Anti-P2Y10 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

P2Y10 also known as P2Y10 receptor or GPR99 is a G protein-coupled receptor (GPCR) with an approximate mass of 40 kDa. This receptor primarily binds to nucleotide ligands specifically lysophosphatidic acid (LPA). P2Y10 is expressed in a variety of tissues including the spleen lungs and liver. It plays a significant role in cellular signaling by activating downstream pathways in response to external stimuli.

Biological function summary

P2Y10 receptor functions as a modulator of immune response and cellular communication. As part of the P2Y receptor family it interacts closely with LPA to influence various physiological processes such as cell proliferation survival and migration. Despite its role in these functions the receptor does not function independently; instead it associates with other molecular complexes that help transmit signals inside the cell.

Pathways

The P2Y10 receptor influences the LPA signaling pathway which plays an important part in cellular communication and tissue homeostasis. LPA signaling involves interactions with other GPCRs and various kinases such as PI3K and MAPK. P2Y10 is interrelated with receptors like P2Y1 which share overlapping signaling cascades and contribute to similar physiological responses indicating their cooperative roles in signal transduction mechanisms.

Associated diseases and disorders

P2Y10 has associations with immune-related conditions such as asthma and inflammatory diseases. In asthma the receptor's activity influences inflammatory pathways likely exacerbating airway hypersensitivity. Additionally its connection with psoriasis suggests it may play a role in skin inflammation potentially linking with other inflammatory mediators like IL-17A which is significant in psoriasis pathology. Understanding P2Y10's function and interactions could help in developing new therapeutic targets for these conditions.