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AB166857

Anti-p40 - DeltaNp63 antibody

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(6 Publications)

Rabbit Polyclonal P63 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human TP63 aa 1-50.

View Alternative Names

KET, P63, P73H, P73L, TP73L, TP63, Tumor protein 63, p63, Chronic ulcerative stomatitis protein, Keratinocyte transcription factor KET, Transformation-related protein 63, Tumor protein p73-like, p40, p51, CUSP, p73L

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-p40 - DeltaNp63 antibody (AB166857)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-p40 - DeltaNp63 antibody (AB166857)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human Lung squamous Cell Ca, labeling p40 - DeltaNp63 using ab166857 at a 1/50 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human TP63 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

Q9H3D4

Specificity

ab166857 recognizes deltaNp63- a p63 isoform

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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AB124762

Anti-p63 antibody [EPR5701]

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We’re constantly upgrading our range to offer the highest quality products. We have selected this alternative product for your review because it gives improved performance, is easier and more convenient to use, or is available faster.

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Properties and storage information

Form
Liquid
Purification technique
Proprietary technique
Storage buffer
pH: 7.3 - 7.5 Preservative: 0.05% Sodium azide Constituents: 98% PBS, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The biological target p40 also known as ΔNp63 is an essential protein isoform of the p63 gene. This target weighs approximately 40 kDa and is expressed predominantly in epithelial tissues such as the basal layer of the skin and select organs. Due to its significant role in development and differentiation researchers often study p40 in the context of specific cancers using techniques like p40 immunostaining p40 IHC and p40 marker assays including the anti-p40 stain.
Biological function summary

The p40 protein acts as a transcription factor regulating epithelial stem cell maintenance and differentiation. It is an integral component of the tetrameric complex of the p63 protein family where it influences the transcription of genes involved in cell cycle control and apoptotic pathways. The ΔNp63 variant lacking the N-terminal transactivation domain plays an important role in blocking premature senescence contributing to cell proliferative capacity.

Pathways

P40 is involved in the Notch signaling and the PI3K/AKT signaling pathways. In Notch signaling p40 interacts alongside related proteins like bcl-2 or B28 impacting the regulation of cell fate and differentiation. The PI3K/AKT pathway involves p40 in processes essential for cell survival and proliferation often overlapping with proteins such as AKT and mTOR.

P40 significantly links to various forms of cancer especially squamous cell carcinoma and lung adenocarcinoma. Aberrant expression of ΔNp63 and its disruption in pathways contribute to the pathogenesis of these cancers. In squamous cell carcinoma p40 expression serves as an important biomarker distinguishing it from other tumor types connecting with proteins like Bcl-2 which are important in managing apoptotic resistance in cancerous cells.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.
See full target information TP63
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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

Stem cell research & therapy 13:384 PubMed35907870

2022

Hyaluronan supports the limbal stem cell phenotype during ex vivo culture.

Applications

Unspecified application

Species

Unspecified reactive species

Sudan Puri,Isabel Y Moreno,Mingxia Sun,Sudhir Verma,Xiao Lin,Tarsis F Gesteira,Vivien J Coulson-Thomas

eLife 10: PubMed33404013

2021

The origins and consequences of variants in pancreatic adenosquamous carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Jacob T Polaski,Dylan B Udy,Luisa F Escobar-Hoyos,Gokce Askan,Steven D Leach,Andrea Ventura,Ram Kannan,Robert K Bradley

Investigative ophthalmology & visual science 61:27 PubMed32790859

2020

Epithelial Cell Migration and Proliferation Patterns During Initial Wound Closure in Normal Mice and an Experimental Model of Limbal Stem Cell Deficiency.

Applications

Unspecified application

Species

Unspecified reactive species

Sudan Puri,Mingxia Sun,Kazadi N Mutoji,Tarsis F Gesteira,Vivien J Coulson-Thomas

Genes & diseases 9:108-115 PubMed35005111

2020

Pancreatic stromal Gremlin 1 expression during pancreatic tumorigenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Joy M Davis,Binglu Cheng,Madeline M Drake,Qiang Yu,Baibing Yang,Jing Li,Chunhui Liu,Mamoun Younes,Xiurong Zhao,Jennifer M Bailey,Qiang Shen,Tien C Ko,Yanna Cao

Laboratory investigation; a journal of technical methods and pathology 100:630-642 PubMed31653968

2019

Shp2-mediated MAPK pathway regulates ΔNp63 in epithelium to promote corneal innervation and homeostasis.

Applications

Unspecified application

Species

Unspecified reactive species

Yuka Okada,Yujin Zhang,Lingling Zhang,Lung-Kun Yeh,Yen-Chiao Wang,Shizuya Saika,Chia-Yang Liu

Cellular physiology and biochemistry : internation 44:2138-2146 PubMed29241190

2017

CircRNA Expression Profile in Early-Stage Lung Adenocarcinoma Patients.

Applications

Unspecified application

Species

Unspecified reactive species

Jiangmin Zhao,Le Li,Qian Wang,Hongxiu Han,Qing Zhan,Ming Xu
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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