JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB154674

Anti-p38IP antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal p38IP antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SUPT20H aa 150-450.

View Alternative Names

C13orf19, FAM48A, FP757, SUPT20H, Transcription factor SPT20 homolog, p38-interacting protein, p38IP

1 Images
Western blot - Anti-p38IP antibody (AB154674)
  • WB

Unknown

Western blot - Anti-p38IP antibody (AB154674)

7.5% SDS PAGE

All lanes:

Western blot - Anti-p38IP antibody (ab154674) at 1/1000 dilution

All lanes:

293T whole cell lysate at 30 µg

Predicted band size: 86 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human SUPT20H aa 150-450. The exact immunogen used to generate this antibody is proprietary information.

Q8NEM7

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

P38-interacting protein (p38IP) functions mechanically as a scaffold protein that interacts with p38 MAPK aiding in its regulation and stabilization. It is occasionally referred to as MO25. The molecular mass of p38IP is approximately 50 kDa. Expression of p38IP is observed in various tissues with notably high levels in the brain and the heart. This distribution suggests its involvement in processes across different cell types.
Biological function summary

This protein plays a role in cellular signaling and stress responses. p38IP does not function alone; it is a component of the p38 MAPK signaling complex. By interacting with other members of this pathway such as MKK3 and MKK6 p38IP modulates cellular responses to external stressors. Its involvement in the signaling process highlights its contribution to the control of cellular dynamics under stress.

Pathways

P38IP holds significance in the MAPK signaling pathway and the JNK signaling pathway. In the MAPK signaling pathway it interfaces closely with p38 MAPK and other kinases facilitating signal transduction that impacts processes like inflammation and apoptosis. In the JNK signaling pathway interactions with JNK MAPKs suggest a role in regulating gene expression in response to stress stimuli. These pathways underline the regulatory capacity of p38IP in controlling cellular fate during stress conditions.

P38IP associates with cancer progression and inflammatory disorders. Abnormal expression or malfunction of p38IP can contribute to dysregulated cell signaling in cancer partly through its relationship with p38 MAPK a known mediator of cell proliferation. In inflammatory disorders alterations in p38IP levels can affect immune response signaling also mediated through its partner JNK MAPKs illustrating its potential as a therapeutic target in these diseases.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy.
See full target information SUPT20H
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

American journal of translational research 14:8117-8128 PubMed36505312

2022

miR-370 impacts the biological behavior of lung cancer cells by targeting the SMAD1 signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Zhaohui Tang,Yongjun Jiang,Sijuan Ding,Shaohui Jiang,Ruoting Tang,Pengfei Luo
View all publications
style
left-column
style
left-column
style
right-column

Alternative Products

Primary Antibodies

AB122517

Anti-p38IP antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-p38IP antibody (AB122517)

  • 0
  • 0

Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB92547

Anti-Vimentin antibody [EPR3776] - Cytoskeleton Marker

BOND RX™ Validated|KO Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size|Advanced Validation

Multiplex immunohistochemistry - Anti-Vimentin antibody [EPR3776] - Cytoskeleton Marker (AB92547)

  • 5
  • 92
Primary Antibodies

AB121991

Anti-HENMT1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HENMT1 antibody (AB121991)

  • 0
  • 0
Primary Antibodies

AB121304

Anti-COL12A1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COL12A1 antibody (AB121304)

  • 3
  • 1

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com