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AB170904

Anti-P Glycoprotein antibody [EPR10364-57]

4

(12 Reviews)

|

(245 Publications)

Anti-P Glycoprotein antibody [EPR10364-57] (ab170904) is a rabbit monoclonal antibody detecting P Glycoprotein in Western Blot, IHC-P. Suitable for Human, Mouse, Rat.

- KO validated for confirmed specificity
- Biophysical QC for unrivalled batch-batch consistency
- Over 190 publications

View Alternative Names

CD243, MDR1, PGY1, ABCB1, ATP-dependent translocase ABCB1, ATP-binding cassette sub-family B member 1, Multidrug resistance protein 1, P-glycoprotein 1, Phospholipid transporter ABCB1

15 Images
Western blot - Anti-P Glycoprotein antibody [EPR10364-57] (AB170904)
  • WB

Lab

Western blot - Anti-P Glycoprotein antibody [EPR10364-57] (AB170904)

Lane 1 : Wild type HAP1 whole cell lysate (20 μg)
Lane 2 : P Glycoprotein knockout HAP1 whole cell lysate (20 μg)
Lane 3 : HepG2 whole cell lysate (20 μg)

Lanes 1 - 3 : Merged signal (red and green). Green - ab170904 observed at 160 kDa. Red - loading control, ab8245, observed at 37 kDa.

ab170904 was shown to specifically react with P Glycoprotein when P Glycoprotein knockout samples were used. Wild-type and P Glycoprotein knockout samples were subjected to SDS-PAGE. ab170904 and ab8245 (Mouse anti GAPDH loading control) were incubated overnight at 4°C at 1 ug/ml and 1/10000 dilution respectively.

Blots were developed with Goat anti-Rabbit IgG H&L (IRDye® 800CW) preabsorbed ab216773 and Goat anti-Mouse IgG H&L (IRDye® 680RD) preabsorbed ab216776 secondary antibodies at 1/10000 dilution for 1 hour at room temperature before imaging.

All lanes:

Western blot - Anti-P Glycoprotein antibody [EPR10364-57] (ab170904)

Predicted band size: 141 kDa

false

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-P Glycoprotein antibody [EPR10364-57] (AB170904)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-P Glycoprotein antibody [EPR10364-57] (AB170904)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis human kidney tissue labeling P Glycoprotein with unpurified ab170904 at 1/250 dilution.

Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-P Glycoprotein antibody [EPR10364-57] (AB170904)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-P Glycoprotein antibody [EPR10364-57] (AB170904)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human kidney tissue sections labeling P Glycoprotein with purified ab170904 at 1/1200 dilution (0.24 μg/ml). Heat mediated antigen retrieval was performed using ab93684 (Tris/EDTA buffer, pH 9.0) ImmunoHistoProbe one step HRP Polymer (ready to use) was used as the secondary antibody. Hematoxylin was used as a counterstain.

Negative control : PBS instead of the primary antibody (inset).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-P Glycoprotein antibody [EPR10364-57] (AB170904)
  • IHC-P

Lab

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-P Glycoprotein antibody [EPR10364-57] (AB170904)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human brain tissue labeling P Glycoprotein with purified ab170904 at 1/100. Heat mediated antigen retrieval was performed using Tris/EDTA buffer pH 9. A prediluted HRP-polymer conjugated anti-rabbit IgG was used as the secondary antibody.

Counterstained with hematoxylin.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-P Glycoprotein antibody [EPR10364-57] (AB170904)
  • IHC-P

Lab

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-P Glycoprotein antibody [EPR10364-57] (AB170904)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human brain tissue labeling P Glycoprotein with unpurified ab170904 at 1/20. Heat mediated antigen retrieval was performed using Tris/EDTA buffer pH 9. A prediluted HRP-polymer conjugated anti-rabbit IgG was used as the secondary antibody.

Counterstained with hematoxylin.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-P Glycoprotein antibody [EPR10364-57] (AB170904)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-P Glycoprotein antibody [EPR10364-57] (AB170904)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human hepatocellular carcinoma tissue labeling P Glycoprotein with unpurified ab170904 at 1/250 dilution.

Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-P Glycoprotein antibody [EPR10364-57] (AB170904)
  • IHC-P

Lab

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-P Glycoprotein antibody [EPR10364-57] (AB170904)

Immunohistochemical analysis of formalin fixed paraffin embedded human kidney labelling P Glycoprotein with ab170904 at a concentration of 1µg/ml. The immunostaining was performed on a Ventana DISCOVERY ULTRA (Roche Tissue Diagnostics) instrument with a OptiView DAB IHC Detection Kit. Heat mediated antigen retrieval was performed with DISCOVERY cell conditioning solution (CC1) 100°C, pH8.5 for 32mins. ab170904 Anti-P Glycoprotein antibody [EPR10364-57] was incubated for 16mins at 37°C. Sections were counterstained with Hematoxylin II. Image inset shows absence of staining in secondary antibody only control. Customers are encouraged to optimise antigen retrieval conditions, antibody concentration, incubation times and temperature for best results in their own IHC assay workflow (automated and manual).

Western blot - Anti-P Glycoprotein antibody [EPR10364-57] (AB170904)
  • WB

Supplier Data

Western blot - Anti-P Glycoprotein antibody [EPR10364-57] (AB170904)

All lanes:

Western blot - Anti-P Glycoprotein antibody [EPR10364-57] (ab170904) at 1/1000 dilution

Lane 1:

HeLa (Human epithelial cell line from cervix adenocarcinoma) cell lysate at 10 µg

Lane 2:

HepG2 (Human liver hepatocellular carcinoma cell line) cell lysate at 10 µg

Lane 3:

HEK-293T (Human epithelial cell line from embryonic kidney transformed with large T antigen) cell lysate at 10 µg

Lane 4:

Human fetal brain tissue lysate at 10 µg

Secondary

All lanes:

HRP-conjugated goat anti-rabbit IgG at 1/2000 dilution

Predicted band size: 141 kDa

true

Western blot - Anti-P Glycoprotein antibody [EPR10364-57] (AB170904)
  • WB

Lab

Western blot - Anti-P Glycoprotein antibody [EPR10364-57] (AB170904)

Blocking and diluting buffer : 5% NFDM/TBST

Exposure time : Left image -10 seconds; Right image - 1 minute.

We suggest not to boil the sample after lysis.

For 1% SDS Hot Lysates preparation protocol, please refer to the protocol section of the website and/or here.

All lanes:

Western blot - Anti-P Glycoprotein antibody [EPR10364-57] (ab170904) at 1/2000 dilution

Lanes 1 and 3:

HeLa (Human cervix adenocarcinoma epithelial cell) whole cell lysates prepared using RIPA lysis method at 15 µg

Lanes 2 and 4:

HeLa (Human cervix adenocarcinoma epithelial cell) whole cell lysate prepared using 1% SDS hot lysis method at 15 µg

Secondary

All lanes:

Western blot - Goat Anti-Rabbit IgG H&L (HRP) (<a href='/en-us/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-ab97051'>ab97051</a>) at 1/20000 dilution

Predicted band size: 141 kDa

Observed band size: 180 kDa

false

Western blot - Anti-P Glycoprotein antibody [EPR10364-57] (AB170904)
  • WB

Lab

Western blot - Anti-P Glycoprotein antibody [EPR10364-57] (AB170904)

Blocking/Dilution buffer and concentration : 5% NFDM/TBST.

All lanes:

Western blot - Anti-P Glycoprotein antibody [EPR10364-57] (ab170904) at 1/200 dilution

Lane 1:

HepG2 (Human liver hepatocellular carcinoma cell line) cell lysate at 20 µg

Lane 2:

Mouse brain tissue lysate at 20 µg

Lane 3:

Rat brain tissue lysate at 20 µg

Secondary

All lanes:

Peroxidase-conjugated goat anti-rabbit IgG (H+L) at 1/1000 dilution

Predicted band size: 141 kDa

Observed band size: 180 kDa

false

Western blot - Anti-P Glycoprotein antibody [EPR10364-57] (AB170904)
  • WB

Lab

Western blot - Anti-P Glycoprotein antibody [EPR10364-57] (AB170904)

Blocking/Dilution buffer and concentration : 5% NFDM/TBST.

