AB28207

Anti-PAI1 antibody

Name: Anti-PAI1 antibody (ab28207) | Abcam
Brand: Abcam Limited
SKU: AB28207
Price: 435 USD
Availability: InStock

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(21 Publications)

Rabbit Polyclonal PAI1 antibody. Suitable for WB, IHC-Fr and reacts with Mouse samples. Cited in 21 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Mouse Serpine1.

View Alternative Names

Mr1, Pai1, Planh1, Serpine1, Plasminogen activator inhibitor 1, PAI, PAI-1, Endothelial plasminogen activator inhibitor, Serpin E1

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse

Applications

IHC-Fr, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Mouse Serpine1.

P22777

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Purification notes

This is an IgG purified fraction (purified by Protein A Sepharose).

Storage buffer

pH: 6.6 Constituents: 0.82% Sodium phosphate, 0.58% Sodium chloride, 0.0292% EDTA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair (By similarity). Involved in cellular and replicative senescence (PubMed : 16862142). Plays a role in alveolar type 2 cells senescence in the lung (PubMed : 28722352). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (By similarity).

See full target information Serpine1

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Publications (21)

Recent publications for all applications. Explore the full list and refine your search

Orphanet journal of rare diseases 18:205 PubMed37542348

2023

PAI1 inhibits the pathogenesis of primary focal hyperhidrosis by targeting CHRNA1.

Applications

Unspecified application

Species

Unspecified reactive species

Jian-Feng Chen,Min Lin,Xu Li,Jian-Bo Lin

Frontiers in genetics 14:1175716 PubMed37214419

2023

Assessing the effects of aging on the renal endothelial cell landscape using single-cell RNA sequencing.

Applications

Unspecified application

Species

Unspecified reactive species

Mengke Li,Dongliang Wang,Zhong Liu,Yanjing Huang,Qikai Zhang,Caineng Pan,Yuheng Lin,Li Sun,Yingfeng Zheng

Cellular and molecular life sciences : CMLS 79:323 PubMed35633384

2022

PAI-1 production by reactive astrocytes drives tissue dysfibrinolysis in multiple sclerosis models.

Applications

Unspecified application

Species

Unspecified reactive species

Héloïse Lebas,Sylvaine Guérit,Audrey Picot,Anne Cécile Boulay,Antoine Fournier,Denis Vivien,Martine Cohen Salmon,Fabian Docagne,Isabelle Bardou

EMBO molecular medicine 13:e14146 PubMed34725920

2021

Glomerular endothelial cell senescence drives age-related kidney disease through PAI-1.

Applications

Unspecified application

Species

Unspecified reactive species

Camille Cohen,Océane Le Goff,Frédéric Soysouvanh,Florence Vasseur,Marine Tanou,Clément Nguyen,Lucile Amrouche,Julien Le Guen,Oriana Saltel-Fulero,Tanguy Meunier,Thao Nguyen-Khoa,Marion Rabant,Dominique Nochy,Christophe Legendre,Gérard Friedlander,Bennett G Childs,Daren J Baker,Bertrand Knebelmann,Dany Anglicheau,Fabien Milliat,Fabiola Terzi

Experimental brain research 237:3419-3430 PubMed31734788

2019

Increased expression of plasminogen activator inhibitor-1 (PAI-1) is associated with depression and depressive phenotype in C57Bl/6J mice.

Applications

Unspecified application

Species

Unspecified reactive species

René A Girard,Prashant S Chauhan,Torry A Tucker,Tim Allen,Jaswinder Kaur,Ann Jeffers,Kathleen Koenig,Galina Florova,Andrey A Komissarov,Tatiana A Gaidenko,Mignote B Chamiso,James Fowler,Danna E Morris,Krishna Sarva,Karan P Singh,Steven Idell,Richard D Idell

Experimental and therapeutic medicine 18:3172-3176 PubMed31572558

2019

MicroRNA-663 participates in myocardial fibrosis through interaction with TGF-β1.

Applications

Unspecified application

Species

Unspecified reactive species

Xiangyang Wu,Jie Zhu,Yalin Wei,Xinqiang Guan,Yanchun Zhang,Wensheng Chen,Bingren Gao

Reproductive biology and endocrinology : RB&E 17:33 PubMed30878040

2019

Expression of the plasminogen system in the physiological mouse ovary and in the pathological polycystic ovary syndrome (PCOS) state.

Applications

Unspecified application

Species

Unspecified reactive species

Genia F Burchall,Dodie S Pouniotis,Helena J Teede,Sanjeeva Ranasinha,Kirsty A Walters,Terrence J Piva

Proceedings of the National Academy of Sciences of 115:E1289-E1298 PubMed29358399

2018

Tau induces blood vessel abnormalities and angiogenesis-related gene expression in P301L transgenic mice and human Alzheimer's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Rachel E Bennett,Ashley B Robbins,Miwei Hu,Xinrui Cao,Rebecca A Betensky,Tim Clark,Sudeshna Das,Bradley T Hyman

BMC cancer 17:350 PubMed28526008

2017

Cleavage of the urokinase receptor (uPAR) on oral cancer cells: regulation by transforming growth factor - β1 (TGF-β1) and potential effects on migration and invasion.

Applications

Unspecified application

Species

Unspecified reactive species

Synnove Norvoll Magnussen,Elin Hadler-Olsen,Daniela Elena Costea,Eli Berg,Cristiane Cavalcanti Jacobsen,Bente Mortensen,Tuula Salo,Inigo Martinez-Zubiaurre,Jan-Olof Winberg,Lars Uhlin-Hansen,Gunbjorg Svineng

The Journal of pharmacology and experimental therapeutics 361:140-150 PubMed28174211

2017

Overlapping and Divergent Actions of Structurally Distinct Histone Deacetylase Inhibitors in Cardiac Fibroblasts.

Applications

Unspecified application

Species

Unspecified reactive species

Katherine B Schuetze,Matthew S Stratton,Weston W Blakeslee,Michael F Wempe,Florence F Wagner,Edward B Holson,Yin-Ming Kuo,Andrew J Andrews,Tonya M Gilbert,Jacob M Hooker,Timothy A McKinsey

View all publications

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Product promise

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