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AB169392

Anti-P2Y8 antibody

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(1 Publication)

Mouse Polyclonal P2Y8 antibody. Suitable for Flow Cyt, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human P2RY8.

View Alternative Names

S-geranylgeranyl-glutathione receptor P2RY8, P2Y purinoceptor 8, P2Y8, P2RY8

1 Images
Flow Cytometry - Anti-P2Y8 antibody (AB169392)
  • Flow Cyt

Unknown

Flow Cytometry - Anti-P2Y8 antibody (AB169392)

Flow cytometric analysis of negative control 293 cells (Black) and P2Y8 expressing 293 cells (Green) using ab169392.

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, Flow Cyt

applications

Immunogen

Recombinant Full Length Protein corresponding to Human P2RY8.

Q86VZ1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1 µg/mL", "FlowCyt-species-notes": "<p><a href='/en-us/products/primary-antibodies/mouse-igg-isotype-control-ab37355'>ab37355</a> - Mouse polyclonal IgG, is suitable for use as an isotype control with this antibody.</p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The P2Y8 receptor also known as GPR99 is a member of the G protein-coupled receptors (GPCRs) family and has an approximate molecular mass of 35 kDa. It is involved in mechanical signaling by binding with extracellular nucleotides such as ATP and UTP. These interactions lead to diverse cellular responses including alterations in intracellular calcium levels. The P2Y8 receptor shows expression in a variety of tissues including the immune system suggesting its role in immune regulation.
Biological function summary

The P2Y8 receptor acts as an immune modulator and can influence the activity of leukocytes. It contributes to the regulation of inflammatory responses and potentially modulates the proliferation and migration of immune cells. While not part of a large receptor complex P2Y8 affects cellular signal transduction playing an important role in processes requiring rapid cellular responses.

Pathways

The P2Y8 receptor participates prominently in the purinergic signaling pathway. This pathway is essential for various physiological processes including inflammation thrombosis and neurotransmission. P2Y8 also interacts with other purinergic receptors and proteins such as P2Y1 and P2Y2 further establishing its role in coordinating cellular responses through nucleotide signaling.

The P2Y8 receptor is connected to inflammatory diseases where aberrant signaling may lead to excessive or prolonged inflammation. Additionally alterations or disruptions in P2Y8 function have been implicated in certain autoimmune disorders. The receptor's link with proteins such as P2Y1 and P2X7 influences its involvement in these disease pathways potentially offering targets for therapeutic intervention and contributing to our understanding of disease mechanisms.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

G protein-coupled receptor for S-geranylgeranyl-glutathione (GGG), an endogenous metabolite present in lymphoid tissues. Couples the binding of GGG to the activation of GNA13 and downstream repression of AKT activation in lymphocytes defining their positioning and growth within lymphoid organs (PubMed : 25274307, PubMed : 30842656, PubMed : 34088745). In lymphoid follicles, confines B cells and follicular helper T cells in germinal centers (GCs) in response to GGG local gradients established by GGT5 (via GGG catabolism) and ABCC1 (via extracellular transport) with lower concentrations of GGG found in the follicular dendritic cell network region around which germinal centers are formed (PubMed : 25274307, PubMed : 30842656, PubMed : 34088745). In the bone marrow, also in response to GGG gradients established by GGT5 and ABCC1, it restricts chemotactic transmigration of B cells, T cells and NK cells from blood vessels to the bone marrow parenchyma (PubMed : 30842656, PubMed : 34088745). Contributes to GNA13-dependent pathway that suppresses GC B cell growth (PubMed : 25274307).
See full target information P2RY8
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cancer research 82:3249-3262 PubMed35867033

2022

And-1 Coordinates with the FANCM Complex to Regulate Fanconi Anemia Signaling and Cisplatin Resistance.

Applications

Unspecified application

Species

Unspecified reactive species

Yi Zhang,Jing Li,Yuan Zhou,Zhuqing Li,Changmin Peng,Huadong Pei,Wenge Zhu
View all publications
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Product promise

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