All lanes:

Western blot - Anti-P Glycoprotein antibody [EPR10364-57] (ab170904) at 1/1000 dilution

Lane 1:

HepG2 (Human liver hepatocellular carcinoma cell line) cell lysate at 20 µg

Lane 2:

Mouse brain tissue lysate at 20 µg

Lane 3:

Rat brain tissue lysate at 20 µg

Secondary

All lanes:

Peroxidase-conjugated goat anti-rabbit IgG (H+L) at 1/1000 dilution

Predicted band size: 141 kDa

Observed band size: 180 kDa

false

Western blot - Anti-P Glycoprotein antibody [EPR10364-57] (AB170904)
  • WB

Supplier Data

Western blot - Anti-P Glycoprotein antibody [EPR10364-57] (AB170904)

All lanes:

Western blot - Anti-P Glycoprotein antibody [EPR10364-57] (ab170904) at 1/1000 dilution

Lane 1:

Mouse brain tissue lysate

Lane 2:

Mouse heart tissue lysate

Lane 3:

Mouse kidney tissue lysate

Lane 4:

Mouse spleen tissue lysate

Secondary

All lanes:

HRP-conjugated goat anti-rabbit IgG (H+L) at 1/2000 dilution

Predicted band size: 141 kDa

Observed band size: 180 kDa

true

Exposure time: 2min

Western blot - Anti-P Glycoprotein antibody [EPR10364-57] (AB170904)
  • WB

Lab

Western blot - Anti-P Glycoprotein antibody [EPR10364-57] (AB170904)

Blocking and diluting buffer : 5% NFDM/TBST

Exposure time : Left image - 3 seconds; Right image - 10 seconds.

We suggest not to boil the sample after lysis.

Lanes 1 - 4:

Western blot - Anti-P Glycoprotein antibody [EPR10364-57] (ab170904) at 1/2000 dilution

Lanes 1 - 4:

Western blot - Anti-P Glycoprotein antibody [EPR10364-57] - BSA and Azide free (<a href='/en-us/products/primary-antibodies/p-glycoprotein-antibody-epr10364-57-bsa-and-azide-free-ab216656'>ab216656</a>)

Lanes 1 and 3:

Raw264.7 (Mouse Abelson murine leukemia virus-induced tumor macrophage) whole cell lysates prepared using RIPA lysis method at 15 µg

Lanes 2 and 4:

Raw264.7 (Mouse Abelson murine leukemia virus-induced tumor macrophage) whole cell lysate prepared using 1%SDS lysis method at 15 µg

Secondary

All lanes:

Western blot - Goat Anti-Rabbit IgG H&L (HRP) (<a href='/en-us/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-ab97051'>ab97051</a>) at 1/20000 dilution

Predicted band size: 141 kDa

Observed band size: 180 kDa

false

Western blot - Anti-P Glycoprotein antibody [EPR10364-57] (AB170904)
  • WB

Lab

Western blot - Anti-P Glycoprotein antibody [EPR10364-57] (AB170904)

Blocking and diluting buffer : 5% NFDM/TBST.

All lanes:

Western blot - Anti-P Glycoprotein antibody [EPR10364-57] (ab170904) at 0.1 µg/mL

Lane 1:

C6 (Rat glial tumor glial cell) whole cell lysates prepared using RIPA lysis method - unboiled at 15 µg

Lane 2:

C6 (Rat glial tumor glial cell) whole cell lysates prepared using 1% SDS Hot lysis method - unboiled at 15 µg

Lane 3:

C6 (Rat glial tumor glial cell) whole cell lysates prepared using RIPA lysis method - boiled

Lane 4:

C6 (Rat glial tumor glial cell) whole cell lysates prepared using 1% SDS Hot lysis method - boiled

Secondary

All lanes:

Western blot - Goat Anti-Rabbit IgG H&L (HRP) (<a href='/en-us/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-ab97051'>ab97051</a>) at 1/20000 dilution

Predicted band size: 141 kDa

Observed band size: 180 kDa

false

Western blot - Anti-P Glycoprotein antibody [EPR10364-57] (AB170904)
  • WB

Supplier Data

Western blot - Anti-P Glycoprotein antibody [EPR10364-57] (AB170904)

All lanes:

Western blot - Anti-P Glycoprotein antibody [EPR10364-57] (ab170904) at 1/1000 dilution

Lane 1:

Rat brain tissue lysate

Lane 2:

Rat heart tissue lysate

Lane 3:

Rat kidney tissue lysate

Lane 4:

Rat spleen tissue lysate

Predicted band size: 141 kDa

Observed band size: 180 kDa

false

Exposure time: 2min

  • Carrier free

    Anti-P Glycoprotein antibody [EPR10364-57] - BSA and Azide free

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-P Glycoprotein antibody [EPR10364-57]

