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AB172731

Anti-p40 - DeltaNp63 antibody [BC28]

4

(5 Reviews)

|

(17 Publications)

Anti-p40 - DeltaNp63 antibody [BC28] (ab172731) is a mouse monoclonal antibody detecting p40 - DeltaNp63 in IHC-P. Suitable for Human.

- Over 10 publications

View Alternative Names

KET, P63, P73H, P73L, TP73L, TP63, Tumor protein 63, p63, Chronic ulcerative stomatitis protein, Keratinocyte transcription factor KET, Transformation-related protein 63, Tumor protein p73-like, p40, p51, CUSP, p73L

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-p40 - DeltaNp63 antibody [BC28] (AB172731)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-p40 - DeltaNp63 antibody [BC28] (AB172731)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of lung squamous cell carcinoma labelling p40 - DeltaNp63 with ab172731 for 30 minutes at room temperature. Counterstained with hematoxylin.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

BC28

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human TP63 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

Q9H3D4

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/100", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval via the pressure cooker method before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Product details

What is this antibody validated in?
Anti-p40 - DeltaNp63 antibody [BC28] (ab172731) is a mouse monoclonal antibody and is validated for use in Immunohistochemistry (IHC-P) in Human samples.

Trusted by the scientific community
Anti-p40 - DeltaNp63 [BC28] (ab172731) was first used in a scientific publication in 2013 and has been cited over 10 times in peer-reviewed journals.
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Properties and storage information

Form
Liquid
Purity
Tissue culture supernatant
Storage buffer
Preservative: 0.09% Sodium azide Constituents: bovine serum albumin
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Aliquoting information
Upon delivery aliquot
Storage information
Do Not Freeze
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The biological target p40 also known as ΔNp63 is an essential protein isoform of the p63 gene. This target weighs approximately 40 kDa and is expressed predominantly in epithelial tissues such as the basal layer of the skin and select organs. Due to its significant role in development and differentiation researchers often study p40 in the context of specific cancers using techniques like p40 immunostaining p40 IHC and p40 marker assays including the anti-p40 stain.
Biological function summary

The p40 protein acts as a transcription factor regulating epithelial stem cell maintenance and differentiation. It is an integral component of the tetrameric complex of the p63 protein family where it influences the transcription of genes involved in cell cycle control and apoptotic pathways. The ΔNp63 variant lacking the N-terminal transactivation domain plays an important role in blocking premature senescence contributing to cell proliferative capacity.

Pathways

P40 is involved in the Notch signaling and the PI3K/AKT signaling pathways. In Notch signaling p40 interacts alongside related proteins like bcl-2 or B28 impacting the regulation of cell fate and differentiation. The PI3K/AKT pathway involves p40 in processes essential for cell survival and proliferation often overlapping with proteins such as AKT and mTOR.

P40 significantly links to various forms of cancer especially squamous cell carcinoma and lung adenocarcinoma. Aberrant expression of ΔNp63 and its disruption in pathways contribute to the pathogenesis of these cancers. In squamous cell carcinoma p40 expression serves as an important biomarker distinguishing it from other tumor types connecting with proteins like Bcl-2 which are important in managing apoptotic resistance in cancerous cells.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.
See full target information TP63
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Publications (17)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:4369 PubMed40350470

2025

Basal-shift transformation leads to EGFR therapy-resistance in human lung adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Taro Shinozaki,Kazuhiro Togasaki,Junko Hamamoto,Akifumi Mitsuishi,Takahiro Fukushima,Kai Sugihara,Toshiki Ebisudani,Masahiko Okada,Ayaka Saito,Lisa Shigematsu,Hatsuyo Takaoka,Fumimaro Ito,Keiko Ohgino,Kota Ishioka,Kageaki Watanabe,Tsunekazu Hishima,Yutaka Kurebayashi,Katsura Emoto,Hideki Terai,Shinnosuke Ikemura,Ichiro Kawada,Keisuke Asakura,Tomoyuki Hishida,Hisao Asamura,Yuki Ohta,Sirirat Takahashi,Mayumi Oda,Megumu Saito,Mami Matano,Kenzo Soejima,Masayuki Fujii,Koichi Fukunaga,Hiroyuki Yasuda,Toshiro Sato

Thoracic cancer 16:e15488 PubMed39552203

2024

Establishing a new human lung squamous cell carcinoma cell line, OMUL-1, expressing insulin-like growth factor 1 receptor and programmed cell death ligand 1.

