Anti-p53 BP3 antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

Alongside being associated with cell cycle checkpoints p53 BP3 participates in DNA damage response and repair processes. It works in close association with proteins like BRCA2 and p21 potentially forming part of a complex that ensures genomic stability and assists in cell cycle arrest in response to DNA damage. Through these interactions p53 BP3 contributes to the effective management and repair of DNA lesions supporting the orderly progression through the cell cycle.

Pathways

Cell cycle and DNA damage response pathways both involve p53 BP3. In the p53 signaling pathway it interacts with p53 which coordinates cell cycle arrest and DNA repair. In the DNA damage response pathway BRCA2 and p21 are closely linked to p53 BP3 facilitating homologous recombination and checkpoint control. p53 BP3’s role here ensures proper cellular responses to prevent mutations from being passed on during cell division.