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AB67206

Anti-p60 katanin antibody

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(1 Publication)

Mouse Polyclonal p60 katanin antibody. Carrier free. Suitable for WB and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human KATNA1.

View Alternative Names

Katanin p60 ATPase-containing subunit A1, Katanin p60 subunit A1, p60 katanin, KATNA1

2 Images
Western blot - Anti-p60 katanin antibody (AB67206)
  • WB

Unknown

Western blot - Anti-p60 katanin antibody (AB67206)

p60 katanin expression in NIH/3T3.

All lanes:

Western blot - Anti-p60 katanin antibody (ab67206)

Predicted band size: 56 kDa

Observed band size: 56 kDa

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Western blot - Anti-p60 katanin antibody (AB67206)
  • WB

Unknown

Western blot - Anti-p60 katanin antibody (AB67206)

All lanes:

Western blot - Anti-p60 katanin antibody (ab67206)

Lane 1:

p60 katanin transfected 293T cell lysate

Lane 2:

Non transfected 293T cell lysate

Predicted band size: 56 kDa

Observed band size: 34 kDa

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Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Mouse, Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human KATNA1.

O75449

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

P60 katanin sometimes called katanin-p60 or KATNA1 is an important protein involved in microtubule severing. The protein has a molecular mass of approximately 60 kDa. It is expressed in various tissues with a high presence in the nervous system. Mechanically p60 katanin disrupts microtubules by hydrolyzing ATP which results in microtubule fragmentation. This activity requires the proper interaction of its two subunits p60 and p80 to execute its full function.
Biological function summary

P60 katanin plays a significant role in cellular processes such as mitosis where it regulates microtubule dynamics. It is part of a larger complex that includes the regulatory subunit p80 katanin which assists in targeting and anchoring. p60 katanin's activity influences the organization of the microtubule network which is vital for intracellular transport and cell division especially in neurons where it affects axon growth and pruning.

Pathways

P60 katanin is involved in the mitotic and neuronal development pathways. It interacts with proteins like spastin and katanin-like proteins within these pathways. In the mitotic pathway it facilitates chromosome segregation and mitotic spindle organization. During neuronal development its microtubule-severing action contributes to remodeling the cytoskeleton therefore aiding in neuron differentiation and migration.

Abnormal p60 katanin activity links to neurological conditions such as Alzheimer's disease and spastic paraplegia. Mutations or dysregulation in p60 katanin or its pathway associates can lead to impaired microtubule dynamics influencing these diseases. In spastic paraplegia p60 katanin's interaction with spastin is particularly notable as both proteins are involved in microtubule maintenance and defects in either can contribute to the disease pathology.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
See full target information KATNA1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Disease models & mechanisms 3:743-51 PubMed20829563

2010

Genetic and chemical modulation of spastin-dependent axon outgrowth in zebrafish embryos indicates a role for impaired microtubule dynamics in hereditary spastic paraplegia.

Applications

WB

Species

Zebrafish

Richard Butler,Jonathan D Wood,Jennifer A Landers,Vincent T Cunliffe
View all publications
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Product promise

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