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AB221705

Anti-P2X5 antibody

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(1 Publication)

Rabbit Polyclonal P2X5 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human P2RX5 aa 100-200.

View Alternative Names

P2X5, P2X5FL, P2RX5, P2X purinoceptor 5, ATP receptor, Purinergic receptor

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-P2X5 antibody (AB221705)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-P2X5 antibody (AB221705)

PFA-fixed, Triton X-100 permeabilized HeLa (human epithelial cell line from cervix adenocarcinoma) cells stained for P2X5 (green) using ab221705 at 4 μg/ml in ICC/IF.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human P2RX5 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.

Q93086

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The P2X5 receptor also known as P2RX5 is a member of the P2X family of receptors which are ligand-gated ion channels activated by extracellular ATP. P2X5 is a protein that weighs approximately 53 kDa. It is expressed in various tissues particularly prominent in the immune and nervous system. The receptor facilitates the movement of ions such as calcium sodium and potassium across the cell membrane influencing cellular depolarization and signaling.
Biological function summary

P2X5 plays a significant role in modulating immune responses and synaptic transmission. It forms homomeric or heteromeric complexes with other P2X receptor subtypes like P2X1 and P2X2 affecting its functionality. The receptor's presence in the lymphatic tissues suggests its involvement in lymphocyte proliferation and function. Additionally P2X5 influences neurotransmitter release in neural contexts impacting neuron-to-neuron communication.

Pathways

P2X5 participates prominently in the purinergic signaling pathway and has roles in the immune response pathway. It is involved with related proteins like P2X1 and P2X4 in mediating several physiological functions. In purinergic signaling the activation of P2X5 receptor channels by ATP affects numerous downstream processes involving calcium influx which is critical to the function of both neuronal and immune pathways.

P2X5 has been linked to certain inflammatory conditions and neurological disorders. For instance its pro-inflammatory roles make it a point of interest in studying autoimmune diseases. Furthermore abnormalities in P2X5 activity have been associated with multiple sclerosis implicating it in the demyelination processes. The receptor interacts with pro-inflammatory cytokines and such interactions may exacerbate disease states highlighting the therapeutic potential of targeting P2X5 in treatment interventions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Isoform 6. ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium (PubMed : 12761352). Unlike, other P2RX receptors, the P2X5 receptor is also permeable to chloride (PubMed : 12761352). May play a supporting role in the inflammatory response (By similarity).. Isoform 1. Non-functional.
See full target information P2RX5
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature immunology 24:1149-1160 PubMed37202489

2023

Conserved stromal-immune cell circuits secure B cell homeostasis and function.

Applications

Unspecified application

Species

Unspecified reactive species

Mechthild Lütge,Angelina De Martin,Cristina Gil-Cruz,Christian Perez-Shibayama,Yves Stanossek,Lucas Onder,Hung-Wei Cheng,Lisa Kurz,Nadine Cadosch,Charlotte Soneson,Mark D Robinson,Sandro J Stoeckli,Burkhard Ludewig,Natalia B Pikor
View all publications
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