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AB222194

Anti-p0071 antibody

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(1 Publication)

Rabbit Polyclonal p0071 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PKP4 aa 150-250.

View Alternative Names

Plakophilin-4, p0071, PKP4

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-p0071 antibody (AB222194)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-p0071 antibody (AB222194)

PFA-fixed, Triton X-100 permeabilized HepG2 (human liver hepatocellular carcinoma cell line) cells stained for p0071 (green) using ab222194 at 4 μg/ml in ICC/IF.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human PKP4 aa 150-250. The exact immunogen used to generate this antibody is proprietary information.

Q99569

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Rat": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

P0071 also known as plakophilin-7 is a member of the armadillo family and exhibits a molecular mass of approximately 135 kDa. Mechanically p0071 functions as a scaffold protein by interconnecting cytoskeletal networks in cells. It predominantly expresses in epithelial and endothelial tissues where it localizes to cell-cell junctions and contributes to the structural integrity of cells. Having both armadillo repeats and a conserved domain indicative of its α-catenin interaction potential p0071 plays a mechanical role in supporting cellular architecture.
Biological function summary

Plakophilin-7 assists in the regulation of cell adhesion and signal transduction by interacting with desmosomal plaques. As part of this role p0071 associates with other junctional proteins to integrate into larger multiprotein complexes that define cell-cell contact. It reinforces desmosomes which are adhesive complexes required for strong intercellular connections critical for maintaining tissue integrity. p0071 influences the mechanical strength and resilience of tissues against external stress making it pivotal for normal epithelial and endothelial function.

Pathways

Interactions of plakophilin-7 have implications in the regulation of Wnt and Rho signaling pathways. p0071 partners with proteins such as beta-catenin and gamma-catenin in the Wnt signaling pathway influencing cell proliferation and differentiation. Additionally it connects to the Rho family GTPases pathway impacting cytoskeletal organization and cellular dynamics. Through these pathways p0071 orchestrates complex biological responses that are essential for cellular homeostasis and development.

Plakophilin-7 holds relevance in conditions like cancer and cardiovascular disease. Altered expression or functionality of p0071 associates with tumor progression and metastasis particularly influencing epithelial-mesenchymal transition processes. In cardiovascular disorders disruptions in p0071 expression affect heart tissue integrity through links with proteins such as desmoplakin and plakoglobin. Understanding p0071’s involvement in these diseases provides insights into potential therapeutic targets to modulate its function.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques.
See full target information PKP4
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of cell biology 219: PubMed31881080

2019

Aurora A promotes chromosome congression by activating the condensin-dependent pool of KIF4A.

Applications

Unspecified application

Species

Unspecified reactive species

Elena Poser,Renaud Caous,Ulrike Gruneberg,Francis A Barr
View all publications
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