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AB175365

Anti-P2Y13 antibody [2H1G9]

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(1 Publication)

Mouse Monoclonal P2Y13 antibody. Suitable for Flow Cyt, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human P2RY13 aa 1-50.

View Alternative Names

GPR86, GPR94, FKSG77, P2RY13, P2Y purinoceptor 13, P2Y13, G-protein coupled receptor 86, G-protein coupled receptor 94

3 Images
Flow Cytometry - Anti-P2Y13 antibody [2H1G9] (AB175365)
  • Flow Cyt

Supplier Data

Flow Cytometry - Anti-P2Y13 antibody [2H1G9] (AB175365)

Flow cytometric analysis of HepG2 cells labeling P2Y13 using ab175365 at 1/200 dilution (green), and negative control (purple).

Western blot - Anti-P2Y13 antibody [2H1G9] (AB175365)
  • WB

Supplier Data

Western blot - Anti-P2Y13 antibody [2H1G9] (AB175365)

All lanes:

Western blot - Anti-P2Y13 antibody [2H1G9] (ab175365) at 1/500 dilution

Lane 1:

non transfected HEK293 cell lysate.

Lane 2:

P2Y13 (aa 1–49)-hIgGFc transfected HEK293 cell lysate.

Predicted band size: 28 kDa,41 kDa

false

Western blot - Anti-P2Y13 antibody [2H1G9] (AB175365)
  • WB

Supplier Data

Western blot - Anti-P2Y13 antibody [2H1G9] (AB175365)

Expected MW is 31.6 kDa

All lanes:

Western blot - Anti-P2Y13 antibody [2H1G9] (ab175365) at 1/500 dilution

All lanes:

Human P2Y13 recombinant protein

Predicted band size: 41 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

2H1G9

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

WB, Flow Cyt

applications

Immunogen

Recombinant Fragment Protein within Human P2RY13 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

Q9BPV8

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1/200 - 1/400", "FlowCyt-species-notes": "<p><a href='/en-us/products/primary-antibodies/mouse-igg1-kappa-monoclonal-15-6e10a7-isotype-control-ab170190'>ab170190</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.</p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purified from tissue culture supernatant.
Storage buffer
Preservative: 0.05% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

P2Y13 also known as P2RY13 is a G-protein coupled receptor part of the P2Y receptor family. It has a mass of approximately 42 kDa. Functionally P2Y13 recognizes extracellular nucleotides like ADP and initiates signaling cascades thereafter. This receptor is expressed in various tissues including the brain liver and immune cells. In the nervous system it plays a role in neurotransmission and might influence neuronal functions.
Biological function summary

P2Y13 participates in purinergic signaling. This pathway influences cellular responses and plays a role in multiple physiological processes. P2Y13 is not known to form part of a larger receptor complex but interacts with G-proteins to transmit signals within the cell. Its activity helps regulate lipid metabolism and influences energy homeostasis in the body.

Pathways

P2Y13 is involved in the ADP-mediated signaling pathway a critical component in the regulation of cholesterol and lipid metabolism. It interacts with proteins like G-protein subunits to activate downstream signaling pathways. In the broader context of these pathways P2Y13 supports cellular processes such as energy balance and detoxification of substances.

P2Y13 has been connected with cholesterol imbalance and related metabolic disorders. Its role in lipid homeostasis indicates it might be relevant in atherosclerosis a condition characterized by lipid accumulation in the arteries. P2Y13 also associates with neurological disorders due to its presence and role in neural tissues. It is connected to other purinergic receptors like P2Y12 in these disease contexts which collectively contribute to disease progression through dysregulated purinergic signaling.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system.
See full target information P2RY13
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell death & disease 13:425 PubMed35501353

2022

Mxi1 participates in the progression of lung cancer via the microRNA-300/KLF9/GADD34 Axis.

Applications

Unspecified application

Species

Unspecified reactive species

Yujie Lei,Yunchao Huang,Jianbin Lin,Shihui Sun,Keda Che,Junting Shen,Jun Liao,Yangming Chen,Kai Chen,Zhaoxian Lin,Xing Lin
View all publications
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Product promise

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