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AB140934

Anti-PACE4 antibody

0

(1 Review)

|

(2 Publications)

Rabbit Polyclonal PACE4 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human PCSK6.

View Alternative Names

PACE4, PCSK6, Proprotein convertase subtilisin/kexin type 6, Paired basic amino acid cleaving enzyme 4, Subtilisin-like proprotein convertase 4, Subtilisin/kexin-like protease PACE4, SPC4

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PACE4 antibody (AB140934)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PACE4 antibody (AB140934)

Immunohistochemical analysis of formalin fixed, paraffin embedded Human brain tissue (cortex) labelling PACE4 with ab140934 at 15 µg/ml.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human PCSK6. The exact immunogen used to generate this antibody is proprietary information.

P29122

Specificity

BLAST analysis of the peptide immunogen showed no homology with other Human proteins.

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Alternative Products

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Secondary Antibodies

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Primary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "10-15 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Common marmoset": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PACE4 also known as PCSK6 is a member of the proprotein convertase family that functions mechanically as a serine endoprotease. This protein plays a role in cleaving precursors of hormones and other proteins to activate their bioactive forms. PACE4 has a molecular mass of approximately 97 kDa. It is expressed in various tissues including the brain pituitary gland and reproductive organs indicative of its involvement in diverse physiological processes.
Biological function summary

PACE4 participates in cellular and developmental processes by processing precursors into active proteins. It is part of a complex of proprotein convertases responsible for the maturation of secretory pathway proteins. PACE4 takes part in the regulation of growth factors matrix metalloproteinases and adhesion molecules exerting influence on cellular growth and development as well as extracellular matrix remodeling.

Pathways

PACE4 involves itself in specific signaling pathways integral to the activation of precursor proteins. It prominently participates in the TGF-beta signaling pathway where it activates transforming growth factor-beta precursors. PACE4 also acts in pathways implicated in the release of active forms of proteins such as integrins and collagens working alongside related convertases such as furin which shares overlapping substrate specificity.

PACE4 contribution links to pathological processes in certain cancers and osteoarthritis through its regulation of tumor growth and cartilage degradation respectively. In cancer PACE4 activates matrix metalloproteinases that aid tumor invasion and metastasis. Its relation with cancer involves interactions with other proteins like MMP-2 enhancing the potential for cellular invasiveness. In osteoarthritis PACE4's influence on cartilage tissue involves connections with ADAMTSs impacting cartilage matrix composition and health.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues.
See full target information PCSK6
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in physiology 12:673497 PubMed34733169

2021

Distribution of Cardiac and Renal Corin and Proprotein Convertase Subtilisin/Kexin-6 in the Experimental Model of Cardio-Renal Syndrome of Various Severities.

Applications

Unspecified application

Species

Unspecified reactive species

Emad E Khoury,Ahmad Fokra,Safa Kinaneh,Yara Knaney,Doron Aronson,Zaid Abassi

Human molecular genetics 25:1140-51 PubMed26744331

2016

Gene network and familial analyses uncover a gene network involving Tbx5/Osr1/Pcsk6 interaction in the second heart field for atrial septation.

Applications

Unspecified application

Species

Unspecified reactive species

Ke K Zhang,Menglan Xiang,Lun Zhou,Jielin Liu,Nathan Curry,Damian Heine Suñer,Pablo Garcia-Pavia,Xiaohua Zhang,Qin Wang,Linglin Xie
View all publications
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Product promise

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