JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB220675

Anti-p37 antibody

Be the first to review this product! Submit a review

|

(4 Publications)

Rabbit Polyclonal p37 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human NUP37 aa 200 to C-terminus.

View Alternative Names

Nucleoporin Nup37, p37, Nup107-160 subcomplex subunit Nup37, NUP37

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-p37 antibody (AB220675)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-p37 antibody (AB220675)

Immunofluorescent analysis of PFA-fixed, Triton X-100 permeabilized U251 MG cells labeling p37 with ab220675 at 4 μg/ml (green).

Western blot - Anti-p37 antibody (AB220675)
  • WB

Supplier Data

Western blot - Anti-p37 antibody (AB220675)

All lanes:

Western blot - Anti-p37 antibody (ab220675) at 1/100 dilution

Lane 1:

RT4 cell line lysate

Lane 2:

U251 MG cell line lysate

Lane 3:

Human plasma

Lane 4:

Human liver tissue lysate

Lane 5:

Human tonsil tissue lysate

Predicted band size: 37 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

Recombinant Fragment Protein within Human NUP37 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q8NFH4

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The p37 protein also known as the Mycoplasma pneumoniae protein has a mass of approximately 37 kDa. It functions mechanically as a surface antigen and a membrane-associated protein. Researchers express p37 in Mycoplasma species with noted presence in Mycoplasma pneumoniae and Mycoplasma genitalium. This protein facilitates the adherence of the mycoplasma to host cells an important step in infection processes. Observations reveal that p37 contains several domains that are important for its activity at the membrane surface.
Biological function summary

The p37 protein functions in the adherence of Mycoplasma pneumoniae to host epithelial cells. It plays an essential role in the initial stages of infection by facilitating bacterial attachment and colonization. p37 does not form part of a larger protein complex but interacts dynamically with several cellular components. Its ability to mediate host-pathogen interactions makes it an important element in understanding pathogenesis mechanisms of mycoplasma infections. Studies show that p37 can also interfere with host immune responses aiding bacterial survival and persistence.

Pathways

P37's involvement concerns several interaction pathways. Primarily it partakes in the processes of bacterial adhesion and pathogenesis within the host. These pathways are integral for the host-pathogen interaction and often link to cellular signaling pathways that regulate immune responses. Proteins related to these pathways include P1 adhesin another Mycoplasma pneumoniae surface protein that collaborates with p37 to promote binding to host cells. Through these interactions p37 and its related proteins collectively enhance the bacterial pathogenic potential.

The p37 protein contributes significantly to Mycoplasma pneumoniae-associated respiratory tract infections and to a lesser extent urethritis caused by Mycoplasma genitalium. These infections can result in extended periods of illness primarily when untreated. In association with respiratory infections p37 interacts with proteins such as P1 adhesin which work jointly to ensure sustainable colonization within the host. Understanding these interactions helps identify potential therapeutic targets for managing infections caused by these pathogens.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation.
See full target information NUP37
style
left-column

Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Journal of assisted reproduction and genetics 39:107-116 PubMed35022896

2022

The function of Nucleoporin 37 on mouse oocyte maturation and preimplantation embryo development.

Applications

Unspecified application

Species

Unspecified reactive species

Qianying Guo,Qiang Liu,Nan Wang,Jing Wang,Andi Sun,Jie Qiao,Liying Yan

Frontiers in oncology 11:669655 PubMed34386417

2021

Evaluation of Oncogene NUP37 as a Potential Novel Biomarker in Breast Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Kangdi Li,Ting Liu

Cell communication and signaling : CCS 17:174 PubMed31881970

2019

Deletion of low-density lipoprotein-related receptor 5 inhibits liver Cancer cell proliferation via destabilizing Nucleoporin 37.

Applications

Unspecified application

Species

Unspecified reactive species

Jinxiao Chen,Da Wo,En Ma,Hongwei Yan,Jun Peng,Weidong Zhu,Yong Fang,Dan-Ni Ren

Oncology reports 42:1125-1132 PubMed31322265

2019

Hypoxia‑induced mitochondrial translocation of DNM1L increases mitochondrial fission and triggers mPTP opening in HCC cells via activation of HK2.

Applications

Unspecified application

Species

Unspecified reactive species

Min Cai,Ping He,Dian-Liang Fang
View all publications
style
left-column
style
left-column
style
right-column

Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB9485

Anti-GAPDH antibody - Loading Control

BOND RX™ Validated|Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-GAPDH antibody - Loading Control (AB9485)

  • 5
  • 88
Primary Antibodies

AB15580

Anti-Ki67 antibody

BOND RX™ Validated|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ki67 antibody (AB15580)

  • 5
  • 230
Primary Antibodies

AB32053

Anti-Cyclin B1 antibody [Y106]

RabMAb|Recombinant|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-Cyclin B1 antibody [Y106] (AB32053)

  • 5
  • 4

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com