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AB233280

Anti-PABPC1L antibody

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(3 Publications)

Rabbit Polyclonal PABPC1L antibody. Suitable for WB, IHC-P and reacts with Rat, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PABPC1L aa 500 to C-terminus.

View Alternative Names

C20orf119, PABPC1L, Polyadenylate-binding protein 1-like

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PABPC1L antibody (AB233280)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PABPC1L antibody (AB233280)

Formalin-fixed, paraffin-embedded human liver tissue stained for PABPC1L using ab233280 at 20 μg/ml in immunohistochemical analysis. DAB staining.

Western blot - Anti-PABPC1L antibody (AB233280)
  • WB

Supplier Data

Western blot - Anti-PABPC1L antibody (AB233280)

All lanes:

Western blot - Anti-PABPC1L antibody (ab233280) at 2 µg/mL

All lanes:

Rat liver lysate

Secondary

All lanes:

HRP-Linked Goat Anti-Rabbit IgG Polyclonal at 0.2 µg/mL

Predicted band size: 68 kDa

false

Western blot - Anti-PABPC1L antibody (AB233280)
  • WB

Supplier Data

Western blot - Anti-PABPC1L antibody (AB233280)

All lanes:

Western blot - Anti-PABPC1L antibody (ab233280) at 2 µg/mL

All lanes:

Recombinant human PABPC1L protein

Predicted band size: 68 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human PABPC1L aa 500 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q4VXU2

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Purification notes
ab233280 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography.
Storage buffer
pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PABPC1L also known as cytoplasmic poly(A)-binding protein 1-like is a protein encoded by the PABPC1L gene. It weighs approximately 72 kDa. This protein binds to the poly(A) tail of mRNA molecules facilitating the regulation of mRNA stability and translation. PABPC1L shows expression in various tissues with notable expression in testis and oocytes where it functions during gametogenesis.
Biological function summary

PABPC1L influences mRNA metabolic processes and is important during oocyte maturation and early embryogenesis. It acts as a regulator of mRNA decay and translation control most likely as part of larger ribonucleoprotein complexes. By connecting with other RNA-binding proteins PABPC1L helps modulate translational control during the transition from a quiescent oocyte to an activated embryo facilitating proper development stages.

Pathways

PABPC1L participates in mRNA surveillance and translational control. It notably operates in pathways like the mRNA decay pathway where it works closely with other proteins including eukaryotic initiation factors. PABPC1L interacts with such factors to fine-tune the balance between mRNA translation and degradation impacting protein synthesis in embryonic cells.

PABPC1L has connections with reproductive and developmental conditions. Aberrant expression may link to impaired gamete formation and fertility issues. Its association with other RNA-binding proteins reinforces connections to reproductive disorders. Additionally PABPC1L's role in early embryonic development suggests potential links to embryogenesis disorders where proper mRNA regulation is critical.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information PABPC1L
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Cancer research 84:1659-1679 PubMed38382068

2024

PABPC1L Induces IDO1 to Promote Tryptophan Metabolism and Immune Suppression in Renal Cell Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Guannan Shu,Minyu Chen,Wuyuan Liao,Liangmin Fu,Mingjie Lin,Chengpeng Gui,Junjie Cen,Jun Lu,Zhenhua Chen,Jinhuan Wei,Wei Chen,Yinghan Wang,Jiangquan Zhu,Tianxin Zhao,Xiaonan Liu,Jiajia Jing,Guo-Chang Liu,Yihui Pan,Junhang Luo,Jiaxing Zhang

Open medicine (Warsaw, Poland) 16:805-815 PubMed34027108

2021

Functional implications of PABPC1 in the development of ovarian cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Cong Feng,Yan-Hua Han,Na Qi,Jia Li,Qing-Hua Sheng,Yu Liu,Li-Li Yang

Oncology letters 17:3439-3445 PubMed30867782

2019

PABPC1L depletion inhibits proliferation and migration via blockage of AKT pathway in human colorectal cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yue-Qin Wu,Chao-Long Ju,Bao-Juan Wang,Ruo-Gu Wang
View all publications
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