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR10364-57

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

IHC-P, WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Specificity

P-glycoprotein 1, also known as Multidrug resistance protein 1, has a predicted molecular weight of 141 kDa, however it has 3 potential glycosylation sites (N-linked) which may affect the migration of the protein. In our hands this antibody detects a predominant protein band migrating in the region of 180-200 kDa and typically will demonstrate a smear on the membrane in the region of the 150-300 kDa due to the glycosylation profile of the protein. It may be necessary to optimise your cell or tissue lysis protocol to efficiently extract P-glycoprotein 1 as it is a multi-pass membrane protein. Abcam recommends not boiling the sample after lysis.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p>For optimal detection Abcam recommends not boiling the sample after lysis.</p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/1200", "IHCP-species-notes": "<p><strong>For unpurified use at 1/20 - 1/100</strong></p> Perform heat-mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol." }, "Mouse": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p>For optimal detection Abcam recommends not boiling the sample after lysis.</p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" }, "Rat": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p>For optimal detection Abcam recommends not boiling the sample after lysis.</p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }
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Product details

Product Specifications
Anti-P Glycoprotein antibody [EPR10364-57] (ab170904) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in IHC-P, WB in human, mouse, rat samples.
Anti-P Glycoprotein antibody [EPR10364-57] (ab170904) specifically detects P Glycoprotein (UniProt ID: P08183; Molecular weight: 141kDa) and is sold in 100 µL and 1 mL selling sizes.

Quality and Validation
Abcam's high quality manufacturing and validation processes ensure Anti-P Glycoprotein antibody [EPR10364-57] (ab170904) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility.
The specificity of Anti-P Glycoprotein antibody [EPR10364-57] (ab170904) has been confirmed by testing in knockout samples.
Anti-P Glycoprotein antibody [EPR10364-57] (ab170904) has been cited over 192 times in peer reviewed journals and is trusted by the scientific community.
Anti-P Glycoprotein antibody [EPR10364-57] (ab170904) has 10 independent reviews from customers.

Related Products
Antibody clone EPR10364-57 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 647 (ab225231).

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

P-glycoprotein also known as P-gp MDR1 transporter or ABCB1 is a well-characterized efflux transporter with a molecular mass of approximately 170 kDa. This protein is expressed in various normal tissues such as the liver intestine kidney blood-brain barrier and placenta. It is located on the cell membrane where it functions to expel a wide variety of substrates out of cells using energy derived from ATP hydrolysis. This capability of pumping out toxins and xenobiotics makes P-glycoprotein an important player in cellular detoxification.
Biological function summary

P-glycoprotein acts as a protective mechanism against toxic substances and drugs within the body. It is a member of the ATP-binding cassette (ABC) transporter family which is critical for their ability to transport molecules across membranes. P-glycoprotein is not typically part of a larger protein complex but can interact with other membrane proteins to facilitate its function. Its role in drug metabolism and excretion is vital for maintaining the balance and elimination of harmful substances.

Pathways

P-glycoprotein plays a significant role in the pharmacokinetics of drugs within the body. This transporter is involved in the multi-drug resistance (MDR) pathway which impacts the efficacy of chemotherapeutic agents. P-glycoprotein also interacts with other proteins like CYP3A4 which is involved in the metabolism of many drugs. These interactions affect the concentration and distribution of therapeutic agents contributing to the body's overall drug response.

P-glycoprotein is closely associated with multi-drug resistance in cancer where its overexpression can lead to reduced effectiveness of chemotherapy. It is also implicated in disorders of the central nervous system like epilepsy where it affects drug delivery to the brain. The protein has connections with CYP3A4 in these contexts where both together influence drug metabolism and efficacy complicating treatment regimens and therapeutic outcomes in these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Translocates drugs and phospholipids across the membrane (PubMed : 2897240, PubMed : 35970996, PubMed : 8898203, PubMed : 9038218, PubMed : 35507548). Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed : 8898203). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (PubMed : 2897240, PubMed : 35970996, PubMed : 9038218).
See full target information ABCB1
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Publications (245)

Recent publications for all applications. Explore the full list and refine your search

JHEP reports : innovation in hepatology 7:101543 PubMed41070100

2025

Isolation and immortalization of human portal vein endothelial cells: A novel research tool for studying splanchnic vasculature.

