarenal paracrine mechanism.

Applications

Unspecified application

Species

Unspecified reactive species

Natsuko Tokonami,Luciana Morla,Gabriel Centeno,David Mordasini,Suresh Krishna Ramakrishnan,Svetlana Nikolaeva,Carsten A Wagner,Olivier Bonny,Pascal Houillier,Alain Doucet,Dmitri Firsov
View all publications
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Product promise

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