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Rabbit Polyclonal PABPC1L antibody. Suitable for WB, IHC-P and reacts with Rat, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PABPC1L aa 500 to C-terminus.

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Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PABPC1L antibody (AB233280), expandable thumbnail
  • Western blot - Anti-PABPC1L antibody (AB233280), expandable thumbnail
  • Western blot - Anti-PABPC1L antibody (AB233280), expandable thumbnail

Publications

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7.4
Preservative: 0.011% Proclin 300
Constituents: 55.77% Glycerol (glycerin, glycerine), 44.219% PBS

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human PABPC1L aa 500 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q4VXU2

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WBIHC-P
Human
Tested
Tested
Rat
Tested
Expected

Tested
Tested

Species

Rat

Dilution info

0.2-2 µg/mL

Notes

-

Species

Human

Dilution info

0.2-2 µg/mL

Notes

-

Tested
Tested

Species

Human

Dilution info

5-20 µg/mL

Notes

-

Expected
Expected

Species

Rat

Dilution info

Use at an assay dependent concentration.

Notes

-

Alternative names

Recommended products

Rabbit Polyclonal PABPC1L antibody. Suitable for WB, IHC-P and reacts with Rat, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PABPC1L aa 500 to C-terminus.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Recombinant Fragment Protein within Human PABPC1L aa 500 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q4VXU2
Purification technique

Affinity purification Protein A

Concentration
Loading...
Purification notes

ab233280 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography.

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

PABPC1L also known as cytoplasmic poly(A)-binding protein 1-like is a protein encoded by the PABPC1L gene. It weighs approximately 72 kDa. This protein binds to the poly(A) tail of mRNA molecules facilitating the regulation of mRNA stability and translation. PABPC1L shows expression in various tissues with notable expression in testis and oocytes where it functions during gametogenesis.

Biological function summary

PABPC1L influences mRNA metabolic processes and is important during oocyte maturation and early embryogenesis. It acts as a regulator of mRNA decay and translation control most likely as part of larger ribonucleoprotein complexes. By connecting with other RNA-binding proteins PABPC1L helps modulate translational control during the transition from a quiescent oocyte to an activated embryo facilitating proper development stages.

Pathways

PABPC1L participates in mRNA surveillance and translational control. It notably operates in pathways like the mRNA decay pathway where it works closely with other proteins including eukaryotic initiation factors. PABPC1L interacts with such factors to fine-tune the balance between mRNA translation and degradation impacting protein synthesis in embryonic cells.

Associated diseases and disorders

PABPC1L has connections with reproductive and developmental conditions. Aberrant expression may link to impaired gamete formation and fertility issues. Its association with other RNA-binding proteins reinforces connections to reproductive disorders. Additionally PABPC1L's role in early embryonic development suggests potential links to embryogenesis disorders where proper mRNA regulation is critical.

Product promise

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In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
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3 product images

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PABPC1L antibody (ab233280), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PABPC1L antibody (ab233280)

    Formalin-fixed, paraffin-embedded human liver tissue stained for PABPC1L using ab233280 at 20 μg/ml in immunohistochemical analysis. DAB staining.

  • Western blot - Anti-PABPC1L antibody (ab233280), expandable thumbnail

    Western blot - Anti-PABPC1L antibody (ab233280)

    All lanes: Western blot - Anti-PABPC1L antibody (ab233280) at 2 µg/mL

    All lanes: Rat liver lysate

    Secondary

    All lanes: HRP-Linked Goat Anti-Rabbit IgG Polyclonal at 0.2 µg/mL

    Predicted band size: 68 kDa

  • Western blot - Anti-PABPC1L antibody (ab233280), expandable thumbnail

    Western blot - Anti-PABPC1L antibody (ab233280)

    All lanes: Western blot - Anti-PABPC1L antibody (ab233280) at 2 µg/mL

    All lanes: Recombinant human PABPC1L protein

    Predicted band size: 68 kDa

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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