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AB243703

Anti-PACS1 antibody

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(1 Publication)

Rabbit Polyclonal PACS1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PACS1 aa 400-550.

View Alternative Names

KIAA1175, PACS1, Phosphofurin acidic cluster sorting protein 1, PACS-1

5 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PACS1 antibody (AB243703)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PACS1 antibody (AB243703)

Formalin-fixed, paraffin-embedded human testis tissue stained for PACS1 using ab243703 at 1/200 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PACS1 antibody (AB243703)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PACS1 antibody (AB243703)

Formalin-fixed, paraffin-embedded human lymph node tissue stained for PACS1 using ab243703 at 1/200 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PACS1 antibody (AB243703)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PACS1 antibody (AB243703)

Negative control :

Formalin-fixed, paraffin-embedded human liver tissue stained for PACS1 using ab243703 at 1/200 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PACS1 antibody (AB243703)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PACS1 antibody (AB243703)

Formalin-fixed, paraffin-embedded human cerebral cortex tissue stained for PACS1 using ab243703 at 1/200 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-PACS1 antibody (AB243703)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-PACS1 antibody (AB243703)

PFA-fixed, Triton X-100 permeabilized A431 (human epidermoid carcinoma cell line) cells labeling PACS1 (Green) using ab243703 at 4 μg/mL in ICC/IF analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human PACS1 aa 400-550. The exact immunogen used to generate this antibody is proprietary information.

Q6VY07

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PACS1 also known as PACSONE and PACS-1 is a cytosolic sorting protein that plays a role in maintaining intracellular cargo and membrane trafficking. It has a molecular weight of approximately 110 kDa. Expressed in various tissues including brain kidney and liver PACS1 works as a bridge connecting trans-Golgi network (TGN) to endosome trafficking pathways where it helps in targeting proteins for endocytosis and recycling back to the TGN.
Biological function summary

PACS1 interacts with various adaptor proteins to regulate the localization of critical signaling molecules within the cell. Its function involves linking to clathrin and interacting with other proteins to form stable complexes ensuring the proper sorting of cargo proteins. This sorting is essential for cell signaling and responses. PACS1's ability to interact with kinases and phosphatases helps regulate the phosphorylation state of other proteins impacting diverse cellular pathways.

Pathways

PACS1 is involved in key intracellular trafficking and protein modification pathways. In particular it plays a significant role in the endocytic recycling pathway which is important in recycling membrane receptors. It closely interacts with clathrin and adaptor protein complexes. Additionally PACS1 is related to the apoptosis pathway through its regulatory effects on protein kinase C. By influencing these pathways PACS1 helps maintain cellular homeostasis and modulate cell survival and communication.

PACS1 mutations have been linked to PACS1 Syndrome a neurodevelopmental disorder characterized by delayed development and distinctive facial features. Additionally PACS1 has a role in some cancers likely due to its involvement in cell-cycle progression and apoptosis and it may interact with the p53 tumor suppressor protein in these contexts. Understanding the specific pathways and interactions involving PACS1 could help target therapeutic strategies for these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. Required for normal ER Ca2+ handling in lymphocytes. Together with WDR37, it plays an essential role in lymphocyte development, quiescence and survival. Required for stabilizing peripheral lymphocyte populations (By similarity).
See full target information PACS1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:9250 PubMed40102459

2025

Identification of methionine metabolism related prognostic model and tumor suppressive functions of BHMT in hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Wenli Liu,Kaiheng Hu,Yaqing Fu,Tianmin Zhou,Qingmei Zhong,Wu Wang,Yang Gui,Ping Zhang,Di Yao,Xiaohong Yang,Weifeng Zhu,Zhuoqi Liu,Daya Luo,Yingqun Xiao
View all publications
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