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AB180739

Anti-P2Y11 antibody

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(2 Publications)

Rabbit Polyclonal P2Y11 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human P2Y purinoceptor 11.

View Alternative Names

P2Y purinoceptor 11, P2Y11, P2RY11

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-P2Y11 antibody (AB180739)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-P2Y11 antibody (AB180739)

Immunohistochemical analysis of paraffin embedded Human lung cancer tissue labeling P2Y11 with ab180739 at 1/50 dilution.

Western blot - Anti-P2Y11 antibody (AB180739)
  • WB

Supplier Data

Western blot - Anti-P2Y11 antibody (AB180739)

All lanes:

Western blot - Anti-P2Y11 antibody (ab180739) at 1/500 dilution

Lane 1:

HeLa cell line extracts

Lane 2:

293T cell line extracts

Predicted band size: 40 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human P2Y purinoceptor 11. The exact immunogen used to generate this antibody is proprietary information.

Q96G91

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/100", "IHCP-species-notes": "<p><a href='/en-us/products/primary-antibodies/rabbit-igg-polyclonal-isotype-control-chip-grade-ab171870'>ab171870</a> - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

P2Y11 also known as P2RY11 or purinergic receptor P2Y G-protein coupled 11 is a receptor that belongs to the P2Y family of G-protein coupled receptors. This receptor is mainly involved in responding to extracellular nucleotides like ATP and UTP. The molecular mass of P2Y11 is approximately 42 kilodaltons. It is expressed in various tissues prominently in immune cells such as leukocytes and also in the heart and brain.
Biological function summary

P2Y11 acts as a critical signaling molecule influencing immune responses. It is part of the G-protein coupled receptor complex that mediates various cellular responses. Through its activation P2Y11 can regulate cytokine production which is significant for immune function. It also plays a role in modulating neurotransmitter release in the nervous system.

Pathways

Several signaling cascades involve P2Y11. The receptor is a part of the cyclic AMP (cAMP) pathway which is significant for multiple cellular functions including immunity and inflammation. P2Y11 also interacts with the MAPK/ERK pathway which affects cell division and differentiation. In these pathways it can function alongside proteins such as adenylate cyclase and phospholipase C.

P2Y11 has an association with immune-related conditions. Some research links it to conditions like autoimmunity where it might affect immune cell signaling. Additionally there is evidence of its involvement in cardiac disorders such as arrhythmias due to its expression in heart tissue. In these contexts it interacts with proteins like interleukin receptors and cardiac ion channels making it a potential target for therapeutic strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and adenylyl cyclase second messenger systems. Not activated by UTP or UDP.
See full target information P2Y purinoceptor 11
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 11:5303 PubMed33082339

2020

AKAP5 complex facilitates purinergic modulation of vascular L-type Ca channel Ca1.2.

Applications

Unspecified application

Species

Unspecified reactive species

Maria Paz Prada,Arsalan U Syed,Gopireddy R Reddy,Miguel Martín-Aragón Baudel,Víctor A Flores-Tamez,Kent C Sasse,Sean M Ward,Padmini Sirish,Nipavan Chiamvimonvat,Peter Bartels,Eamonn J Dickson,Johannes W Hell,John D Scott,Luis F Santana,Yang K Xiang,Manuel F Navedo,Madeline Nieves-Cintrón

eLife 8: PubMed30821687

2019

A G-coupled purinergic receptor boosts Ca influx and vascular contractility during diabetic hyperglycemia.

Applications

Unspecified application

Species

Unspecified reactive species

Maria Paz Prada,Arsalan U Syed,Olivia R Buonarati,Gopireddy R Reddy,Matthew A Nystoriak,Debapriya Ghosh,Sergi Simó,Daisuke Sato,Kent C Sasse,Sean M Ward,Luis F Santana,Yang K Xiang,Johannes W Hell,Madeline Nieves-Cintrón,Manuel F Navedo
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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