Anti-p60 katanin antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

P60 katanin sometimes called katanin-p60 or KATNA1 is an important protein involved in microtubule severing. The protein has a molecular mass of approximately 60 kDa. It is expressed in various tissues with a high presence in the nervous system. Mechanically p60 katanin disrupts microtubules by hydrolyzing ATP which results in microtubule fragmentation. This activity requires the proper interaction of its two subunits p60 and p80 to execute its full function.

Biological function summary

P60 katanin plays a significant role in cellular processes such as mitosis where it regulates microtubule dynamics. It is part of a larger complex that includes the regulatory subunit p80 katanin which assists in targeting and anchoring. p60 katanin's activity influences the organization of the microtubule network which is vital for intracellular transport and cell division especially in neurons where it affects axon growth and pruning.

Pathways

P60 katanin is involved in the mitotic and neuronal development pathways. It interacts with proteins like spastin and katanin-like proteins within these pathways. In the mitotic pathway it facilitates chromosome segregation and mitotic spindle organization. During neuronal development its microtubule-severing action contributes to remodeling the cytoskeleton therefore aiding in neuron differentiation and migration.

Associated diseases and disorders

Abnormal p60 katanin activity links to neurological conditions such as Alzheimer's disease and spastic paraplegia. Mutations or dysregulation in p60 katanin or its pathway associates can lead to impaired microtubule dynamics influencing these diseases. In spastic paraplegia p60 katanin's interaction with spastin is particularly notable as both proteins are involved in microtubule maintenance and defects in either can contribute to the disease pathology.