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AB124771

Anti-Oxytocin-neurophysin 1 antibody [EPR4665]

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(1 Publication)

Rabbit Recombinant Monoclonal Oxytocin-neurophysin 1 antibody. Suitable for ELISA and reacts with Synthetic peptide - Human samples. Cited in 1 publication.

View Alternative Names

OT, OXT, Oxytocin-neurophysin 1, OT-NPI, MGC126890, MGC126892, Neurophysin 1, Neurophysin I, OT, OT NPI, OXT, Ocytocin, Oxytocin Neurophysin preproprotein, Oxytocin prepro (neurophysin I), Oxytocin prepropeptide

1 Images
ELISA - Anti-Oxytocin-neurophysin 1 antibody [EPR4665] (AB124771)
  • ELISA

Unknown

ELISA - Anti-Oxytocin-neurophysin 1 antibody [EPR4665] (AB124771)

ELISA image demonstrating the relationship between the concentration of antibody and optical density readings.

  • Carrier free

    Anti-Oxytocin-neurophysin 1 antibody [EPR4665] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR4665

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ELISA

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Alternative Products

Primary Antibodies

AB228508

Anti-Oxytocin-neurophysin 1 antibody

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Complementary Products

Assay Kits

AB242248

Human Oxytocin-neurophysin 1 Prepropeptide ELISA Kit

Recombinant|SimpleStep

ELISA - Human Oxytocin-neurophysin 1 Prepropeptide ELISA Kit (AB242248)

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Primary Antibodies

AB300443

Anti-Oxytocin Receptor antibody [EPR24409-146]

20ul selling size|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Oxytocin Receptor antibody [EPR24409-146] (AB300443)

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Assay Kits

AB242248

Human Oxytocin-neurophysin 1 Prepropeptide ELISA Kit

Recombinant|SimpleStep

ELISA - Human Oxytocin-neurophysin 1 Prepropeptide ELISA Kit (AB242248)

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Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

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Primary Antibodies

AB213708

Anti-Vasopressin antibody [EPR20602]

RabMAb|Recombinant|20ul selling size

Flow Cytometry (Intracellular) - Anti-Vasopressin antibody [EPR20602] (AB213708)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "predicted", "ELISA-species-dilution-info": "", "ELISA-species-notes": "" }, "Synthetic peptide - Human": { "ELISA-species-checked": "testedAndGuaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>" } } }
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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Stable for 12 months at -20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Oxytocin-neurophysin 1 also known as prepro-oxytocin-neurophysin I is a precursor protein with a molecular weight of approximately 20 kDa. This protein is expressed primarily in the hypothalamus and is involved in the synthesis and storage of the hormone oxytocin a peptide essential for various physiological processes. During synthesis the protein undergoes cleavage to separate oxytocin and neurophysin 1 a carrier protein that aids in the transport and stabilization of oxytocin in neurosecretory granules.
Biological function summary

Oxytocin-neurophysin 1 plays an important role in the regulation of social behaviors reproductive functions and fluid homeostasis. This precursor is not part of a larger protein complex but neurophysin 1 serves as an essential carrier that binds and transports oxytocin to its target sites in the body. Oxytocin itself functions as a neuromodulator and hormone exerting effects on the uterine muscles and mammary glands promoting childbirth and lactation.

Pathways

The biosynthesis and release of oxytocin-neurophysin 1 are closely associated with the hypothalamic neurosecretory pathways. These pathways involve the neurohypophysis where oxytocin is released into the bloodstream. Additionally oxytocin interacts with the G-protein-coupled receptor OXTR to elicit its physiological effects. V1a and V2 receptors alongside oxytocin play roles in various signaling pathways that affect metabolic and cardiovascular functions.

Dysregulation of oxytocin-neurophysin 1 has been linked to the syndrome of inappropriate antidiuretic hormone secretion (SIADH) and autism spectrum disorders. In these conditions altered levels of oxytocin affect fluid balance and social behavior. Additionally changes in oxytocin levels often in tandem with altered vasopressin regulation associate with the development and exacerbation of these disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Neurophysin 1 specifically binds oxytocin.. Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland. Acts by binding to oxytocin receptor (OXTR) (PubMed : 18174156).
See full target information OXT

Additional targets

Oxytocin-neurophysin 1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of cellular and molecular medicine 28:e70143 PubMed39383106

2024

SUN1 inhibits osteogenesis and promotes adipogenesis of human adipose-derived stem cells by regulating α-tubulin and CD36 expression.

Applications

Unspecified application

Species

Unspecified reactive species

Tingyu Fan,Jinhui Zhu,Wenqing Liu,Rongmei Qu,Asmat Ullah Khan,Yulian Shi,Jiaxuan Liu,Zhitao Zhou,Chujiang Xu,Jingxing Dai,Jun Ouyang
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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