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AB140859

Anti-P2Y1 antibody - C-terminal

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(2 Publications)

Rabbit Polyclonal P2Y1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human P2RY1.

View Alternative Names

P2Y purinoceptor 1, P2Y1, ADP receptor, Purinergic receptor, P2RY1

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-P2Y1 antibody - C-terminal (AB140859)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-P2Y1 antibody - C-terminal (AB140859)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human, Adrenal tissue labeling P2Y1 with ab140859 at 5 μg/ml.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human P2RY1. The exact immunogen used to generate this antibody is proprietary information.

P47900

Specificity

BLAST analysis of the peptide immunogen showed no homology with other Human proteins.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "2-3 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Bat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Common marmoset": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Dog": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Elephant": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Guinea pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Hamster": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Horse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Opossum": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rabbit": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Xenopus laevis": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The P2Y1 receptor also known as P2RY1 is a G protein-coupled receptor with a molecular mass of approximately 42 kDa. This receptor is expressed in various tissues including platelets endothelial cells and certain brain regions. P2Y1 primarily binds to extracellular nucleotides such as ADP and ATP initiating signaling pathways that involve intracellular calcium mobilization and activation of phospholipase C. Its role as a receptor for purines distinguishes it as a significant component in cellular communication processes.
Biological function summary

The P2Y1 receptor participates in platelet aggregation and the regulation of blood clot formation. It exists as part of a multi-receptor complex but can function independently. P2Y1 activation leads to shape change and aggregation of platelets contributing to hemostasis. Additionally its expression in neuronal tissue suggests involvement in neurotransmission and cognitive functions although the full spectrum of its biological roles continues to be studied.

Pathways

P2Y1 integrates into signal transduction cascades involving phosphoinositide metabolism and the regulation of intracellular calcium. The receptor is a part of the purinergic signaling pathway which includes other receptors like P2Y12. These signals play a role in platelet activation and vascular integrity where P2Y1 works in conjunction with other proteins like Gq alpha subunit to propagate cellular responses essential for maintaining vascular homeostasis and responding to vascular injury.

P2Y1 exhibits connections to thrombotic disorders and neurological conditions such as stroke. The receptor's role in platelet activation implicates it in the pathogenesis of thrombotic events where excessive or dysfunctional aggregation can lead to disorders like deep vein thrombosis. In the context of neural activity abnormal P2Y1 signaling may influence the risk or severity of ischemic stroke interacting with cyclooxygenase pathway components involved in inflammation and cerebral blood flow regulation. Understanding these interactions solidifies P2Y1 as a promising target for therapeutic interventions in these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor for extracellular adenine nucleotides such as ADP (PubMed : 25822790, PubMed : 9038354, PubMed : 9442040). In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation (PubMed : 9442040).
See full target information P2RY1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 14:5300 PubMed37652903

2023

Purinergic signaling mediates neuroglial interactions to modulate sighs.

Applications

Unspecified application

Species

Unspecified reactive species

Liza J Severs,Nicholas E Bush,Lely A Quina,Skyler Hidalgo-Andrade,Nicholas J Burgraff,Tatiana Dashevskiy,Andy Y Shih,Nathan A Baertsch,Jan-Marino Ramirez

The Journal of physiology 595:4631-4645 PubMed28481415

2017

Large-conductance Ca -activated K channel activation by apical P2Y receptor agonists requires hydrocortisone in differentiated airway epithelium.

Applications

Unspecified application

Species

Unspecified reactive species

Nathan A Zaidman,Angela Panoskaltsis-Mortari,Scott M O'Grady
View all publications
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