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AB190076

Anti-P cadherin antibody - N-terminal

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(5 Publications)

Rabbit Polyclonal CADH3 antibody. N-terminal. Suitable for WB, IHC-P, Flow Cyt (Intra) and reacts with Mouse, Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human CDH3 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

CDHP, CDH3, Cadherin-3, Placental cadherin, P-cadherin

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-P cadherin antibody - N-terminal (AB190076)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-P cadherin antibody - N-terminal (AB190076)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human prostate carcinoma tissue labeling P cadherin with ab190076 at 10 μg/ml, followed by peroxidase-conjugated secondary antibody and DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-P cadherin antibody - N-terminal (AB190076)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-P cadherin antibody - N-terminal (AB190076)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human pancreatic duct tissue labeling P cadherin with ab190076 at 10 μg/ml.

Flow Cytometry (Intracellular) - Anti-P cadherin antibody - N-terminal (AB190076)
  • Flow Cyt (Intra)

Supplier Data

Flow Cytometry (Intracellular) - Anti-P cadherin antibody - N-terminal (AB190076)

Intracellular flow cytometric analysis of NCI-H292 cells labeling P Cadherin with ab190076 at 1/10 dilution (bottom histogram) compared to negative control cells (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Western blot - Anti-P cadherin antibody - N-terminal (AB190076)
  • WB

Supplier Data

Western blot - Anti-P cadherin antibody - N-terminal (AB190076)

All lanes:

Western blot - Anti-P cadherin antibody - N-terminal (ab190076) at 1/1000 dilution

All lanes:

NIH 3T3 cell lysate at 35 µg

Predicted band size: 91 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, IHC-P, Flow Cyt (Intra)

applications

Immunogen

Synthetic Peptide within Human CDH3 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P22223

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "FlowCytIntra" : {"fullname" : "Flow Cytometry (Intracellular)", "shortname":"Flow Cyt (Intra)"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "10 µg/mL", "IHCP-species-notes": "<p></p>", "FlowCytIntra-species-checked": "testedAndGuaranteed", "FlowCytIntra-species-dilution-info": "", "FlowCytIntra-species-notes": "<p><a href='/en-us/products/primary-antibodies/rabbit-igg-polyclonal-isotype-control-chip-grade-ab171870'>ab171870</a> - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.</p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "FlowCytIntra-species-checked": "guaranteed", "FlowCytIntra-species-dilution-info": "", "FlowCytIntra-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.09% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

P cadherin also known as cadherin-3 or CDH3 is a calcium-dependent cell-cell adhesion glycoprotein. Scientists often refer to it as P-cadherin and it belongs to the cadherin protein family which includes other members like E-cadherin and N-cadherin. The molecular mass of P cadherin is approximately 120 kDa. It is mainly expressed in epithelial tissues including the basal side of scalp and mammary glands acting as an important mediator in maintaining tissue integrity.
Biological function summary

P cadherin plays an important role in facilitating cell adhesion and establishing proper tissue architecture. It often forms part of a larger complex by interacting with catenins including beta-catenin which helps link the cadherin itself to the actin cytoskeleton. Through these interactions P cadherin influences processes such as cell sorting boundary formation and cell polarization essential for embryonic development and tissue homeostasis.

Pathways

Cell adhesion and signal transduction are influenced by P cadherin through its involvement in the Wnt signaling pathway and cadherin-catenin complex. Within the Wnt pathway P cadherin interacts with other key proteins such as beta-catenin which transduces signals leading to gene expression changes. This interaction is important for controlling cellular processes including cell proliferation and differentiation.

P cadherin associates with various cancer types particularly breast and prostate cancers. Altered expression or dysfunction of P cadherin correlates with tumor progression and metastasis. Its interaction with E-cadherin may also contribute to the development and progression of skin disease hypotrichosis with juvenile macular dystrophy. Understanding the role of P cadherin within these contexts offers potential for developing targeted therapies and diagnostic tools.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
See full target information CDH3
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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Biomolecules 11: PubMed33921267

2021

ADAMTS19 Suppresses Cell Migration and Invasion by Targeting S100A16 via the NF-κB Pathway in Human Gastric Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yingming Jiang,Xihu Yu,Yandong Zhao,Jintuan Huang,Tuoyang Li,Hao Chen,Junyi Zhou,Zhenze Huang,Zuli Yang

Biology of reproduction : PubMed32915209

2020

Maternal high fat diet-induced obesity affects trophoblast differentiation and placental function in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Tobias Kretschmer,Eva-Maria Turnwald,Ruth Janoschek,Peter Zentis,Inga Bae-Gartz,Tim van Beers,Marion Handwerk,Maria Wohlfarth,Mojgan Ghilav,Wilhelm Bloch,Eva Hucklenbruch-Rother,Jörg Dötsch,Sarah Appel

Genes 10: PubMed31652793

2019

Deregulated Adhesion Program in Palatal Keratinocytes of Orofacial Cleft Patients.

Applications

Unspecified application

Species

Unspecified reactive species

Aysel Mammadova,Carine E L Carels,Jie Zhou,Christian Gilissen,Maria P A C Helmich,Zhuan Bian,Huiqing Zhou,Johannes W Von den Hoff

Molecular carcinogenesis 59:32-44 PubMed31621118

2019

Long noncoding RNA ADAMTS9-AS2 suppresses the progression of esophageal cancer by mediating CDH3 promoter methylation.

Applications

Unspecified application

Species

Unspecified reactive species

Donglei Liu,Kai Wu,Yang Yang,Dengyan Zhu,Chunyang Zhang,Song Zhao

Journal of cellular biochemistry 121:299-312 PubMed31190436

2019

miR-124a enhances therapeutic effects of bone marrow stromal cells transplant on diabetic nephropathy-related epithelial-to-mesenchymal transition and fibrosis.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaojun Cai,Lei Wang,Xuling Wang,Fengyan Hou
View all publications
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Product promise

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