JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB140896

Anti-P2Y14 antibody

Be the first to review this product! Submit a review

|

(2 Publications)

Rabbit Polyclonal P2Y14 antibody. Suitable for IHC-P, ICC and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human P2RY14.

View Alternative Names

GPR105, KIAA0001, P2RY14, P2Y purinoceptor 14, P2Y14, G-protein coupled receptor 105, UDP-glucose receptor

3 Images
Immunocytochemistry - Anti-P2Y14 antibody (AB140896)
  • ICC

Unknown

Immunocytochemistry - Anti-P2Y14 antibody (AB140896)

Immunocytochemical analysis of untransfected HEK293 Human embryonic kidney cells labelling P2Y14 with ab140896 at suggested conc. of 5-10 ug/ml.

Immunocytochemistry - Anti-P2Y14 antibody (AB140896)
  • ICC

Unknown

Immunocytochemistry - Anti-P2Y14 antibody (AB140896)

Immunocytochemical analysis of HEK293 Human embryonic kidney cells transfected with P2Y14, labelling P2Y14 with ab140896 at suggested conc. of 5-10 ug/ml .

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-P2Y14 antibody (AB140896)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-P2Y14 antibody (AB140896)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain tissue labelling P2Y14 with ab140896 at 4 μg/ml (after heat-induced antigen retrieval).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC, IHC-P

applications

Immunogen

Synthetic Peptide within Human P2RY14. The exact immunogen used to generate this antibody is proprietary information.

Q15391

Specificity

BLAST analysis of the peptide immunogen showed no homology with other Human proteins.

style
left-column

Alternative Products

Primary Antibodies

AB136264

Anti-P2Y14 antibody

Western blot - Anti-P2Y14 antibody (AB136264)

  • 0
  • 0

Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB154817

Anti-UGPase antibody [EPR10627(B)]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UGPase antibody [EPR10627(B)] (AB154817)

  • 5
  • 1
Primary Antibodies

AB124879

Anti-UGGT/UGT1 antibody [EPR5105]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UGGT/UGT1 antibody [EPR5105] (AB124879)

  • 0
  • 0
Primary Antibodies

AB192876

Anti-PGM1 antibody [EPR15241]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-PGM1 antibody [EPR15241] (AB192876)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "4 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol.", "ICC-species-checked": "testedAndGuaranteed", "ICC-species-dilution-info": "5-10 µg/mL", "ICC-species-notes": "<p></p>" }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICC-species-checked": "predicted", "ICC-species-dilution-info": "", "ICC-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

P2Y14 also known as GPR105 is a G protein-coupled receptor. It has a molecular mass of approximately 40-47 kDa. P2Y14 primarily binds UDP-glucose as its ligand and plays a role in various signaling pathways. Expression of P2Y14 occurs in a variety of tissues including the immune system tissues like spleen as well as in cells such as leukocytes. It shows lower expression levels in other bodily tissues like brain and lungs.
Biological function summary

P2Y14 receptor participates in immune responses by modulating the function of various leukocytes. It does not exist as part of large multimeric complexes but interacts with the cellular machinery to influence the behavior of the immune system. Through its interaction with extracellular nucleotides and sugars P2Y14 impacts immune cell chemotaxis and cytokine release which are critical for immune regulation.

Pathways

P2Y14 receptor plays a significant role in inflammatory signaling pathways and chemotaxis. It interacts with other proteins such as P2Y12 to modulate the activation and recruitment of immune cells. P2Y14 links to key pathways such as those involving GPCR signaling impacting immune cell movement and inflammation processes.

P2Y14 has a connection to asthma and type 2 diabetes. In asthma its role in immune cell recruitment can exacerbate inflammation and contribute to symptoms. In type 2 diabetes P2Y14 influences insulin signaling potentially impacting glucose metabolism. It associates with proteins like P2X7 and P2Y12 which are involved in inflammatory processes and metabolism underlining its role in these conditions.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP, ADP, UTP or ATP.
See full target information P2RY14
style
left-column

Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in genetics 12:670746 PubMed34306014

2021

Is a Potential Biomarker of Tumor Microenvironment Immunomodulation and Favorable Prognosis in Patients With Head and Neck Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Qingxiang Li,Le Xu,Yuke Li,Rong Yang,Qiao Qiao,Yifei Wang,Lin Wang,Yuxing Guo,Chuanbin Guo

The Journal of biological chemistry : PubMed32855238

2020

Inhibitory effect of UDP-glucose on cAMP generation and insulin secretion.

Applications

Unspecified application

Species

Unspecified reactive species

Fariborz Parandeh,Stefan Amisten,Gaurav Verma,Israa Mohammed Al-Amily,Pontus Dunér,Albert Salehi
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com