Applications

Unspecified application

Species

Unspecified reactive species

Aina Anton,Sarah Shalaby,Júlia Campalans,Annabel Blasi,Yiliam Fundora,Rosa Montañés,Héctor García-Calderó,Lixin Sun,Joana Codina,Josepmaria Argemí,Olga Tura-Ceide,Joan Carles García-Pagán,Genís Campreciós,Virginia Hernández-Gea

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 56:825-830 PubMed40964104

2025

[Effect of High-Altitude Hypoxia on the Pharmacokinetics and Brain Distribution of Phenytoin Sodium in Epileptic Rats].

Applications

Unspecified application

Species

Unspecified reactive species

Xiaojing Zhang,Yan Zhong,Hongfang Mu,Wenbin Li,Xiaomin Yang,Rong Wang

Stroke and vascular neurology : PubMed40908045

2025

Head-down position after reperfusion improves cerebral ischaemic injury in rat.

Applications

Unspecified application

Species

Unspecified reactive species

Qiong Wu,Nan-Nan Zhang,Ji-Ru Cai,Yi-Na Zhang,Hui-Sheng Chen

Science advances 11:eadr8001 PubMed40901943

2025

Pulsatile sequential drug release system for cascade tumor deep penetration and differentiation therapy to enhance chemoimmunotherapy.

Applications

Unspecified application

Species

Unspecified reactive species

Fengxiang Liu,Shipeng Ning,Xia Wang,Xiaoyuan Fan,Bin Wan,Fei Sun,Lili Du,Kefan Shi,Xinpeng Zou,Ruihong Zhu,Mingxing Li,Wenwen Shen,Zhonggui He,Kaiyuan Wang,Jin Sun

Cells 14: PubMed40862755

2025

Fibroblasts Attenuate Anti-Tumor Drug Efficacy in Tumor Cells via Paracrine Interactions with Tumor Cells in 3D Plexiform Neurofibroma Cultures.

Applications

Unspecified application

Species

Unspecified reactive species

Kyungmin Ji,George J Schwenkel

PLoS pathogens 21:e1012881 PubMed40720562

2025

Targeting translation initiation yields fast-killing therapeutics against the zoonotic parasite Cryptosporidium parvum.

Applications

Unspecified application

Species

Unspecified reactive species

Meng Li,Jigang Yin,Dongqiang Wang,Beibei Zou,Guan Zhu

American journal of cancer research 15:2535-2550 PubMed40667556

2025

Exploring the role of YES1 kinase in regulating cisplatin resistance through iTRAQ-based quantitative proteomic analysis in urothelial carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Chia-Che Wu,Chung-Wen Kuo,Ming-Chun Kuo,Chang-Ting Lin,Ling-Yi Xiao,Li-Chung Chang,Yi-Hua Chen,Shih-Yu Huang,Harvey Yu-Li Su

Frontiers in oncology 15:1558184 PubMed40548120

2025

ABCG2 protein expression in tumors of patients with non-resectable pancreatic cancer treated with gemcitabine and -paclitaxel.

Applications

Unspecified application

Species

Unspecified reactive species

Susy Shim,Mette Bak Nielsen,Mikkel Eld,Jan Stenvang,Rasmus Froberg Brøndum,Britta Weber,Anne Krejbjerg Motavaf,Morten Ladekarl

Molecules (Basel, Switzerland) 30: PubMed40509228

2025

Synthesis and Biological Evaluation of Seco-Coumarin/Furoxan Hybrids as Potent Anti-Tumor Agents to Overcome Multidrug Resistance via Multiple Mechanisms.

Applications

Unspecified application

Species

Unspecified reactive species

Feng Qu,Jiachen Weng,Xiufan Wu,Shuquan Zhang,La Li,Xuqin Guo,Hongrui Liu,Ying Chen

Hepatology communications 9: PubMed40377492

2025

Antioxidant interventions reduced cytokine-induced pyroptosis of peripheral MAIT cells in patients with HBV-related cirrhosis.

Applications

Unspecified application

Species

Unspecified reactive species

Zheng Xu,Zhe Xu,Xing Fan,Meng-Meng Qu,Hongmin Wang,Jiaying Li,Lingyu Gao,Yan-Mei Jiao,Jijing Shi,Fu-Sheng Wang
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