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AB227511

Anti-OXR1 antibody - C-terminal

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(1 Publication)

Rabbit Polyclonal OXR1 antibody. C-terminal. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human OXR1.

View Alternative Names

Nbla00307, OXR1, Oxidation resistance protein 1

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OXR1 antibody - C-terminal (AB227511)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OXR1 antibody - C-terminal (AB227511)

Paraffin-embedded human gastric cancer tissue stained for OXR1 with ab227511 at 1/500 dilution in immunohistochemical analysis.

Western blot - Anti-OXR1 antibody - C-terminal (AB227511)
  • WB

Supplier Data

Western blot - Anti-OXR1 antibody - C-terminal (AB227511)

7.5% SDS-PAGE gel.

All lanes:

Western blot - Anti-OXR1 antibody - C-terminal (ab227511) at 1/1000 dilution

All lanes:

IMR32 (human brain neuroblast cell line) whole cell lysate at 30 µg

Predicted band size: 58 kDa,68 kDa,98 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human OXR1. The exact immunogen used to generate this antibody is proprietary information.

Q8N573

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

OXR1 also known as Oxidation Resistance 1 is a protein that plays a significant role in cellular defense against oxidative stress. It has a mass of approximately 87 kDa. OXR1 is widely expressed in human tissues with higher levels observed in the brain and liver. This protein localizes primarily in the mitochondria where it contributes to safeguarding cells by being part of the antioxidant defense system.
Biological function summary

OXR1 mitigates oxidative damage and enhances cell survival under stress conditions. It stimulates the expression of antioxidant enzymes including superoxide dismutase and catalase. OXR1 doesn't act alone but functions as part of a protective network to maintain cellular redox balance. Its role is important in neural tissues where oxidative stress can lead to severe damage.

Pathways

OXR1 engages in oxidative stress and mitochondrial homeostasis pathways. Its activity is linked to the antioxidant response elements and interacts with proteins like Nrf2 (Nuclear factor erythroid 2-related factor 2) which orchestrates the regulation of antioxidant proteins. By participating in these pathways OXR1 helps to modulate cellular responses to oxidative insults and contributes to maintaining cellular integrity.

OXR1 has been associated with neurodegenerative diseases like amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease. Altered function or expression of OXR1 can lead to increased oxidative damage exacerbating these conditions. OXR1's interaction with proteins such as Nrf2 indicates a connection to pathways that when dysregulated contribute to disease processes. Understanding the role of OXR1 in these disorders could offer insights into novel therapeutic strategies aimed at reducing oxidative damage.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May be involved in protection from oxidative damage.
See full target information OXR1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

iScience 28:113041 PubMed40822354

2025

Cholinotrophic basal forebrain connectome dysfunction in Down syndrome with and without dementia.

Applications

Unspecified application

Species

Unspecified reactive species

Marta Moreno-Rodriguez,Sylvia E Perez,Muhammad Nadeem,Elizabeth Head,Elliott J Mufson
View all publications
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Product promise

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