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AB229151

Anti-P2X2 antibody

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(1 Publication)

Rabbit Polyclonal P2X2 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human P2RX2.

View Alternative Names

P2X2, P2RX2, P2X purinoceptor 2, ATP receptor, Purinergic receptor

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-P2X2 antibody (AB229151)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-P2X2 antibody (AB229151)

Paraffin-embedded human breast cancer tissue stained for P2X2 using ab229151 at 1/500 dilution in immunohistochemical analysis.

Western blot - Anti-P2X2 antibody (AB229151)
  • WB

Supplier Data

Western blot - Anti-P2X2 antibody (AB229151)

10% SDS-PAGE

All lanes:

Western blot - Anti-P2X2 antibody (ab229151) at 1/1000 dilution

All lanes:

HepG2 (human liver hepatocellular carcinoma cell line) whole cell lysate at 30 µg

Predicted band size: 51 kDa

false

Western blot - Anti-P2X2 antibody (AB229151)
  • WB

Supplier Data

Western blot - Anti-P2X2 antibody (AB229151)

10% SDS-PAGE

All lanes:

Western blot - Anti-P2X2 antibody (ab229151) at 1/500 dilution

All lanes:

Mouse brain tissue extract at 50 µg

Predicted band size: 51 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human P2RX2. The exact immunogen used to generate this antibody is proprietary information.

Q9UBL9

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The P2X2 receptor also called P2RX2 is a ligand-gated ion channel that opens in response to the binding of extracellular ATP. It belongs to the P2X receptor family and has a molecular weight of approximately 51 kDa. P2X2 is expressed in a variety of tissues most notably in the nervous system including the brain and spinal cord as well as other excitable tissues like skeletal muscle. Its presence contributes to the regulation of synaptic transmission and neuromuscular communication.
Biological function summary

P2X2 participates in the modulation of cellular excitability and neurotransmitter release. It forms homomeric channels or heteromeric channels by assembling with other P2X subunits such as P2X3. Its role becomes significant in the context of the central and peripheral nervous systems where it influences ion flow particularly for sodium potassium and calcium across the cell membrane. The ion flow alters the membrane potential and affects neuronal firing and signal propagation.

Pathways

P2X2 integrates into the purinergic signaling pathway and plays a part in synaptic transmission modulation. It influences various biological processes through interactions with related proteins such as other members of the P2X family like P2X4 and P2X7. These interactions fine-tune cellular responses to ATP in the nervous system and are important for maintaining physiological processes like neurotransmission and pain perception.

P2X2 associates with conditions like neuropathic pain and hearing loss. The receptor's function connects to auditory pathways where its dysfunction might contribute to cochlear disorders. Additionally through its role in purinergic signaling P2X2 links with other proteins involved in pain pathways such as P2X3 whose modulation could provide therapeutic targets for pain management.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium (PubMed : 10570044, PubMed : 31636190). Activation by extracellular ATP induces a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis (By similarity). In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling (PubMed : 23345450). Mediates synaptic transmission between neurons and from neurons to smooth muscle (By similarity).
See full target information P2RX2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Oncology letters 18:4421-4428 PubMed31611951

2019

STAMBPL1 knockdown has antitumour effects on gastric cancer biological activities.

Applications

Unspecified application

Species

Unspecified reactive species

Da-Jun Yu,Jun Qian,Xin Jin,Jing Li,Chen-Xu Guo,Xi-Cheng Yue
View all publications
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