AB28670

Anti-PACAP receptor/ADCYAP1R1 antibody

Name: Anti-PACAP receptor/ADCYAP1R1 antibody (ab28670) | Abcam
Brand: Abcam Limited
SKU: AB28670
Rating: 3 (1 reviews)

(1 Review)

(9 Publications)

Rabbit Polyclonal PACAP receptor/ADCYAP1R1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 9 publications. Immunogen corresponding to Synthetic Peptide within Human Pituitary adenylate cyclase-activating polypeptide type I receptor conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

Pituitary adenylate cyclase-activating polypeptide type I receptor, PAC1 receptor, PAC1R, PACAP type I receptor, PACAP-R-1, PACAP-R1, ADCYAP1R1

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PACAP receptor/ADCYAP1R1 antibody (AB28670)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PACAP receptor/ADCYAP1R1 antibody (AB28670)

ab28670 staining Human PACAP receptor/ADCYAP1R1 in human myenteric ganglia cells of the small intestine by immunohistochemistry using paraffin embedded tissue.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human Pituitary adenylate cyclase-activating polypeptide type I receptor conjugated to Keyhole Limpet Haemocyanin.

P41586

style

left-column

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

style

left-column

style

left-column

Properties and storage information

Form

Liquid

Purity

Whole antiserum

Storage buffer

Preservative: 0.05% Sodium azide Constituents: Whole serum

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

style

left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The PACAP receptor also known as ADCYAP1R1 is a G-protein-coupled receptor that interacts with the neuropeptide PACAP (Pituitary Adenylate Cyclase-Activating Polypeptide). This receptor plays a role in transmitting extracellular signals into cellular responses. It is comprised of approximately 525 amino acids with a considerable molecular mass of around 59 kDa. The PACAP receptors are widely expressed in the central nervous system including regions like the hypothalamus hippocampus and cerebellum. It also appears in peripheral tissues such as the adrenal glands and testis.

Biological function summary

PACAP receptor plays significant roles in both neuronal and endocrine systems. It modulates neurotransmitter release and affects neurotrophic activities. The receptor often operates in a receptor-ligand complex with PACAP which enables it to participate in neuroprotective and neurite outgrowth functions. This receptor actively regulates activities within the hypothalamic-pituitary-adrenal axis impacting stress responses and circadian rhythms.

Pathways

Many processes involve the PACAP receptor through essential signaling pathways like the cAMP-PKA and MAPK pathways. These pathways integrate signals from multiple receptor types including glucocorticoid receptors. The PACAP receptor often interacts with other adenylyl cyclase-activating proteins enhancing its involvement in neural cAMP synthesis and related functions. This places the receptor within key pathways regulating brain development and neuroplasticity.

The PACAP receptor holds connections to both mental health and neurological conditions. Its abnormal function has associations with disorders such as anxiety-related disorders and migraine. The receptor's relationship with proteins like the CRH (Corticotropin-Releasing Hormone) receptor further implicates its role in the pathophysiology of stress-induced disorders. Targeting PACAP receptors can thereby offer therapeutic potential in the management of these conditions.

style

left-column

style

left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

Target data

G protein-coupled receptor activated by the neuropeptide pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) (PubMed : 32047270, PubMed : 33715378, PubMed : 35477937, PubMed : 36385145). Binds both PACAP27 and PACAP38 bioactive peptides (PubMed : 32047270, PubMed : 35477937, PubMed : 36385145). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway (PubMed : 32047270, PubMed : 33715378, PubMed : 35477937, PubMed : 36385145). May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract (PubMed : 32047270, PubMed : 33715378).

