Anti-p38IP antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

P38-interacting protein (p38IP) functions mechanically as a scaffold protein that interacts with p38 MAPK aiding in its regulation and stabilization. It is occasionally referred to as MO25. The molecular mass of p38IP is approximately 50 kDa. Expression of p38IP is observed in various tissues with notably high levels in the brain and the heart. This distribution suggests its involvement in processes across different cell types.

Biological function summary

This protein plays a role in cellular signaling and stress responses. p38IP does not function alone; it is a component of the p38 MAPK signaling complex. By interacting with other members of this pathway such as MKK3 and MKK6 p38IP modulates cellular responses to external stressors. Its involvement in the signaling process highlights its contribution to the control of cellular dynamics under stress.

Pathways

P38IP holds significance in the MAPK signaling pathway and the JNK signaling pathway. In the MAPK signaling pathway it interfaces closely with p38 MAPK and other kinases facilitating signal transduction that impacts processes like inflammation and apoptosis. In the JNK signaling pathway interactions with JNK MAPKs suggest a role in regulating gene expression in response to stress stimuli. These pathways underline the regulatory capacity of p38IP in controlling cellular fate during stress conditions.

Associated diseases and disorders

P38IP associates with cancer progression and inflammatory disorders. Abnormal expression or malfunction of p38IP can contribute to dysregulated cell signaling in cancer partly through its relationship with p38 MAPK a known mediator of cell proliferation. In inflammatory disorders alterations in p38IP levels can affect immune response signaling also mediated through its partner JNK MAPKs illustrating its potential as a therapeutic target in these diseases.