Rabbit Polyclonal PACE4 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human PCSK6.
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- Frontiers in physiology 12:6734972021Distribution of Cardiac and Renal Corin and Proprotein Convertase Subtilisin/Kexin-6 in the Experimental Model of Cardio-Renal Syndrome of Various Severities.Applications:Unspecified applicationReactive species:Unspecified reactive speciesEmad E Khoury,Ahmad Fokra,Safa Kinaneh,Yara Knaney,Doron Aronson,Zaid AbassiPubMed 34733169
- Human molecular genetics 25:1140-512016Gene network and familial analyses uncover a gene network involving Tbx5/Osr1/Pcsk6 interaction in the second heart field for atrial septation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKe K Zhang et. al.PubMed 26744331
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human PCSK6. The exact immunogen used to generate this antibody is proprietary information. Database link P29122
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
| Common marmoset | Predicted |
| Gorilla | Predicted |
| Monkey | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 10.00000-15.00000 µg/mL | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Monkey, Common marmoset, Gorilla | Dilution info - | Notes - |
Associated Products
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Target data
Function
Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues.
Alternative names
PACE4, PCSK6, Proprotein convertase subtilisin/kexin type 6, Paired basic amino acid cleaving enzyme 4, Subtilisin-like proprotein convertase 4, Subtilisin/kexin-like protease PACE4, SPC4
Recommended products
Rabbit Polyclonal PACE4 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human PCSK6.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human PCSK6. The exact immunogen used to generate this antibody is proprietary information. Database link P29122
- Purification technique
- Affinity purification Immunogen
- Specificity
BLAST analysis of the peptide immunogen showed no homology with other Human proteins.
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
PACE4 also known as PCSK6 is a member of the proprotein convertase family that functions mechanically as a serine endoprotease. This protein plays a role in cleaving precursors of hormones and other proteins to activate their bioactive forms. PACE4 has a molecular mass of approximately 97 kDa. It is expressed in various tissues including the brain pituitary gland and reproductive organs indicative of its involvement in diverse physiological processes.
- Biological function summary
PACE4 participates in cellular and developmental processes by processing precursors into active proteins. It is part of a complex of proprotein convertases responsible for the maturation of secretory pathway proteins. PACE4 takes part in the regulation of growth factors matrix metalloproteinases and adhesion molecules exerting influence on cellular growth and development as well as extracellular matrix remodeling.
- Pathways
PACE4 involves itself in specific signaling pathways integral to the activation of precursor proteins. It prominently participates in the TGF-beta signaling pathway where it activates transforming growth factor-beta precursors. PACE4 also acts in pathways implicated in the release of active forms of proteins such as integrins and collagens working alongside related convertases such as furin which shares overlapping substrate specificity.
- Associated diseases and disorders
PACE4 contribution links to pathological processes in certain cancers and osteoarthritis through its regulation of tumor growth and cartilage degradation respectively. In cancer PACE4 activates matrix metalloproteinases that aid tumor invasion and metastasis. Its relation with cancer involves interactions with other proteins like MMP-2 enhancing the potential for cellular invasiveness. In osteoarthritis PACE4's influence on cartilage tissue involves connections with ADAMTSs impacting cartilage matrix composition and health.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PACE4 antibody (ab140934)
Immunohistochemical analysis of formalin fixed, paraffin embedded Human brain tissue (cortex) labelling PACE4 with ab140934 at 15 µg/ml.
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