Anti-PAC-2 antibody [EPR9947(2)]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

PAC-2 also known as PAC and Anti-PAC is a protein involved in various cellular processes. It appears important in apoptosis and the regulation of cellular proliferation. PAC-2 has an approximate mass of 40 kDa. Researchers have observed its expression in different tissues including the nervous system immune cells and several cancerous tissues. Understanding the mechanical functions of PAC-2 can offer insights into its role in cellular homeostasis and disease pathology.

Biological function summary

PAC-2 plays an essential role in apoptosis acting as a mediator of programmed cell death. While not characterized as part of a larger complex PAC-2 interacts with other proteins to regulate cell survival and death. It likely influences the mitochondrial pathway of apoptosis by controlling cytochrome c release which is a critical step in the activation of caspases. These interactions emphasize the protein's adaptive importance in various biological contexts.

Pathways

PAC-2 commands a significant presence in apoptotic signaling and cellular stress response pathways. It influences the intrinsic (mitochondrial) apoptotic pathway and may interact with proteins such as Bcl-2 family members and caspase-9. This interaction places PAC-2 in an important position where it can modify the balance between cell survival and cell death involving proteins that balance pro-apoptotic and anti-apoptotic signals.

Associated diseases and disorders

PAC-2 has correlations with cancer and neurodegenerative diseases. Its dysregulation in certain cancers suggests a role in tumor progression and resistance to apoptosis. The connection to Bcl-2 highlights this aspect as both are involved in the suppression of cell death. In neurodegenerative diseases like Alzheimer's altered PAC-2 function might contribute to the pathological accumulation of damaged cells influenced by its effect on apoptotic pathways. Understanding these links could advance therapeutic strategies for related conditions.