Rabbit Polyclonal P63 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human TP63 aa 1-50.
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- Stem cells (Dayton, Ohio) 39:1310-13212021SARS-CoV-2 infects an upper airway model derived from induced pluripotent stem cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesIvo Djidrovski,Maria Georgiou,Grant L Hughes,Edward I Patterson,Aitor Casas-Sanchez,Shaun H Pennington,Giancarlo A Biagini,Marina Moya-Molina,Jelle van den Bor,Martine J Smit,Git Chung,Majlinda Lako,Lyle ArmstrongPubMed 34152044
- Nanomedicine : nanotechnology, biology, and medicine 32:1023322020Novel nanopolymer RNA therapeutics normalize human diabetic corneal wound healing and epithelial stem cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAndrei A Kramerov,Ruchi Shah,Hui Ding,Eggehard Holler,Sue Turjman,Yaron S Rabinowitz,Sean Ghiam,Ezra Maguen,Clive N Svendsen,Mehrnoosh Saghizadeh,Julia Y Ljubimova,Alexander V LjubimovPubMed 33181273
- Head and neck pathology 14:966-9732020Metastatic HPV-Associated Oropharyngeal Versus Primary Pulmonary Squamous Cell Carcinoma: is p16 Immunostain Useful?Applications:Unspecified applicationReactive species:Unspecified reactive speciesJefree J Schulte,Jamie Steinmetz,Larissa V Furtado,Aliya N Husain,Mark W Lingen,Nicole A CiprianiPubMed 32350806
- American journal of cancer research 8:462-4752018Highly expressed histone deacetylase 5 promotes the growth of hepatocellular carcinoma cells by inhibiting the TAp63-maspin pathway.
- Scientific reports 5:133472015Ductal activation of oncogenic KRAS alone induces sarcomatoid phenotype.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYong Fu et. al.PubMed 26289340
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.09% Sodium azide
- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human TP63 aa 1-50. The exact immunogen used to generate this antibody is proprietary information. Database link Q9H3D4
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Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100 - 1/200 | Notes Perform heat-mediated antigen retrieval before commencing with IHC staining protocol. |
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Target data
Function
Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.
Alternative names
KET, P63, P73H, P73L, TP73L, TP63, Tumor protein 63, p63, Chronic ulcerative stomatitis protein, Keratinocyte transcription factor KET, Transformation-related protein 63, Tumor protein p73-like, p40, p51, CUSP, p73L
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Rabbit Polyclonal P63 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human TP63 aa 1-50.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.09% Sodium azide
- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human TP63 aa 1-50. The exact immunogen used to generate this antibody is proprietary information. Database link Q9H3D4
- Specificity
ab167612 detects a short form of Tumor protein 63 (UniProt ID Q9H3D4) - p40 - DeltaNp63.
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The biological target p40 also known as ΔNp63 is an essential protein isoform of the p63 gene. This target weighs approximately 40 kDa and is expressed predominantly in epithelial tissues such as the basal layer of the skin and select organs. Due to its significant role in development and differentiation researchers often study p40 in the context of specific cancers using techniques like p40 immunostaining p40 IHC and p40 marker assays including the anti-p40 stain.
- Biological function summary
The p40 protein acts as a transcription factor regulating epithelial stem cell maintenance and differentiation. It is an integral component of the tetrameric complex of the p63 protein family where it influences the transcription of genes involved in cell cycle control and apoptotic pathways. The ΔNp63 variant lacking the N-terminal transactivation domain plays an important role in blocking premature senescence contributing to cell proliferative capacity.
- Pathways
P40 is involved in the Notch signaling and the PI3K/AKT signaling pathways. In Notch signaling p40 interacts alongside related proteins like bcl-2 or B28 impacting the regulation of cell fate and differentiation. The PI3K/AKT pathway involves p40 in processes essential for cell survival and proliferation often overlapping with proteins such as AKT and mTOR.
- Associated diseases and disorders
P40 significantly links to various forms of cancer especially squamous cell carcinoma and lung adenocarcinoma. Aberrant expression of ΔNp63 and its disruption in pathways contribute to the pathogenesis of these cancers. In squamous cell carcinoma p40 expression serves as an important biomarker distinguishing it from other tumor types connecting with proteins like Bcl-2 which are important in managing apoptotic resistance in cancerous cells.
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Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-p40 - DeltaNp63 antibody (ab167612)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded human lung squamous cell carcinoma tissue labeling p40 - DeltaNp63 with ab167612 at 1/100 dilution.
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