Applications

Unspecified application

Species

Unspecified reactive species

Hiroaki Nagamine,Masakazu Yashiro,Megumi Mizutani,Akira Sugimoto,Yoshiya Matsumoto,Yoko Tani,Hiroyasu Kaneda,Kazuhiro Yamada,Tetsuya Watanabe,Kazuhisa Asai,Satoshi Suzuki,Tomoya Kawaguchi

Journal of dairy science 106:2642-2650 PubMed36823008

2023

Cellular proliferation and apoptosis in Staphylococcus aureus-infected heifer mammary glands experiencing rapid mammary gland growth.

Applications

Unspecified application

Species

Unspecified reactive species

Pari H Baker,Kellie M Enger,Sheila K Jacobi,R Michael Akers,Benjamin D Enger

Nature communications 13:614 PubMed35105868

2022

ΔNp63 regulates a common landscape of enhancer associated genes in non-small cell lung cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Marco Napoli,Sarah J Wu,Bethanie L Gore,Hussein A Abbas,Kyubum Lee,Rahul Checker,Shilpa Dhar,Kimal Rajapakshe,Aik Choon Tan,Min Gyu Lee,Cristian Coarfa,Elsa R Flores

Neuropathology : official journal of the Japanese Society of Neuropathology 42:45-51 PubMed34933397

2021

Effectiveness of radiation therapy on brain invasion by human papillomavirus-related multiphenotypic sinonasal carcinoma: A case report.

Applications

Unspecified application

Species

Unspecified reactive species

Naoto Kuroda,Hiroshi Kawaji,Yoshifumi Arai,Yoshiro Otsuki,Katsutoshi Miura,Hiroshi Minato,Kento Kuroda,Hirokazu Nakatogawa,Tomohiro Yamazoe,Tokutaro Tanaka,Chikanori Inenaga

Immunotherapy 13:799-806 PubMed34030451

2021

Atezolizumab with bevacizumab, paclitaxel and carboplatin was effective for patients with SMARCA4-deficient thoracic sarcoma.

Applications

Unspecified application

Species

Unspecified reactive species

Hayato Kawachi,Kei Kunimasa,Yoji Kukita,Harumi Nakamura,Keiichiro Honma,Takahisa Kawamura,Takako Inoue,Motohiro Tamiya,Hanako Kuhara,Kazumi Nishino,Yu Mizote,Takashi Akazawa,Hideaki Tahara,Toru Kumagai

Laboratory investigation; a journal of technical methods and pathology 101:543-553 PubMed33495573

2021

Gene expression profiles of the original tumors influence the generation of PDX models of lung squamous cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Yunjung Kim,Aya Shiba-Ishii,Tomoki Nakagawa,Tomoyo Takeuchi,Hitomi Kawai,Ryota Matsuoka,Masayuki Noguchi,Noriaki Sakamoto

International journal of oral and maxillofacial surgery 50:163-170 PubMed32536459

2020

Elevated expression of protease-activated receptor 1 via ΔNp63 down-regulation contributes to nodal metastasis in oral squamous cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

T Hattori,S Kawano,S Tanaka,R Matsubara,T Sakamoto,Y Hashiguchi,N Kaneko,Y Mikami,M Morioka,Y Maruse,R Kitamura,E Hamada,M Hiwatashi,K Oobu,T Kiyoshima,S Nakamura

PloS one 15:e0233075 PubMed32407348

2020

Characterization of limbal explant sites: Optimization of stem cell outgrowth in in vitro culture.

Applications

Unspecified application

Species

Unspecified reactive species

Pattama Ekpo,Naharuthai Inthasin,Sutthicha Matamnan,Patimaporn Wongprompitak,Methichit Wattanapanitch,Chawikan Boonwong,Chareenun Chirapapaisan,Panotsom Ngowyutagon,Mongkol Uiprasertkul,Pinnita Prabhasawat,Wiwit Tantibhedhyangkul

Journal of cancer research and clinical oncology 145:2495-2506 PubMed31494736

2019

Validity of using immunohistochemistry to predict treatment outcome in patients with non-small cell lung cancer not otherwise specified.

Applications

Unspecified application

Species

Unspecified reactive species

Takahiro Ota,Keisuke Kirita,Reiko Matsuzawa,Hibiki Udagawa,Shingo Matsumoto,Kiyotaka Yoh,Seiji Niho,Genichiro Ishii,Koichi Goto
View all publications
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