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AB110144

Anti-PACE4 antibody

4

(1 Review)

|

(1 Publication)

Goat Polyclonal PACE4 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human PCSK6 aa 800-850.

View Alternative Names

PACE4, PCSK6, Proprotein convertase subtilisin/kexin type 6, Paired basic amino acid cleaving enzyme 4, Subtilisin-like proprotein convertase 4, Subtilisin/kexin-like protease PACE4, SPC4

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PACE4 antibody (AB110144)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PACE4 antibody (AB110144)

ab110144, at 3.75 μg/ml, staining PACE4 in formalin fixed, paraffin embedded Human testis by Immunohistochemistry.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PACE4 antibody (AB110144)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PACE4 antibody (AB110144)

ab110144, at 3.75 μg/ml, staining PACE4 in formalin fixed, paraffin embedded Human skeletal muscle by Immunohistochemistry.

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human PCSK6 aa 800-850. The exact immunogen used to generate this antibody is proprietary information.

P29122

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Alternative Products

Primary Antibodies

AB140934

Anti-PACE4 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PACE4 antibody (AB140934)

  • 0
  • 1

Complementary Products

Proteins & Peptides

AB114961

Recombinant Human PACE4 protein

SDS-PAGE - Recombinant Human PACE4 protein (AB114961)

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  • 0
Primary Antibodies

AB242123

Anti-Factor XII antibody [EPR22292-127]

RabMAb|Recombinant|Trial Size

Western blot - Anti-Factor XII antibody [EPR22292-127] (AB242123)

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  • 0
Secondary Antibodies

AB150129

Donkey Anti-Goat IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Donkey Anti-Goat IgG H&L (Alexa Fluor® 488) (AB150129)

  • 5
  • 6
Primary Antibodies

AB254715

Anti-ZNF503 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF503 antibody (AB254715)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "3.75 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: Tris buffered saline, 0.5% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PACE4 also known as PCSK6 is a member of the proprotein convertase family that functions mechanically as a serine endoprotease. This protein plays a role in cleaving precursors of hormones and other proteins to activate their bioactive forms. PACE4 has a molecular mass of approximately 97 kDa. It is expressed in various tissues including the brain pituitary gland and reproductive organs indicative of its involvement in diverse physiological processes.
Biological function summary

PACE4 participates in cellular and developmental processes by processing precursors into active proteins. It is part of a complex of proprotein convertases responsible for the maturation of secretory pathway proteins. PACE4 takes part in the regulation of growth factors matrix metalloproteinases and adhesion molecules exerting influence on cellular growth and development as well as extracellular matrix remodeling.

Pathways

PACE4 involves itself in specific signaling pathways integral to the activation of precursor proteins. It prominently participates in the TGF-beta signaling pathway where it activates transforming growth factor-beta precursors. PACE4 also acts in pathways implicated in the release of active forms of proteins such as integrins and collagens working alongside related convertases such as furin which shares overlapping substrate specificity.

PACE4 contribution links to pathological processes in certain cancers and osteoarthritis through its regulation of tumor growth and cartilage degradation respectively. In cancer PACE4 activates matrix metalloproteinases that aid tumor invasion and metastasis. Its relation with cancer involves interactions with other proteins like MMP-2 enhancing the potential for cellular invasiveness. In osteoarthritis PACE4's influence on cartilage tissue involves connections with ADAMTSs impacting cartilage matrix composition and health.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues.
See full target information PCSK6
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cellular physiology and biochemistry : internation 48:2318-2336 PubMed30114709

2018

Metabolic Shift Induced by ω -3 PUFAs and Rapamycin Lead to Cancer Cell Death.

Applications

Unspecified application

Species

Unspecified reactive species

Shenglong Zhu,Ninghan Feng,Guangxiao Lin,Yuelin Tong,Xuan Jiang,Qin Yang,Shunhe Wang,Wei Chen,Zhao He,Yong Q Chen
View all publications
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Product promise

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For full details, please see our Terms & Conditions

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