See full target information Pituitary adenylate cyclase-activating polypeptide type I receptor

style

left-column

Publications (9)

Recent publications for all applications. Explore the full list and refine your search

Acta pharmacologica Sinica 44:2418-2431 PubMed37563446

2023

PACAP/PAC1-R activation contributes to hyperalgesia in 6-OHDA-induced Parkinson's disease model rats via promoting excitatory synaptic transmission of spinal dorsal horn neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Li-Guo Dong,Meng-Qi An,Han-Ying Gu,Li-Ge Zhang,Jin-Bao Zhang,Cheng-Jie Li,Cheng-Jie Mao,Fen Wang,Chun-Feng Liu

The journal of headache and pain 24:66 PubMed37271806

2023

PACAP6-38 improves nitroglycerin-induced central sensitization by modulating synaptic plasticity at the trigeminal nucleus caudalis in a male rat model of chronic migraine.

Applications

Unspecified application

Species

Unspecified reactive species

Lily Zhang,Yanjie Zhou,Liu Yang,Yue Wang,Zheman Xiao

International journal of molecular sciences 23: PubMed36555637

2022

Novel Small Molecule Positive Allosteric Modulator SPAM1 Triggers the Nuclear Translocation of PAC1-R to Exert Neuroprotective Effects through Neuron-Restrictive Silencer Factor.

Applications

Unspecified application

Species

Unspecified reactive species

Guangchun Fan,Shang Chen,Lili Liang,Huahua Zhang,Rongjie Yu

Acta biochimica et biophysica Sinica 54:1349-1364 PubMed36082935

2022

A novel small positive allosteric modulator of neuropeptide receptor PAC1-R exerts neuroprotective effects in MPTP mouse Parkinson's disease model.

Applications

Unspecified application

Species

Unspecified reactive species

Guangchun Fan,Shang Chen,Zhengxin Tao,Huahua Zhang,Rongjie Yu

Acta biochimica et biophysica Sinica 54:657-672 PubMed35593471

2022

Positive allosteric regulation of PAC1-R up-regulates PAC1-R and its specific ligand PACAP.

Applications

Unspecified application

Species

Unspecified reactive species

Guangchun Fan,Zhengxin Tao,Shang Chen,Huahua Zhang,Rongjie Yu

PloS one 14:e0218279 PubMed31194824

2019

ZEB1 insufficiency causes corneal endothelial cell state transition and altered cellular processing.

Applications

Unspecified application

Species

Unspecified reactive species

Ricardo F Frausto,Doug D Chung,Payton M Boere,Vinay S Swamy,Huong N V Duong,Liyo Kao,Rustam Azimov,Wenlin Zhang,Liam Carrigan,Davey Wong,Marco Morselli,Marina Zakharevich,E Maryam Hanser,Austin C Kassels,Ira Kurtz,Matteo Pellegrini,Anthony J Aldave

Neuroscience 393:319-332 PubMed30336190

2018

Expression of Pituitary Adenylate Cyclase-activating Peptide, Calcitonin Gene-related Peptide and Headache Targets in the Trigeminal Ganglia of Rats and Humans.

Applications

Unspecified application

Species

Unspecified reactive species

Simona Denise Frederiksen,Karin Warfvinge,Lena Ohlsson,Lars Edvinsson

Cephalalgia : an international journal of headache 37:1350-1372 PubMed27852962

2016

Anatomy and immunochemical characterization of the non-arterial peptidergic diffuse dural innervation of the rat and Rhesus monkey: Implications for functional regulation and treatment in migraine.

Applications

Unspecified application

Species

Unspecified reactive species

Frank L Rice,Jennifer Y Xie,Phillip J Albrecht,Emily Acker,Justin Bourgeois,Edita Navratilova,David W Dodick,Frank Porreca

Journal of drug targeting 18:457-67 PubMed20050817

2010

VPAC receptor mediated tumor cell targeting by protamine based nanoparticles.

Applications

ICC

Species

Human

Anna Ortner,Karin Wernig,Raphaela Kaisler,Michael Edetsberger,Franz Hajos,Gottfried Köhler,Wilhelm Mosgoeller,Andreas Zimmer

View all publications

style

left-column

style

left-column

style

right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-PACAP receptor/ADCYAP1R1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PACAP receptor/ADCYAP1R1 antibody (AB28670)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Complementary Products

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purity

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (9)

Product promise