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AB122359

Anti-P2Y10 antibody

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(1 Publication)

Rabbit Polyclonal P2Y10 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human P2RY10 aa 200-250.

View Alternative Names

Putative P2Y purinoceptor 10, P2Y10, P2Y-like receptor, P2RY10

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-P2Y10 antibody (AB122359)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-P2Y10 antibody (AB122359)

ab122359, at 1/25 dilution, staining P2Y10 in paraffin-embedded Human tonsil tissue by Immunohistochemistry.

Western blot - Anti-P2Y10 antibody (AB122359)
  • WB

Unknown

Western blot - Anti-P2Y10 antibody (AB122359)

All lanes:

Western blot - Anti-P2Y10 antibody (ab122359) at 1/250 dilution

Lane 1:

RT-4 cell lysate

Lane 2:

U-251 MG cell lysate

Lane 3:

Human plasma lysate

Lane 4:

Human liver lysate

Lane 5:

Human tonsil lysate

Predicted band size: 39 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human P2RY10 aa 200-250. The exact immunogen used to generate this antibody is proprietary information.

O00398

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/50", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

P2Y10 also known as P2Y10 receptor or GPR99 is a G protein-coupled receptor (GPCR) with an approximate mass of 40 kDa. This receptor primarily binds to nucleotide ligands specifically lysophosphatidic acid (LPA). P2Y10 is expressed in a variety of tissues including the spleen lungs and liver. It plays a significant role in cellular signaling by activating downstream pathways in response to external stimuli.
Biological function summary

P2Y10 receptor functions as a modulator of immune response and cellular communication. As part of the P2Y receptor family it interacts closely with LPA to influence various physiological processes such as cell proliferation survival and migration. Despite its role in these functions the receptor does not function independently; instead it associates with other molecular complexes that help transmit signals inside the cell.

Pathways

The P2Y10 receptor influences the LPA signaling pathway which plays an important part in cellular communication and tissue homeostasis. LPA signaling involves interactions with other GPCRs and various kinases such as PI3K and MAPK. P2Y10 is interrelated with receptors like P2Y1 which share overlapping signaling cascades and contribute to similar physiological responses indicating their cooperative roles in signal transduction mechanisms.

P2Y10 has associations with immune-related conditions such as asthma and inflammatory diseases. In asthma the receptor's activity influences inflammatory pathways likely exacerbating airway hypersensitivity. Additionally its connection with psoriasis suggests it may play a role in skin inflammation potentially linking with other inflammatory mediators like IL-17A which is significant in psoriasis pathology. Understanding P2Y10's function and interactions could help in developing new therapeutic targets for these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Putative receptor for purines coupled to G-proteins.
See full target information P2RY10
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular medicine 43:1817-1829 PubMed30816445

2019

Effects of miR‑106b‑3p on cell proliferation and epithelial‑mesenchymal transition, and targeting of ZNRF3 in esophageal squamous cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Guanen Qiao,Chenguang Dai,Yang He,Junjie Shi,Chunfang Xu
View all publications
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