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AB317417

Anti-PACSIN3 antibody [S04-1F1]

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Rabbit Recombinant Monoclonal PACSIN3 antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human Protein kinase C and casein kinase substrate in neurons protein 3.

View Alternative Names

Protein kinase C and casein kinase substrate in neurons protein 3, SH3 domain-containing protein 6511, PACSIN3

1 Images
Western blot - Anti-PACSIN3 Antibody [S04-1F1] (AB317417)
  • WB

Supplier Data

Western blot - Anti-PACSIN3 Antibody [S04-1F1] (AB317417)

All lanes:

Western blot - Anti-PACSIN3 Antibody [S04-1F1] (ab317417) at 1/1000 dilution

Lane 1:

HeLa cell lysate

Lane 2:

A549 cell lysate

Predicted band size: 48 kDa

false

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

S04-1F1

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human Protein kinase C and casein kinase substrate in neurons protein 3.

Q9UKS6

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>" } } }
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Product details

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification
Storage buffer
pH: 7.4 Preservative: 0.01% Sodium azide Constituents: 55.08% Water, 40% Glycerol (glycerin, glycerine), 0.98% Tris glycine, 0.88% Sodium chloride, 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PACSIN3 also known as Protein Kinase C and Casein Kinase Substrate in Neurons Protein 3 plays a role in cellular endocytosis and cytoskeleton organization. This protein is about 47 kDa in size. You find PACSIN3 widely expressed in muscle and heart tissues. It contains an F-BAR domain allowing it to bind membranes and promote membrane curvature. This F-BAR domain is a feature of proteins involved in membrane dynamics.
Biological function summary

The role of PACSIN3 extends into various cellular processes related to membrane trafficking where it acts to modulate vesicular transport and actin reorganization. PACSIN3 interacts with other proteins to form complexes that facilitate the internalization and recycling of receptors on the cell surface. Additionally its interaction with other proteins helps regulate cytoskeletal rearrangements essential for various cellular functions.

Pathways

Functions involving PACSIN3 integrate into key signaling pathways such as the endocytic pathway and the actin polymerization pathway. Within these pathways PACSIN3 interacts with proteins like dynamin a GTPase involved in the scission of budding vesicles from the membrane. Additionally it shares functional connections with proteins such as CTTN (cortactin) another actin-binding protein that influences actin polymerization and cellular movement processes.

Several links exist between PACSIN3 and diseases associated with dysregulated endocytosis and impaired cell signaling including muscular dystrophy and heart failure. PACSIN3's relationship with dynamin which is implicated in these conditions illustrates its potential role in the progression or mitigation of these disorders. Connections between PACSIN3 and other signaling proteins such as Rho GTPases further highlight its possible involvement in these pathological states given their importance in actin cytoskeleton dynamics and membrane trafficking.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity).
See full target information Protein kinase C and casein kinase substrate in neurons protein 3
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Product promise

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For full details, please see our Terms & Conditions

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