AB251774

Anti-OXR1 antibody

Name: Anti-OXR1 antibody (ab251774) | Abcam
Brand: Abcam Limited
SKU: AB251774
Price: 655 USD
Availability: InStock

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(3 Publications)

Rabbit Polyclonal OXR1 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human OXR1 aa 250 to C-terminus.

View Alternative Names

Nbla00307, OXR1, Oxidation resistance protein 1

6 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OXR1 antibody (AB251774)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OXR1 antibody (AB251774)

Formalin-fixed, paraffin-embedded human cerebral cortex tissue stained for OXR1 with ab251774 at a 1/50 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OXR1 antibody (AB251774)

Formalin-fixed, paraffin-embedded human testis tissue stained for OXR1 with ab251774 at a 1/50 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OXR1 antibody (AB251774)

Formalin-fixed, paraffin-embedded human Fallopian tube tissue stained for OXR1 with ab251774 at a 1/50 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-OXR1 antibody (AB251774)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-OXR1 antibody (AB251774)

PFA-fixed, Triton X-100 permeabilized A431 (human epidermoid carcinoma cell line) cells stained for OXR1 (green) using ab251774 at 4 µg/ml in ICC/IF.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OXR1 antibody (AB251774)

Formalin-fixed, paraffin-embedded human pancreas tissue stained for OXR1 with ab251774 at a 1/50 dilution in immunohistochemical analysis.

Unknown

Western blot - Anti-OXR1 antibody (AB251774)

All lanes:

Western blot - Anti-OXR1 antibody (ab251774) at 0.4 µg/mL

Lane 1:

Vector only transfected HEK-293T (Human epithelial cell line from embryonic kidney transformed with large T antigen) lysate

Lane 2:

OXR1 overexpression HEK-293T cell lysate

Predicted band size: 98 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human OXR1 aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q8N573

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": " Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "Fixation/Permeabilization: PFA/Triton X-100." }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

OXR1 also known as Oxidation Resistance 1 is a protein that plays a significant role in cellular defense against oxidative stress. It has a mass of approximately 87 kDa. OXR1 is widely expressed in human tissues with higher levels observed in the brain and liver. This protein localizes primarily in the mitochondria where it contributes to safeguarding cells by being part of the antioxidant defense system.

Biological function summary

OXR1 mitigates oxidative damage and enhances cell survival under stress conditions. It stimulates the expression of antioxidant enzymes including superoxide dismutase and catalase. OXR1 doesn't act alone but functions as part of a protective network to maintain cellular redox balance. Its role is important in neural tissues where oxidative stress can lead to severe damage.

Pathways

OXR1 engages in oxidative stress and mitochondrial homeostasis pathways. Its activity is linked to the antioxidant response elements and interacts with proteins like Nrf2 (Nuclear factor erythroid 2-related factor 2) which orchestrates the regulation of antioxidant proteins. By participating in these pathways OXR1 helps to modulate cellular responses to oxidative insults and contributes to maintaining cellular integrity.

OXR1 has been associated with neurodegenerative diseases like amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease. Altered function or expression of OXR1 can lead to increased oxidative damage exacerbating these conditions. OXR1's interaction with proteins such as Nrf2 indicates a connection to pathways that when dysregulated contribute to disease processes. Understanding the role of OXR1 in these disorders could offer insights into novel therapeutic strategies aimed at reducing oxidative damage.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

May be involved in protection from oxidative damage.

See full target information OXR1

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Cell death discovery 11:192 PubMed40263288

2025

QKI-induced circ_0001766 inhibits colorectal cancer progression and rapamycin resistance by miR-1203/PPP1R3C/mTOR/Myc axis.

Applications

Unspecified application

Species

Unspecified reactive species

Yulai Zhou,Yan Gao,Yinghui Peng,Changjing Cai,Ying Han,Yihong Chen,Gongping Deng,Yanhong Ouyang,Hong Shen,Shan Zeng,Yangfeng Du,Zemin Xiao

Cell 186:5411-5427.e23 PubMed37918396

2023

The proteomic landscape of synaptic diversity across brain regions and cell types.

Applications

Unspecified application

Species

Unspecified reactive species

Marc van Oostrum,Thomas M Blok,Stefano L Giandomenico,Susanne Tom Dieck,Georgi Tushev,Nicole Fürst,Julian D Langer,Erin M Schuman

Annals of translational medicine 10:928 PubMed36172098

2022

MicroRNA-668-3p regulates oxidative stress and cell damage induced by Aβ1-42 by targeting the /p53-p21 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Shengyu Li,Lishuo Wu,Meigang Ma,Longxiu Yang,Chao Qin

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-OXR1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OXR1 antibody (AB251774)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OXR1 antibody (AB251774)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OXR1 antibody (AB251774)

Immunocytochemistry/ Immunofluorescence - Anti-OXR1 antibody (AB251774)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OXR1 antibody (AB251774)

Western blot - Anti-OXR1 antibody (AB251774)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Complementary Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

Product promise