JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB137797

Anti-p73 antibody

Be the first to review this product! Submit a review

|

(5 Publications)

Rabbit Polyclonal P73 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TP73 aa 1-450.

View Alternative Names

P73, TP73, Tumor protein p73, p53-like transcription factor, p53-related protein

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-p73 antibody (AB137797)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-p73 antibody (AB137797)

Immunofluorescence analysis of paraformaldehyde-fixed HeLa cells labelling p73 with ab137797 at 1/100 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-p73 antibody (AB137797)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-p73 antibody (AB137797)

Immunohistochemical analysis of paraffin-embedded Human Cal27 xenograft tissue labelling p73 with ab137797 at 1/100 dilution.

Western blot - Anti-p73 antibody (AB137797)
  • WB

Unknown

Western blot - Anti-p73 antibody (AB137797)

All lanes:

Western blot - Anti-p73 antibody (ab137797) at 1/1000 dilution

All lanes:

Jurkat whole cell lysate at 30 µg

Predicted band size: 69 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human TP73 aa 1-450. The exact immunogen used to generate this antibody is proprietary information.

O15350

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/1000", "ICCIF-species-notes": "<p></p>" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein p73 also known in scientific literature as p-73 or simply p 73 is a member of the p53 family of transcription factors. Molecular weight of p73 is approximately 80 kDa. It is expressed widely in human tissues with high levels observed in the brain kidneys and heart. Structurally p73 is similar to p53 and shares many functional domains including a DNA-binding domain and an oligomerization domain.
Biological function summary

P73 plays a significant role in regulating cell cycle and apoptosis. It can activate transcription of several genes involved in these processes. p73 does not function alone; it can form complexes with other p53 family members and modulate cellular responses to stress. p73 also contributes to differentiation particularly in neuronal cells where it promotes survival and development.

Pathways

The activity of p73 is involved in important signaling routes such as the DNA damage response and the apoptosis pathway. It interacts with many other proteins including p53 to maintain genomic stability. The pathway connections illustrate that p73 acts as a critical node influencing cell fate and maintaining cellular health.

Research links p73 to conditions such as cancer and neurodevelopmental disorders. Abnormal expression or mutation of p73 is observed in various cancers often associated with altered p53 function. In neurodevelopmental disorders deficits in p73 expression can impair brain development and function. Understanding how p73 interacts with p53 in these contexts is important for developing therapeutic strategies.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. Is an activator of FOXJ1 expression (By similarity). It is an essential factor for the positive regulation of lung ciliated cell differentiation (PubMed : 34077761).
See full target information TP73
style
left-column

Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Aging 15:13558-13578 PubMed38016120

2023

Lnc-PTCHD4-AS inhibits gastric cancer through MSH2-MSH6 dimerization and ATM-p53-p21 activation.

Applications

Unspecified application

Species

Unspecified reactive species

Jingyun Wang,Yang Mi,Xiangdong Sun,Xia Xue,Huanjie Zhao,Mengfei Zhang,Baitong Hu,Ihtisham Bukhari,Pengyuan Zheng

Molecular cancer 20:70 PubMed33874956

2021

CircLIFR synergizes with MSH2 to attenuate chemoresistance via MutSα/ATM-p73 axis in bladder cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Hui Zhang,Xingyuan Xiao,Wenjie Wei,Chao Huang,Miao Wang,Liang Wang,Yuanqiao He,Jiayin Sun,Yangkai Jiang,Guosong Jiang,Xiaoping Zhang

eLife 9: PubMed33063669

2020

Secondary ossification center induces and protects growth plate structure.

Applications

Unspecified application

Species

Unspecified reactive species

Meng Xie,Pavel Gol'din,Anna Nele Herdina,Jordi Estefa,Ekaterina V Medvedeva,Lei Li,Phillip T Newton,Svetlana Kotova,Boris Shavkuta,Aditya Saxena,Lauren T Shumate,Brian D Metscher,Karl Großschmidt,Shigeki Nishimori,Anastasia Akovantseva,Anna P Usanova,Anastasiia D Kurenkova,Anoop Kumar,Irene Linares Arregui,Paul Tafforeau,Kaj Fried,Mattias Carlström,András Simon,Christian Gasser,Henry M Kronenberg,Murat Bastepe,Kimberly L Cooper,Peter Timashev,Sophie Sanchez,Igor Adameyko,Anders Eriksson,Andrei S Chagin

The Journal of biological chemistry 293:19546-19558 PubMed30429221

2018

Cytoplasmic pro-apoptotic function of the tumor suppressor p73 is mediated through a modified mode of recognition of the anti-apoptotic regulator Bcl-X.

Applications

Unspecified application

Species

Unspecified reactive species

Mi-Kyung Yoon,Bu-Yeon Kim,Ji-Young Lee,Ji-Hyang Ha,Sung Ah Kim,Dong-Hwa Lee,Min-Sung Lee,Mi-Kyung Lee,Jin Sun Choi,Jin Hwa Cho,Jeong-Hoon Kim,Sunhong Kim,Jaewhan Song,Sung Goo Park,Byoung Chul Park,Kwang-Hee Bae,Sang Un Choi,Seung-Wook Chi

Molecular medicine reports 12:4620-4625 PubMed26126921

2015

Zoledronic acid inhibits the pentose phosphate pathway through attenuating the Ras-TAp73-G6PD axis in bladder cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaolin Wang,Guang Wu,Guangxin Cao,Lei Yang,Haifei Xu,Jian Huang,Jianquan Hou
View all publications
style
left-column
style
left-column
style
right-column

Alternative Products

Primary Antibodies

AB189896

Anti-p73 antibody [EPR18409(T)(MIX)]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-p73 antibody [EPR18409(T)(MIX)] (AB189896)

  • 4
  • 3
Primary Antibodies

AB197039

Alexa Fluor® 647 Anti-p73 antibody [EP436Y]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Alexa Fluor® 647 Anti-p73 antibody [EP436Y] (AB197039)

  • 0
  • 0
Primary Antibodies

AB215038

Anti-p73 antibody [EPR19884] - ChIP Grade

RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-p73 antibody [EPR19884] - ChIP Grade (AB215038)

  • 0
  • 0
Primary Antibodies

AB202474

Anti-p73 antibody [EPR19560] - ChIP Grade

RabMAb|Recombinant|KO Validated

ChIP - Anti-p73 antibody [EPR19560] - ChIP Grade (AB202474)

  • 0
  • 0
Primary Antibodies

AB218625

Anti-p73 (phospho Y99) antibody [EPR21751]

RabMAb|Recombinant|Trial Size

Immunoprecipitation - Anti-p73 (phospho Y99) antibody [EPR21751] (AB218625)

  • 0
  • 0
Primary Antibodies

AB40658

Anti-p73 antibody [EP436Y]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-p73 antibody [EP436Y] (AB40658)

  • 4
  • 2

Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB15580

Anti-Ki67 antibody

BOND RX™ Validated|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ki67 antibody (AB15580)

  • 5
  • 230
Primary Antibodies

AB8227

Anti-beta Actin antibody - Loading Control

BOND RX™ Validated|Lab Essentials

Western blot - Anti-beta Actin antibody - Loading Control (AB8227)

  • 5
  • 104
Primary Antibodies

AB26

Anti-p53 antibody [PAb 240]

KO Validated|Lab Essentials

Western blot - Anti-p53 antibody [PAb 240] (AB26)

  • 4
  • 56

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com