AB217212

Anti-Oxytocin Receptor antibody

Name: Anti-Oxytocin Receptor antibody (ab217212) | Abcam
Brand: Abcam Limited
SKU: AB217212
Price: 430 USD
Availability: InStock
Rating: 5 (3 reviews)

(3 Reviews)

(13 Publications)

Rabbit Polyclonal Oxytocin Receptor antibody. Suitable for WB and reacts with Mouse samples. Cited in 13 publications. Immunogen corresponding to Synthetic Peptide within Mouse Oxtr aa 300 to C-terminus conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

Oxytocin receptor, OT-R, Oxtr

1 Images

Lab

Western blot - Anti-Oxytocin Receptor antibody (AB217212)

All lanes:

Western blot - Anti-Oxytocin Receptor antibody (ab217212) at 1/300 dilution

All lanes:

Mouse brain lysates

Secondary

All lanes:

Conjugated secondary antibody at 1/10000 dilution

Predicted band size: 43 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse

Applications

applications

Immunogen

Synthetic Peptide within Mouse Oxtr aa 300 to C-terminus conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P97926

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/300", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The oxytocin receptor (OTR) also known as OXTR is a G-protein-coupled receptor that primarily binds the neuropeptide hormone oxytocin. It has a molecular mass of approximately 43 kDa. This receptor is expressed in diverse tissues including the brain uterus mammary glands and heart. It plays a significant role in signal transduction processes converting extracellular hormonal signals into specific intracellular effects that facilitate various physiological functions.

Biological function summary

The oxytocin receptor exhibits involvement in many reproductive and social behaviors. Despite not functioning as part of a larger complex OTR activation facilitates processes such as uterine contraction milk ejection and social bonding. Activation of this receptor influences neuronal circuits in the brain supporting behaviors linked to emotion and social memory which are fundamental to maternal behaviors and pair bonding.

Pathways

The oxytocin receptor participates in critical signaling cascades including the phosphatidylinositol-calcium second messenger system. Through this pathway the receptor activates protein kinase C and increases intracellular calcium levels. This pathway often involves interaction with other proteins such as vasopressin receptors which have overlapping functions in fluid balance and cardiovascular regulation.

The oxytocin receptor has associations with conditions like autism spectrum disorder and postpartum depression. These disorders suggest that altered oxytocin receptor signaling may contribute to atypical social behavior and mood regulation. Additionally the receptor's interaction with proteins like the vasopressin receptor influences susceptibility to these neuropsychiatric conditions highlighting its role in neurological health.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

See full target information Oxtr

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Publications (13)

Recent publications for all applications. Explore the full list and refine your search

Pharmaceutics 16: PubMed38931882

2024

Oxytocin Receptors on Calvarial Periosteal Innervation: Therapeutic Target for Post-Traumatic Headache?

Applications

Unspecified application

Species

Unspecified reactive species

Vimala N Bharadwaj,Michael Klukinov,Robert Paul Cowan,Nazanin Mahinparvar,David John Clark,David Clifford Yeomans

Journal of psychiatry & neuroscience : JPN 49:E192-E207 PubMed38816029

2024

Oxytocin neurons in the paraventricular nucleus and fear empathy among male mice.

Applications

Unspecified application

Species

Unspecified reactive species

Lu Zhang,Hai-Chao Chen,Bing Li,Jia-Xin Cao,Xiao-Mei Su,Yi-Ting Kang,Li-Ping Gao,Yu-Hong Jing

The Journal of physiology 602:3375-3400 PubMed38698722

2024

Oxytocin and corticotropin-releasing hormone exaggerate nucleus tractus solitarii neuronal and synaptic activity following chronic intermittent hypoxia.

Applications

Unspecified application

Species

Unspecified reactive species

Procopio Gama de Barcellos Filho,Heather A Dantzler,Eileen M Hasser,David D Kline

Journal of periodontal research 59:280-288 PubMed38226427

2024

Oxytocin alleviates periodontitis in adult rats.

Applications

Unspecified application

Species

Unspecified reactive species

Ganna Dmytrenko,Javier Fernández-Solari,Fernando Correa,Andrea De Laurentiis

Neuroendocrinology 113:343-360 PubMed36044869

2022

Excitatory Effects of Astrocytic Hydrogen Sulfide on the Electrical Activity of Oxytocin Neurons in the Supraoptic Nucleus.

Applications

Unspecified application

Species

Unspecified reactive species

Hongyang Wang,Yunhao Jiang,Xiaoran Wang,Haitao Liu,Dongyang Li,Shuo Ling,Shuwei Jia,Xiaoyu Liu,Yang Liu,Chunmei Hou,Yu-Feng Wang

International journal of molecular sciences 22: PubMed34576011

2021

Effects of Prenatal Phthalate Exposure and Childhood Exercise on Maternal Behaviors in Female Rats at Postpartum: A Role of Methylation in the Hypothalamus.

Applications

Unspecified application

Species

Unspecified reactive species

Yi-Ju Lee,Hwai-Ting Lin,Muhammad Asad Chaudhary,Yi-Ching Lee,Dean-Chuan Wang

Frontiers in pharmacology 12:639571 PubMed34483895

2021

Oxytocin Attenuates Methamphetamine-Induced Apoptosis Oxytocin Receptor in Rat Hippocampal Neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Chunli Li,Haipeng Wang,Min Wang,Chunyun Chen,Fei Bai,Mengqi Ban,Chunfu Wu

Cerebellum (London, England) 20:922-930 PubMed33834423

2021

Epigenetic Regulation of Neural Transmission after Cerebellar Fastigial Nucleus Lesions in Juvenile Rats.

Applications

Unspecified application

Species

Unspecified reactive species

Simeon O A Helgers,Svilen Angelov,Marc A N Muschler,Alexander Glahn,Shadi Al-Afif,Yazeed Al Krinawe,Elvis J Hermann,Joachim K Krauss,Helge Frieling,Kerstin Schwabe,Mathias Rhein

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 36:20-23 PubMed33305666

2020

Oxytocinergic regulation in pathogenesis of pelvic pain caused by adenomyosis.

Applications

Unspecified application

Species

Unspecified reactive species

Mekan Orazov,Victor Radzinsky,Olga Sharapova,Igor Kostin,Yurii Chitanava

Autonomic neuroscience : basic & clinical 230:102758 PubMed33288445

2020

Corrigendum to "Exaggerated potassium current reduction by oxytocin in visceral sensory neurons following chronic intermittent hypoxia" [Auton Neurosci. 229 2020 Sep 28 102735].

Applications

Unspecified application

Species

Unspecified reactive species

Heather A Dantzler,David D Kline

View all publications

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Product promise

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Anti-Oxytocin Receptor antibody

Western blot - Anti-Oxytocin Receptor antibody (AB217212)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (13)

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