Anti-p107 (phospho T369) antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The protein p107 also known as Retinoblastoma-like protein 1 (RBL1) is a member of the retinoblastoma (RB) protein family and has a molecular weight of approximately 107 kDa. p107 is known for its role as a cell cycle regulator specifically in controlling cell cycle progression at the G1 phase. It is widely expressed in many tissues including the brain skeletal muscle and lymphoid tissues. Like other members of the RB family p107 contains an RB pocket domain important for its interactions with other proteins.

Biological function summary

Retinoblastoma-like protein 1 functions in the regulation of the cell cycle acting as an important checkpoint controller between the G1 and S phases. This protein forms a complex with E2F transcription factors which are important in controlling genes involved in cell cycle progression. The p107-E2F interaction represses transcription and inhibits the cell from proceeding to the S phase thereby ensuring proper cellular proliferation control. Moreover p107 can bind to cyclin-dependent kinases adding another layer of regulation.

Pathways

P107 plays essential roles in the RB-E2F pathway and the DNA damage response pathway. Within these pathways p107 interacts with other key proteins like p130 and pRB which together form the pocket protein family. The RB-E2F pathway controls cell cycle entry and exit while the DNA damage response pathway ensures genomic integrity. p107 acts as a mediator to pause the cell cycle during DNA damage repair collaborating with these related proteins to maintain cellular homeostasis.

Associated diseases and disorders

P107 shows notable implications in cancer and retinoblastoma. Alterations in the expression or function of p107 can lead to unregulated cell proliferation contributing to oncogenesis. In cancer disruptions in the RB-E2F pathway often involving mutations or changes in p107 pRB or related proteins can induce tumor formation. In retinoblastoma although pRB plays a more dominant role reduced functionality of p107 can exacerbate the disease by weakening cell cycle control. Therefore p107 occupies an essential position in both safeguarding against diseases and being a potential factor in disease progression when dysregulated.